FLT3 Gene

HGNC Family	Receptor kinases, CD molecules (CD), Immunoglobulin superfamily domain containing
Name	fms-related tyrosine kinase 3
Description	This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FLT3 is a receptor tyrosine kinase expressed on hematopoietic progenitor cells, where it normally participates in regulating proliferation and differentiation during hematopoiesis. Activation of FLT3 by its ligand supports the expansion and function of dendritic cells and other immune effectors, a property that has been harnessed in immunotherapeutic vaccination strategies to boost antitumor T‐cell responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In acute myeloid leukemia (AML), FLT3 is frequently mutated. Activating mutations—including internal tandem duplications (FLT3‐ITD) and point mutations in the tyrosine kinase domain (such as those at D835)—lead to constitutive receptor activation and aberrant downstream signaling. This dysregulated signaling drives unchecked proliferation, contributes to a high leukemic burden, and is associated with adverse clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, these FLT3 mutations are often observed in AML cases with a normal karyotype and may co‐occur with other genetic alterations (e.g. in NPM1), thus serving as both driver events and important prognostic biomarkers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " In addition, FLT3 is maintained as a client protein of the HSP90 chaperone complex; disruption of HSP90 function (for example, via inhibition of HDAC6 that affects HSP90 acetylation) can promote the degradation of mutant FLT3, offering a potential avenue for targeted therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the central role of FLT3 in both normal hematopoietic regulation and leukemogenesis. Its constitutive activation in AML not only defines a subset of patients with poorer prognosis but also identifies FLT3 as a critical therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael A Curran, Welby Montalvo, Hideo Yagita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0915174107"}], "href": "https://doi.org/10.1073/pnas.0915174107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20160101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20160101"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brunangelo Falini, Cristina Mecucci, Enrico Tiacci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa041974"}], "href": "https://doi.org/10.1056/NEJMoa041974"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15659725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15659725"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Y Yamamoto, H Kiyoi, Y Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v97.8.2434"}], "href": "https://doi.org/10.1182/blood.v97.8.2434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11290608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11290608"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Susanne Schnittger, Claudia Schoch, Martin Dugas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v100.1.59"}], "href": "https://doi.org/10.1182/blood.v100.1.59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12070009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12070009"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Naval Daver, Richard F Schlenk, Nigel H Russell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting FLT3 mutations in AML: review of current knowledge and evidence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-018-0357-9"}], "href": "https://doi.org/10.1038/s41375-018-0357-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30651634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30651634"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rosemary E Gale, Claire Green, Christopher Allen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-08-109090"}], "href": "https://doi.org/10.1182/blood-2007-08-109090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957027"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Susanne Schnittger, Claudia Schoch, Wolfgang Kern, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-06-2248"}], "href": "https://doi.org/10.1182/blood-2005-06-2248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16076867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16076867"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Christian Thiede, Sina Koch, Eva Creutzig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-08-3167"}], "href": "https://doi.org/10.1182/blood-2005-08-3167"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16455956"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16455956"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Purva Bali, Michael Pranpat, James Bradner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C500186200"}], "href": "https://doi.org/10.1074/jbc.C500186200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15937340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15937340"}]}]}]}
Synonyms	CD135, FLK-2, FLK2
Proteins	FLT3_HUMAN
NCBI Gene ID	2322
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FLT3 has 9,669 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for FLT3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FLT3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FLT3 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FLT3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FLT3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FLT3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FLT3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FLT3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FLT3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FLT3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FLT3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FLT3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FLT3 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FLT3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FLT3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with FLT3 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FLT3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FLT3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FLT3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FLT3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FLT3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FLT3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FLT3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FLT3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FLT3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FLT3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FLT3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FLT3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FLT3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FLT3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FLT3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving FLT3 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FLT3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FLT3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FLT3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FLT3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FLT3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FLT3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FLT3 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FLT3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FLT3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FLT3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.