FBXW5 Gene

HGNC Family	F-boxes (FBX), WD repeat domain containing (WDR)
Name	F-box and WD repeat domain containing 5
Description	This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FBXW5 is emerging as a multifunctional F‐box protein that coordinates diverse cellular processes by targeting key regulatory proteins for ubiquitin‐dependent modification. In several studies, FBXW5 has been shown to control cell cycle progression and centrosome homeostasis by promoting the ubiquitination and degradation of substrates such as the centriolar protein HsSAS‐6, thereby restricting centrosome duplication (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, FBXW5 targets components of membrane transport and autophagy regulation; for example, it directs the proteasomal degradation of SEC23B—a core COPII complex component—to limit autophagosome biogenesis under nutrient‐rich conditions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", and it facilitates TSC2 turnover within the TSC complex, a process that is counteracted by protective partners such as TSC1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of disease, FBXW5 acts as an important modulator of signaling cascades. Its participation in the degradation of DLC1 in non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and of LATS1 in gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "links FBXW5 activity to the regulation of oncogenic pathways such as Hippo signaling and underscores its role in tumor proliferation, invasion, metastasis, and chemoresistance. Furthermore, FBXW5 also contributes to the regulation of inflammatory and stress responses; it facilitates ubiquitination of ASK1, thereby controlling IL-1β-induced kinase activation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and its binding to proteins involved in autophagic regulation in dopaminergic neurons appears to stabilize TSC2 and enhance autophagy under oxidative stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FBXW5’s role is not limited to these intracellular events. Its differential expression has been associated with stress responses across species, as evidenced by its identification among candidate genes linked to heat stress in catfish"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "and with improved outcomes following knockdown in spinal cord injury models, where reduced FBXW5 levels correlated with decreased activation of inflammatory kinases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In human skeletal muscle, elevated FBXW5 expression correlates positively with markers of insulin sensitivity and the activation of autophagy-related pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while network analyses in muscular dystrophy also nominate FBXW5 as a hub in regulatory circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, FBXW5 contributes to post-translational modification of transcription factors; it enhances the sumoylation of nuclear c-Myb via a DDB1–CUL4A–Rbx1 complex"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", adding an extra layer of control over gene expression. Finally, in liver ischemia/reperfusion injury, upregulation of FBXW5 has been implicated in amplifying inflammatory responses through the phosphorylation of ASK1 in a TRAF6-dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore that FBXW5 functions as a critical substrate receptor within distinct E3 ubiquitin ligase complexes to orchestrate protein turnover. Through its precise modulation of proteins involved in centrosome duplication, autophagosome formation, oncogenic signaling, stress response, and metabolic regulation, FBXW5 emerges as an attractive therapeutic target in cancer, neurodegeneration, and metabolic as well as inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_fs", "start_ref": "6", "end_ref": "10"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anja Puklowski, Yahya Homsi, Debora Keller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2282"}], "href": "https://doi.org/10.1038/ncb2282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21725316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21725316"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yeon-Tae Jeong, Daniele Simoneschi, Sarah Keegan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ULK1-FBXW5-SEC23B nexus controls autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.42253"}], "href": "https://doi.org/10.7554/eLife.42253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30596474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30596474"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jian Hu, Sima Zacharek, Yizhou Joseph He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1624008"}], "href": "https://doi.org/10.1101/gad.1624008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18381890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18381890"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tai Young Kim, Sarah Jackson, Yue Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1306358110"}], "href": "https://doi.org/10.1073/pnas.1306358110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24082123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24082123"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yangyang Yao, Zhen Liu, Shanshan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-022-00868-y"}], "href": "https://doi.org/10.1038/s41420-022-00868-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35210431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35210431"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lan Bai, Ming-Ming Chen, Ze-Dong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30537"}], "href": "https://doi.org/10.1002/hep.30537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30703849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30703849"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ji-Young Ha, Ji-Soo Kim, Young-Hee Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.12643"}], "href": "https://doi.org/10.1111/jnc.12643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24444419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24444419"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Jin, T Zhou, X Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of heat stress-associated SNPs in catfish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anim Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/age.12482"}], "href": "https://doi.org/10.1111/age.12482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27476875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27476875"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Pengfei Zhao, Wang Chao, Weiguo Li "}, {"type": "b", "children": [{"type": "t", "text": "FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.086"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31060780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31060780"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hemang M Parikh, Targ Elgzyri, Amra Alibegovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between insulin sensitivity and gene expression in human skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Endocr Disord (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12902-021-00687-9"}], "href": "https://doi.org/10.1186/s12902-021-00687-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33639916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33639916"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Meng-Xi Xiu, Bin Zeng, Bo-Hai Kuang "}, {"type": "b", "children": [{"type": "t", "text": "Identification of hub genes, miRNAs and regulatory factors relevant for Duchenne muscular dystrophy by bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Neurosci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00207454.2020.1810030"}], "href": "https://doi.org/10.1080/00207454.2020.1810030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32791870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32791870"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Chie Kanei-Ishii, Teruaki Nomura, Ayako Egoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2012.08.032"}], "href": "https://doi.org/10.1016/j.bbrc.2012.08.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22910413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22910413"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ting-Ting Li, Yun-Hai Luo, Hang Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FBXW5 aggravates hepatic ischemia/reperfusion injury via promoting phosphorylation of ASK1 in a TRAF6-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2021.107928"}], "href": "https://doi.org/10.1016/j.intimp.2021.107928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34217994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34217994"}]}]}]}
Synonyms	FBW5
Proteins	FBXW5_HUMAN
NCBI Gene ID	54461
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FBXW5 has 5,415 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 106 datasets.

Click the + buttons to view associations for FBXW5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FBXW5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXW5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXW5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FBXW5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FBXW5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FBXW5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FBXW5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FBXW5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FBXW5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBXW5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FBXW5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FBXW5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXW5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FBXW5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FBXW5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing FBXW5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FBXW5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FBXW5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FBXW5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FBXW5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FBXW5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FBXW5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FBXW5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FBXW5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FBXW5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FBXW5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FBXW5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FBXW5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FBXW5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FBXW5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FBXW5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FBXW5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FBXW5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FBXW5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FBXW5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FBXW5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FBXW5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FBXW5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of FBXW5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of FBXW5 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FBXW5 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.