FMNL2 Gene

Name	formin-like 2
Description	This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FMNL2 is a diaphanous‐related formin that has emerged as a key regulator of actin cytoskeletal dynamics in multiple cellular contexts, particularly in cancer. In colorectal cancer and lung adenocarcinoma, for example, FMNL2 is up‐regulated and contributes to tumor progression by modulating cell motility, invasion, and epithelial–mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n Its primary function as an actin filament elongation factor is underscored by its accumulation at the tips of lamellipodia and filopodia, where it drives the rapid assembly and turnover of actin filaments required for membrane protrusion and cell–cell adhesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n FMNL2 acts downstream of specific Rho GTPases such as RhoC and Cdc42, thereby transmitting signals that promote mesenchymal motility and coordinate cytoskeletal rearrangements essential for invasive behavior. Indeed, FMNL2 has been identified as a RhoC‐specific effector that modulates rounded invasiveness in three‐dimensional environments and facilitates TGF–β–induced EMT in colorectal carcinoma cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Expression and activity of FMNL2 are tightly controlled by several microRNAs—including miR–145, miR–137, miR–34a, miR–206, and miR–204–3p—that directly target its messenger RNA, thereby impacting key signaling pathways such as PI3K/Akt, MAPK, and NF–κB. These post–transcriptional mechanisms help fine–tune cytoskeletal assembly and, consequently, cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the level of actin assembly, FMNL2 cooperates with proteins such as capping protein, cortactin, and fascin to regulate the formation and stabilization of filopodia and invadopodia—specialized protrusive structures that mediate cell adhesion and extracellular matrix degradation, critical steps in cancer metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n In addition, FMNL2 appears to have roles beyond protrusion dynamics; for instance, it contributes to maintaining cellular polarity and proper vesicular trafficking at the Golgi apparatus."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although up–regulation of FMNL2 typically correlates with aggressive tumor behavior—as seen in colorectal and lung cancers—in some tumor types, such as hepatocellular carcinoma, lower FMNL2 expression has been linked to poorer differentiation and overall survival, suggesting a context–dependent role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n Collectively, these findings reveal that FMNL2 is a multifunctional actin elongator whose regulated expression and activity are essential for orchestrating the morphological and migratory changes underpinning cancer cell invasion and metastasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huijun Xie, Xiaoli Ren, Sainan Xin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8589"}], "href": "https://doi.org/10.18632/oncotarget.8589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27058418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27058418"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Li Liang, Xianzheng Li, Xiaojing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2012.11.033"}], "href": "https://doi.org/10.1053/j.gastro.2012.11.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23201162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23201162"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xi-Ling Zhu, Li Liang, Yan-Qing Ding "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Colorectal Dis (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00384-008-0520-2"}], "href": "https://doi.org/10.1007/s00384-008-0520-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18665374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18665374"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qingjun Meng, Mingming Ren, Yanguang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-RMRP Acts as an Oncogene in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0164845"}], "href": "https://doi.org/10.1371/journal.pone.0164845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27906963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27906963"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jennifer Block, Dennis Breitsprecher, Sonja Kühn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FMNL2 drives actin-based protrusion and migration downstream of Cdc42."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2012.03.064"}], "href": "https://doi.org/10.1016/j.cub.2012.03.064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22608513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22608513"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sonja Kühn, Constanze Erdmann, Frieda Kage, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8088"}], "href": "https://doi.org/10.1038/ncomms8088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25963737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25963737"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Katharina Grikscheit, Tanja Frank, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201412015"}], "href": "https://doi.org/10.1083/jcb.201412015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25963818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25963818"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Karin Pfisterer, James Levitt, Campbell D Lawson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FMNL2 regulates dynamics of fascin in filopodia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201906111"}], "href": "https://doi.org/10.1083/jcb.201906111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32294157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32294157"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "T M Kitzing, Y Wang, O Pertz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.515"}], "href": "https://doi.org/10.1038/onc.2009.515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20101212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20101212"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yufa Li, Xiling Zhu, Yuanfeng Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FMNL2 enhances invasion of colorectal carcinoma by inducing epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-10-0081"}], "href": "https://doi.org/10.1158/1541-7786.MCR-10-0081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21071512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21071512"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Emma F Woodham, Nikki R Paul, Benjamin Tyrrell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2017.01.033"}], "href": "https://doi.org/10.1016/j.cub.2017.01.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28238662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28238662"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "GuiFeng Lu, YaLing Sun, ShengLi An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2015.06.014"}], "href": "https://doi.org/10.1016/j.yexmp.2015.06.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26103003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26103003"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "X L Ren, G Y He, X M Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-206 functions as a tumor suppressor in colorectal cancer by targeting FMNL2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-015-2053-8"}], "href": "https://doi.org/10.1007/s00432-015-2053-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26515696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26515696"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yan Yan, Zhongmiao Wang, Baoli Qin "}, {"type": "b", "children": [{"type": "t", "text": "A novel long noncoding RNA, LINC00483 promotes proliferation and metastasis via modulating of FMNL2 in CRC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.12.090"}], "href": "https://doi.org/10.1016/j.bbrc.2018.12.090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30594388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30594388"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shashank Shekhar, Mikael Kerleau, Sonja Kühn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formin and capping protein together embrace the actin filament in a ménage à trois."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9730"}], "href": "https://doi.org/10.1038/ncomms9730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26564775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26564775"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "X L Ren, Y D Qiao, J Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cortactin recruits FMNL2 to promote actin polymerization and endosome motility in invadopodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.01.023"}], "href": "https://doi.org/10.1016/j.canlet.2018.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29374558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29374558"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Frieda Kage, Anika Steffen, Adolf Ellinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-09952-1"}], "href": "https://doi.org/10.1038/s41598-017-09952-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28852060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28852060"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Li Liang, Jian Guan, Yuanfeng Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of formin-like 2 predicts poor prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.humpath.2010.08.025"}], "href": "https://doi.org/10.1016/j.humpath.2010.08.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21496865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21496865"}]}]}]}
Synonyms	FHOD2
Proteins	FMNL2_HUMAN
NCBI Gene ID	114793
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FMNL2 has 10,786 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for FMNL2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FMNL2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FMNL2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FMNL2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FMNL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FMNL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FMNL2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FMNL2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FMNL2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FMNL2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FMNL2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FMNL2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FMNL2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FMNL2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FMNL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FMNL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FMNL2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FMNL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FMNL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FMNL2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FMNL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FMNL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FMNL2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with FMNL2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FMNL2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FMNL2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FMNL2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FMNL2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FMNL2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FMNL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FMNL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FMNL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FMNL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FMNL2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FMNL2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FMNL2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FMNL2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FMNL2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FMNL2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FMNL2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing FMNL2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of FMNL2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.