FIGNL1 Gene

HGNC Family	ATPases
Name	fidgetin-like 1
Description	This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FIGNL1 is a multifunctional AAA‐ATPase that plays key roles in maintaining genomic integrity, regulating DNA repair, and modulating diverse cellular processes. In human cells, FIGNL1 interacts directly with the RAD51 recombinase through its conserved RAD51‐binding domain and, together with its partner SPIDR, participates in homologous recombination (HR) repair. Studies have shown that FIGNL1 can promote the dissociation of RAD51 from single‑stranded DNA, thereby acting as an “anti‐recombinase” to fine‑tune RAD51 filament dynamics and prevent aberrant HR events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In Arabidopsis, FIDGETIN‑LIKE‑1 similarly limits the formation of RAD51/DMC1 nucleoprotein filaments, acting in opposition to positive mediators like BRCA2 and highlighting an evolutionarily conserved function in recombination regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in DNA repair, genetic studies in mice have implicated Fignl1 in male meiosis; non‑synonymous coding variations in Fignl1 are associated with altered spermatocyte kinetics and reduced testis size, suggesting that FIGNL1 is critical for proper meiotic progression during spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the context of bone biology, FIGNL1 appears to modulate osteoblast behavior; overexpression of FIGNL1 in osteoblastic cells inhibits proliferation while promoting differentiation, indicating that it may serve as a regulatory checkpoint during osteoblastogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant FIGNL1 expression is also linked to cancer. In small cell lung cancer, elevated levels of FIGNL1 correlate with enhanced DNA double‑strand break repair capacity and contribute to chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", while in other studies, increased FIGNL1 was associated with tumorigenesis and cell cycle deregulation in lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, FIGNL1 has been implicated in neural development. In zebrafish, for example, FIGNL1 forms a complex with motor proteins and acts as a critical regulator of bidirectional axonal transport, thereby influencing motor axon pathfinding through modulation of dynein activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Structural and biochemical studies in Caenorhabditis elegans have further revealed that the AAA domain of FIGL1 exhibits unusually high ATPase activity driven by unique intersubunit charge interactions that promote hexamer formation. This structural feature is essential for its function in regulating mitotic progression in the germ line and early embryogenesis, as loss of FIGL1 disrupts normal cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, proteomic analyses have identified FIGNL1 as a DNA repair protein whose expression is altered in aging ovarian follicles, suggesting a potential role in the maintenance of genome integrity during ovarian aging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies establish FIGNL1 as a critical regulator of homologous recombination, cell cycle progression, and intracellular transport, with broad implications for development, tissue homeostasis, and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jingsong Yuan, Junjie Chen "}, {"type": "b", "children": [{"type": "t", "text": "FIGNL1-containing protein complex is required for efficient homologous recombination repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1220662110"}], "href": "https://doi.org/10.1073/pnas.1220662110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23754376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23754376"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kenichiro Matsuzaki, Shizuka Kondo, Tatsuya Ishikawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-019-09190-1"}], "href": "https://doi.org/10.1038/s41467-019-09190-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30926776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30926776"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rajeev Kumar, Marine Duhamel, Eve Coutant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antagonism between BRCA2 and FIGL1 regulates homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkz225"}], "href": "https://doi.org/10.1093/nar/gkz225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30941419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30941419"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David L'Hôte, Magalie Vatin, Jana Auer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0027582"}], "href": "https://doi.org/10.1371/journal.pone.0027582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22110678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22110678"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Su Jin Park, Su Jin Kim, Yumie Rhee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fidgetin-like 1 gene inhibited by basic fibroblast growth factor regulates the proliferation and differentiation of osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.070311"}], "href": "https://doi.org/10.1359/jbmr.070311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17352653"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17352653"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jian Ma, Jianlei Li, Xiaoling Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5483"}], "href": "https://doi.org/10.3892/or.2017.5483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28260065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28260065"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Miao Li, Yan Rui, Wenjia Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIGNL1 promotes non‑small cell lung cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2020.5154"}], "href": "https://doi.org/10.3892/ijo.2020.5154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33367932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33367932"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zicheng Zhen, Minghao Li, Muyan Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIGNL1 Expression and its Prognostic Significance in Pan-cancer Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comb Chem High Throughput Screen (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1386207325666220301110517"}], "href": "https://doi.org/10.2174/1386207325666220301110517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35232348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35232348"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Melody Atkins, Laïla Gasmi, Valérie Bercier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201805128"}], "href": "https://doi.org/10.1083/jcb.201805128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31541015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31541015"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wentao Peng, Zhijie Lin, Weirong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.502559"}], "href": "https://doi.org/10.1074/jbc.M113.502559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23979136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23979136"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sarah Luke-Glaser, Lionel Pintard, Mike Tyers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.015883"}], "href": "https://doi.org/10.1242/jcs.015883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17878235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17878235"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Vijayakumar Govindaraj, A Jagannadha Rao "}, {"type": "b", "children": [{"type": "t", "text": "Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Syst Biol Reprod Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/19396368.2015.1077903"}], "href": "https://doi.org/10.3109/19396368.2015.1077903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26391928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26391928"}]}]}]}
Proteins	FIGL1_HUMAN
NCBI Gene ID	63979
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FIGNL1 has 5,103 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for FIGNL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FIGNL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FIGNL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FIGNL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FIGNL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FIGNL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FIGNL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FIGNL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FIGNL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FIGNL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FIGNL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FIGNL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FIGNL1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FIGNL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FIGNL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FIGNL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FIGNL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FIGNL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FIGNL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FIGNL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FIGNL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FIGNL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FIGNL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FIGNL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FIGNL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FIGNL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FIGNL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FIGNL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FIGNL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FIGNL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FIGNL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FIGNL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FIGNL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FIGNL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FIGNL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FIGNL1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FIGNL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FIGNL1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FIGNL1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of FIGNL1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of FIGNL1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FIGNL1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.