FKBP1B Gene

HGNC Family	Peptidylprolyl isomerases
Name	FK506 binding protein 1B, 12.6 kDa
Description	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FKBP1B—also known as FKBP12.6 or calstabin2—is an intracellular immunophilin that plays a critical regulatory role in controlling Ca<sup>2+</sup> release from the sarcoplasmic reticulum. In cardiac myocytes, FKBP1B binds to the ryanodine receptor type 2 (RyR2), stabilizing its closed state and thereby preventing aberrant, diastolic Ca<sup>2+</sup> leak that can trigger arrhythmias and sudden cardiac death."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Disruption of FKBP1B binding—whether via mutation-induced conformational changes, hyperphosphorylation of RyR2, or other post-translational modifications—leads to “leaky” Ca<sup>2+</sup> channels that have been implicated in conditions such as catecholaminergic polymorphic ventricular tachycardia (CPVT) and familial polymorphic ventricular tachycardia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Therapeutic agents (for example, S107 and JTV519) that enhance the RyR2–FKBP1B interaction help restore proper channel function and prevent the diastolic Ca<sup>2+</sup> leak, thereby reducing the propensity for arrhythmia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, detailed biophysical studies have demonstrated that FKBP1B’s binding affinity for RyR2 is high and that its presence is essential for maintaining normal Ca<sup>2+</sup>‐spark kinetics and channel gating; indeed, disruptions in FKBP1B association (whether by altered phosphorylation states or mutations) result in increased spontaneous Ca<sup>2+</sup> release events that underlie many of the observed electrical instabilities in the heart."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": " Beyond the heart, FKBP1B also contributes to Ca<sup>2+</sup> handling in skeletal and smooth muscle as well as in neuronal tissues, where its regulation of ryanodine receptor function influences excitation–contraction coupling, cellular metabolism, and even processes linked to cognitive function and stress responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Collectively, these studies support a model in which FKBP1B is a key stabilizer of RyR channels across excitable tissues, and its proper function is essential for maintaining Ca<sup>2+</sup> homeostasis; loss or functional alteration of FKBP1B can therefore contribute to a broad spectrum of pathologies, including arrhythmias, heart failure, and neurocognitive deficits.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xander H T Wehrens, Stephan E Lehnart, Fannie Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00434-3"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00434-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12837242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12837242"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Stephan E Lehnart, Marco Mongillo, Andrew Bellinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI35346"}], "href": "https://doi.org/10.1172/JCI35346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18483626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18483626"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "John A Vest, Xander H T Wehrens, Steven R Reiken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective cardiac ryanodine receptor regulation during atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000162461.67140.4C"}], "href": "https://doi.org/10.1161/01.CIR.0000162461.67140.4C"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15851612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15851612"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stephan E Lehnart, Xander H T Wehrens, Päivi J Laitinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circulation (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.CIR.0000132472.98675.EC"}], "href": "https://doi.org/10.1161/01.CIR.0000132472.98675.EC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15197150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15197150"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nian Liu, Barbara Colombi, Mirella Memmi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000235869.50747.e1"}], "href": "https://doi.org/10.1161/01.RES.0000235869.50747.e1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16825580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16825580"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hong-Bo Xin, Takaaki Senbonmatsu, Dong-Sheng Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/416334a"}], "href": "https://doi.org/10.1038/416334a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11907581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11907581"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Christopher H George, Gemma V Higgs, F Anthony Lai "}, {"type": "b", "children": [{"type": "t", "text": "Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000091335.07574.86"}], "href": "https://doi.org/10.1161/01.RES.0000091335.07574.86"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12919952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12919952"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jérémy Fauconnier, Jérôme Thireau, Steven Reiken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0908540107"}], "href": "https://doi.org/10.1073/pnas.0908540107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20080623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20080623"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jian Shan, Matthew J Betzenhauser, Alexander Kushnir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI37649"}], "href": "https://doi.org/10.1172/JCI37649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21099115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21099115"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bailong Xiao, Cindy Sutherland, Michael P Walsh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase A phosphorylation at serine-2808 of the cardiac Ca2+-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.RES.0000115945.89741.22"}], "href": "https://doi.org/10.1161/01.RES.0000115945.89741.22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14715536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14715536"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tao Guo, Razvan L Cornea, Sabine Huke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.110.219816"}], "href": "https://doi.org/10.1161/CIRCRESAHA.110.219816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20431056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20431056"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Subeena Sood, Mihail G Chelu, Ralph J van Oort, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Heart Rhythm (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.hrthm.2008.03.030"}], "href": "https://doi.org/10.1016/j.hrthm.2008.03.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18598963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18598963"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Guillermo Avila, Eun Hui Lee, Claudio F Perez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M205866200"}], "href": "https://doi.org/10.1074/jbc.M205866200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12704193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12704193"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xander H T Wehrens, Stephan E Lehnart, Steven Reiken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0500353102"}], "href": "https://doi.org/10.1073/pnas.0500353102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15972811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15972811"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiaoping Liu, Matthew J Betzenhauser, Steve Reiken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2012.06.052"}], "href": "https://doi.org/10.1016/j.cell.2012.06.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22939628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22939628"}]}]}]}
Synonyms	OTK4, FKBP1L, PKBP1L, FKBP12.6
Proteins	FKB1B_HUMAN
NCBI Gene ID	2281
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FKBP1B has 6,843 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for FKBP1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FKBP1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FKBP1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FKBP1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FKBP1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FKBP1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FKBP1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FKBP1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FKBP1B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FKBP1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FKBP1B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FKBP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FKBP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FKBP1B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FKBP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FKBP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FKBP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FKBP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FKBP1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FKBP1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FKBP1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FKBP1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FKBP1B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FKBP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FKBP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FKBP1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FKBP1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FKBP1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FKBP1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FKBP1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FKBP1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FKBP1B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FKBP1B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FKBP1B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FKBP1B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FKBP1B from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FKBP1B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of FKBP1B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of FKBP1B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.