{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FIGLA, a germ cell–specific basic helix–loop–helix transcription factor, is a central regulator of early oogenesis and folliculogenesis. By activating transcription of oocyte‐restricted genes—including those encoding the zona pellucida proteins (ZP1, ZP2, and ZP3) essential for oocyte structure—and by repressing genes normally expressed in male germ cells, FIGLA orchestrates the formation of primordial follicles and promotes oocyte survival. Its function is integrated within a broader network of oocyte‐specific transcription factors (such as NOBOX, LHX8, SOHLH1, and SOHLH2) that coordinate gene expression programs necessary for the proper differentiation of oocytes and for the maintenance of the ovarian reserve. Moreover, studies in both mouse and human indicate that disruption of FIGLA function—whether by mutation affecting its ability to dimerize and bind target promoters or by loss of expression—leads to impaired folliculogenesis and is associated with premature ovarian failure/insufficiency. Collectively, these findings underscore the dual role of FIGLA in activating oocyte‐specific developmental programs while simultaneously repressing inappropriate gene expression, thereby ensuring the establishment and maintenance of female fertility."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stephanie A Pangas, Youngsok Choi, Daniel J Ballow, et al. 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