{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FBXO17 is an F‐box protein that functions as a substrate receptor within SKP1–Cullin–F‐box (SCF) E3 ubiquitin ligase complexes, mediating the ubiquitination and subsequent proteasomal degradation of key regulatory proteins. Several studies have shown that FBXO17 promotes the polyubiquitination and degradation of glycogen synthase kinase‑3β (GSK3β), thereby modulating downstream signaling pathways—including Akt, ERK, and mTOR—that control cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, FBXO17 has been implicated in the regulation of innate immune responses by interacting with interferon regulatory factor 3 (IRF3) and recruiting protein phosphatase 2 (PP2A) to facilitate IRF3 dephosphorylation, thereby negatively modulating type I interferon signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Elevated expression of FBXO17 appears to be a driver of tumor progression in several cancer types. In hepatocellular carcinoma, overexpression of FBXO17 is associated with increased cell proliferation, enhanced metastasis, and malignant progression through inhibition of GSK3β and activation of the Wnt/β‑catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In renal cell carcinoma, a circular RNA (circ_0008717) promotes tumor progression by targeting miR‑217 to activate FBXO17, further emphasizing its role in oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Studies in high‐grade gliomas have demonstrated that FBXO17 acts as an oncogenic factor by enhancing glycolysis and epithelial–mesenchymal transition through deregulation of the Akt/GSK‑3β/snail signaling axis, thereby promoting cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Conversely, in other tumor types such as breast cancer and esophageal squamous cell carcinoma, the expression levels of FBXO17 have been linked with patient outcomes, suggesting its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings position FBXO17 as a multifaceted regulator of critical signaling pathways in both tumorigenesis and immune responses, highlighting its promise as a target for therapeutic intervention and as a biomarker for disease prognosis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tomeka Suber, Jianxin Wei, Anastasia M Jacko, et al. 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