| Name | uncharacterized LOC401081 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although emerging studies have identified multiple long non‐coding RNAs as key regulators in gastric cancer, recent work has highlighted a novel tumor‐suppressive role for FLJ22763. FLJ22763 is significantly downregulated in gastric cancer tissues, and its reduced expression is associated with adverse clinicopathological features such as a lower histological grade and increased depth of tumor invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional analyses reveal that ectopic expression of FLJ22763 markedly suppresses the malignant behaviors of gastric cancer cells in vitro and significantly inhibits xenograft tumor growth in vivo. These findings suggest that FLJ22763 exerts its tumor‐suppressive effects, at least in part, by negatively regulating the expression of ACLY at both the mRNA and protein levels, thereby implicating ACLY as a potential downstream target in its mechanism of action. In this context, FLJ22763 not only serves as an important prognostic biomarker but may also represent a promising therapeutic target in gastric cancer. Although other lncRNAs, such as TUBA4B, have been similarly implicated in the suppression of gastric cancer progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", the specific modulation of ACLY by FLJ22763 underscores its unique contribution to the molecular network that governs gastric tumorigenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Zhang, Qiaoyan Wang, Jiafei Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA FLJ22763 is involved in the progression and prognosis of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.01.028"}], "href": "https://doi.org/10.1016/j.gene.2019.01.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30716442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30716442"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianbo Guo, Yan Li, He Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA TUBA4B functions as a competitive endogenous RNA to inhibit gastric cancer progression by elevating PTEN via sponging miR-214 and miR-216a/b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0879-x"}], "href": "https://doi.org/10.1186/s12935-019-0879-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31198405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31198405"}]}]}]}
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| Synonyms | C3orf85 |
| NCBI Gene ID | 401081 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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FLJ22763 has 341 functional associations with biological entities spanning 5 categories (molecular profile, organism, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 20 datasets.
Click the + buttons to view associations for FLJ22763 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of FLJ22763 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of FLJ22763 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of FLJ22763 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of FLJ22763 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with FLJ22763 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with FLJ22763 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at FLJ22763 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of FLJ22763 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of FLJ22763 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of FLJ22763 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of FLJ22763 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of FLJ22763 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of FLJ22763 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with FLJ22763 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with FLJ22763 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of FLJ22763 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of FLJ22763 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of FLJ22763 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of FLJ22763 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of FLJ22763 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
