FLRT2 Gene

HGNC Family	Fibronectin type III domain containing
Name	fibronectin leucine rich transmembrane protein 2
Description	This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FLRT2, one of the members of the fibronectin leucine‐rich transmembrane protein family, acts as a versatile regulator of cell adhesion, migration, and signaling in both developmental and disease contexts. During embryogenesis, FLRT2 is expressed in specific mesenchymal and sclerotomal domains where it modulates fibroblast growth factor (FGF) signaling and mediates cell–matrix interactions that are critical for proper somite formation, craniofacial morphogenesis, and epicardial development; indeed, loss of FLRT2 disrupts epicardial sheet integrity and leads to mid‐gestation cardiac insufficiency."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In the placenta, FLRT2 is unexpectedly expressed in endothelial cells of the labyrinth, where its interaction with Unc5 receptors governs interendothelial repulsion, ensuring proper vascular alignment and effective feto–maternal circulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In bone, FLRT2 contributes to the regulation of osteoclast multinucleation by interfering with Netrin1–Unc5b binding, thereby impacting bone remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In several cancers, FLRT2 is frequently subject to epigenetic silencing through promoter hypermethylation. Reduced FLRT2 expression has been reported in non‐small cell lung, breast, colorectal, liver, and renal cancers, and its downregulation is associated with enhanced cell proliferation, migration, and diminished adhesion—findings that support a potential tumor‐suppressor role."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n FLRT2 also plays important roles in cell–matrix interactions. In chondrogenic progenitors, for example, FLRT2 localizes to both the cell membrane and the surrounding extracellular matrix (ECM) where it co‐associates with fibronectin—suggesting a role in regulating cell–ECM adhesion during early chondrogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In addition, changes in FLRT2 expression have been linked to alterations in skeletal muscle FGF responsiveness and have even been proposed as a potential biomarker in conditions such as obstructive sleep apnea."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, FLRT2 has been identified as a novel autoantigen in systemic lupus erythematosus, with autoantibodies against FLRT2 triggering complement‐dependent cytotoxicity toward endothelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, these studies highlight the multifaceted roles of FLRT2—from orchestrating cell–cell repulsion and adhesion in vascular, cardiac, and skeletal development to serving as a tumor suppressor and biomarker in various cancers—and underscore its importance in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bryan P Haines, Lee M Wheldon, Dennis Summerbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2006.04.004"}], "href": "https://doi.org/10.1016/j.ydbio.2006.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16872596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16872596"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pari-Sima Müller, Ramona Schulz, Silvia Maretto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.059386"}], "href": "https://doi.org/10.1242/dev.059386"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21350012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21350012"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "S-G Gong, S Mai, K Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2009.07.009"}], "href": "https://doi.org/10.1016/j.gep.2009.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19635589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19635589"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ikue Tai-Nagara, Yusuke Yoshikawa, Naoko Numata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.149757"}], "href": "https://doi.org/10.1242/dev.149757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28576770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28576770"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jumpei Shirakawa, Noriko Takegahara, Hyunsoo Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flrt2 is involved in fine-tuning of osteoclast multinucleation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMB Rep (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31383250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31383250"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Masashi Kusakabe, Tomoko Kutomi, Kousuke Watanabe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24947"}], "href": "https://doi.org/10.1002/ijc.24947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19816938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19816938"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hansol Bae, Byungtak Kim, Hyunkyung Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-00424-0"}], "href": "https://doi.org/10.1038/s41598-017-00424-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28325946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28325946"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks "}, {"type": "b", "children": [{"type": "t", "text": "Mapping the Germline and Somatic Mutation Interaction Landscape in Indolent and Aggressive Prostate Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/4168784"}], "href": "https://doi.org/10.1155/2019/4168784"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31814827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31814827"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Raimonda Kubiliūtė, Kristina Žukauskaitė, Algirdas Žalimas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of novel DNA methylation biomarkers for renal clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-021-03837-7"}], "href": "https://doi.org/10.1007/s00432-021-03837-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34689221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34689221"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xiaohong Guo, Chao Song, Lei Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FLRT2 functions as Tumor Suppressor gene inactivated by promoter methylation in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/jca.47558"}], "href": "https://doi.org/10.7150/jca.47558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33193897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33193897"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Y Xu, K Wei, W Kulyk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FLRT2 promotes cellular proliferation and inhibits cell adhesion during chondrogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.23271"}], "href": "https://doi.org/10.1002/jcb.23271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21769912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21769912"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "K A Flintoff, Y Arudchelvan, Siew-Ging Gong "}, {"type": "b", "children": [{"type": "t", "text": "FLRT2 interacts with fibronectin in the ATDC5 chondroprogenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24597"}], "href": "https://doi.org/10.1002/jcp.24597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24585683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24585683"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shih-Wei Lin, Chi-Neu Tsai, Yun-Shien Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/2319-4170.113188"}], "href": "https://doi.org/10.4103/2319-4170.113188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24732660"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24732660"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wei-Hua Jia, Nuo-Qi Wang, Lin Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Sex Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13293-020-00287-7"}], "href": "https://doi.org/10.1186/s13293-020-00287-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32156311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32156311"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar3897"}], "href": "https://doi.org/10.1186/ar3897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22747982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22747982"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Verity A Jackson, Shahid Mehmood, Matthieu Chavent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Super-complexes of adhesion GPCRs and neural guidance receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11184"}], "href": "https://doi.org/10.1038/ncomms11184"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27091502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27091502"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yu Wu, Jerry Davison, Xiaoyu Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15592294.2016.1148867"}], "href": "https://doi.org/10.1080/15592294.2016.1148867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26890304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26890304"}]}]}]}
Proteins	FLRT2_HUMAN
NCBI Gene ID	23768
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FLRT2 has 7,227 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for FLRT2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FLRT2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FLRT2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FLRT2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FLRT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FLRT2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FLRT2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FLRT2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FLRT2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FLRT2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FLRT2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FLRT2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FLRT2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FLRT2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FLRT2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FLRT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FLRT2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FLRT2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FLRT2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FLRT2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FLRT2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FLRT2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FLRT2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FLRT2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FLRT2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FLRT2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FLRT2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FLRT2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FLRT2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FLRT2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FLRT2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FLRT2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FLRT2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FLRT2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FLRT2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FLRT2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FLRT2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FLRT2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FLRT2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FLRT2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FLRT2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FLRT2 from the GeneSigDB Published Gene Signatures dataset.