FBXO31 Gene

HGNC Family	F-boxes (FBX)
Name	F-box protein 31
Description	This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FBXO31 is an F‐box protein that functions as a substrate-recognition subunit of the SCF (Skp1-Cul1-F-box) E3 ubiquitin ligase complex, mediating the ubiquitination and proteasomal degradation of key signaling proteins. In response to genotoxic stress in cancer cells, FBXO31 binds to and targets MKK6 for Lys-48–linked polyubiquitination, thereby attenuating p38 MAPK activation and protecting cells from stress-induced apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, FBXO31 has been implicated in regulating cell cycle and DNA damage responses; its levels increase after DNA damage to promote the degradation of proteins such as cyclin D1 and MDM2, a function that may help maintain genomic stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FBXO31 also regulates other signaling pathways in a context-dependent manner. In human bone marrow–derived mesenchymal stem cells, FBXO31 interacts with the deubiquitinating enzyme USP53 to promote proteasomal degradation of β-catenin, thereby inhibiting osteogenic differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, FBXO31 is overexpressed and exerts antiapoptotic effects by deactivating stress-induced MAPK p38α and JNK, contributing to tumor progression and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, microRNAs play a significant role in modulating FBXO31 expression. In esophageal squamous cell carcinoma, miR-210 downregulates FBXO31 to regulate epithelial-mesenchymal transition and Wnt/β-catenin signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", whereas an inverse expression relationship between miR-210 and FBXO31 is also observed in breast cancer, where FBXO31 appears to mediate tumor-suppressive effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In other disease contexts, altered FBXO31 expression has been associated with pathological conditions. For example, in a mouse model of lean non-alcoholic steatohepatitis, suppressed mRNA expression of FBXO31 was linked to dysregulation of cyclin D1 activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Additionally, a submicroscopic chromosomal deletion encompassing FBXO31 has been identified in a patient with congenital anomalies including distichiasis and microcephaly, suggesting that loss of FBXO31 may contribute to developmental defects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight the multifaceted, context-dependent roles of FBXO31 in regulating critical signaling pathways involved in stress response, cell cycle control, differentiation, and tumorigenesis. Its functions as both a negative regulator of mitogenic and stress signals and, in certain cancers, as a factor promoting cell survival underscore its potential as a therapeutic target in diverse pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jia Liu, Liang Han, Bin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.560342"}], "href": "https://doi.org/10.1074/jbc.M114.560342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24936062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24936062"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Srinadh Choppara, Sankaran Ganga, Rajeshkumar Manne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SCF"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "FBXO46"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.005354"}], "href": "https://doi.org/10.1074/jbc.RA118.005354"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30171069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30171069"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Parul Dutta, Sehbanul Islam, Srinadh Choppara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.007055"}], "href": "https://doi.org/10.1074/jbc.RA118.007055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31413110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31413110"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuyong Tan, Deliang Liu, Jian Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of F-box only protein 31 in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2018.7816"}], "href": "https://doi.org/10.3892/ol.2018.7816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29556284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29556284"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03517-x"}], "href": "https://doi.org/10.1038/s41419-021-03517-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33664230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33664230"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jia Liu, Liang Lv, Jian Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of F-box only protein 31 predicts poor prognosis and deregulates p38α- and JNK-mediated apoptosis in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31040"}], "href": "https://doi.org/10.1002/ijc.31040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28905993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28905993"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jing Meng, Chao Zhang, Tongquan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-210 targets FBXO31 to inhibit tumor progression and regulates the Wnt/β-catenin signaling pathway and EMT in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.13860"}], "href": "https://doi.org/10.1111/1759-7714.13860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33538099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33538099"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Dayue Liu, Haoming Xia, Fang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-210 interacts with FBXO31 to regulate cancer proliferation cell cycle and migration in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S110969"}], "href": "https://doi.org/10.2147/OTT.S110969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27601917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27601917"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Atsuko Nakatsuka, Makoto Matsuyama, Satoshi Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21721"}], "href": "https://doi.org/10.1038/srep21721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26883167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26883167"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Matthew G Butler, Susan L Dagenais, José L Garcia-Perez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.35229"}], "href": "https://doi.org/10.1002/ajmg.a.35229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22407726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22407726"}]}]}]}
Synonyms	FBX31, PP2386, FBX14, FBXO14, MRT45
Proteins	FBX31_HUMAN
NCBI Gene ID	79791
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FBXO31 has 5,946 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for FBXO31 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FBXO31 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXO31 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXO31 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FBXO31 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FBXO31 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FBXO31 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXO31 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FBXO31 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FBXO31 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBXO31 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FBXO31 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FBXO31 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXO31 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FBXO31 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FBXO31 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FBXO31 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FBXO31 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FBXO31 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FBXO31 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FBXO31 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FBXO31 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FBXO31 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FBXO31 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBXO31 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FBXO31 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FBXO31 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FBXO31 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FBXO31 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FBXO31 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FBXO31 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FBXO31 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FBXO31 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FBXO31 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FBXO31 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXO31 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FBXO31 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FBXO31 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FBXO31 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FBXO31 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FBXO31 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FBXO31 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.