FGA Gene

HGNC Family	Fibrinogen C domain containing, Endogenous ligands
Name	fibrinogen alpha chain
Description	This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nFibrinogen alpha (FGA) encodes the Aα‐chain, a critical constituent of the fibrinogen hexamer that underpins blood clot formation. The Aα‐chain features distinct domains—including the N‐terminal regions, the coiled‐coil segments, and prominently the C‐terminal αC‐domain—that govern lateral aggregation and factor XIII–mediated cross‐linking to stabilize the fibrin network. Mutations affecting FGA—including splice‐site disruptions and amino acid substitutions such as Thr312Ala—disrupt proper synthesis, assembly, and structural integrity, thereby leading to quantitative and qualitative fibrinogen deficiencies evident in conditions such as afibrinogenemia and dysfibrinogenemia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its essential hemostatic role, the structural elements encoded by FGA mediate critical interactions with cellular and microbial ligands. The C‐terminal region of the Aα‐chain, for example, provides a binding site for bacterial adhesins—as demonstrated by its interaction with Staphylococcus aureus clumping factor B—which can facilitate pathogen adherence and may influence local clot remodeling during infection."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAltered FGA expression and function have also been implicated in diverse pathological processes. In oncological contexts, loss of FGA in lung adenocarcinoma models enhances cell proliferation, migration, and invasion through integrin‐mediated modulation of the AKT–mTOR signaling pathway, whereas elevated salivary levels of the Aα‐chain correlate with advanced oral squamous cell carcinoma, underscoring its potential as a biomarker. Furthermore, exome‐wide screening in recurrent pregnancy loss has identified FGA mutations that induce significant energetic and functional changes, linking FGA disruption to adverse reproductive outcomes. Together, these findings illustrate the multifaceted role of FGA in maintaining hemostatic balance and its emerging significance as a diagnostic and therapeutic target in both vascular and neoplastic diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Catia Attanasio, Armelle David, Marguerite Neerman-Arbez "}, {"type": "b", "children": [{"type": "t", "text": "Outcome of donor splice site mutations accounting for congenital afibrinogenemia reflects order of intron removal in the fibrinogen alpha gene (FGA)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-03-0853"}], "href": "https://doi.org/10.1182/blood-2002-03-0853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12406899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12406899"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kristina F Standeven, Peter J Grant, Angela M Carter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000066690.89407.CE"}], "href": "https://doi.org/10.1161/01.CIR.0000066690.89407.CE"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12707238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12707238"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rustem I Litvinov, Sergiy Yakovlev, Galina Tsurupa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct evidence for specific interactions of the fibrinogen alphaC-domains with the central E region and with each other."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi700944j"}], "href": "https://doi.org/10.1021/bi700944j"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17630702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17630702"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Galina Tsurupa, Igor Pechik, Rustem I Litvinov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "On the mechanism of αC polymer formation in fibrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi2017848"}], "href": "https://doi.org/10.1021/bi2017848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22397628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22397628"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Evelyn J Walsh, Helen Miajlovic, Oleg V Gorkun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbiology (Reading) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1099/mic.0.2007/010868-0"}], "href": "https://doi.org/10.1099/mic.0.2007/010868-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18227259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18227259"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paula Quintero-Ronderos, Eric Mercier, Michiko Fukuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel genes and mutations in patients affected by recurrent pregnancy loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0186149"}], "href": "https://doi.org/10.1371/journal.pone.0186149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29016666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29016666"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hao-Wei Chu, Kai-Ping Chang, Chia-Wei Hsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Salivary Biomarkers for Oral Cancer Detection with Untargeted and Targeted Quantitative Proteomics Approaches."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.RA119.001530"}], "href": "https://doi.org/10.1074/mcp.RA119.001530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31253657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31253657"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Meng Wang, Guangxin Zhang, Yue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibrinogen Alpha Chain Knockout Promotes Tumor Growth and Metastasis through Integrin-AKT Signaling Pathway in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-19-1033"}], "href": "https://doi.org/10.1158/1541-7786.MCR-19-1033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32205365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32205365"}]}]}]}
Synonyms	Fib2
Proteins	FIBA_HUMAN
NCBI Gene ID	2243
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FGA has 7,978 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 133 datasets.

Click the + buttons to view associations for FGA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FGA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FGA gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FGA gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FGA gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FGA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Biocarta Pathways	pathways involving FGA protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FGA gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FGA gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FGA gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FGA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FGA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FGA gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FGA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FGA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FGA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FGA gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FGA gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FGA gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FGA gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FGA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FGA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FGA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FGA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FGA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FGA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FGA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FGA gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FGA gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FGA protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FGA gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for FGA protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving FGA gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FGA gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FGA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FGA gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FGA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FGA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FGA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FGA gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FGA protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FGA gene from the ENCODE Histone Modification Site Profiles dataset.