FMO3 Gene

Name	flavin containing monooxygenase 3
Description	Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Flavin‐containing monooxygenase 3 (FMO3) is a hepatic enzyme that catalyzes the NADPH‐dependent N‐oxygenation of soft‐nucleophilic substrates, most notably converting gut microbiota–derived trimethylamine (TMA) to trimethylamine N‐oxide (TMAO), as well as oxidizing various xenobiotics and drugs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Regulation of FMO3 expression is tightly linked to metabolic status; for example, insulin suppresses its expression, whereas in obesity and insulin‐resistant states its up‐regulation leads to increased TMAO production. This elevation in TMAO is implicated in the activation of key metabolic regulators—such as the transcription factor FoxO1 and the endoplasmic reticulum stress kinase PERK—and is associated with hyperglycemia, hyperlipidemia, atherosclerosis, and adverse cardiovascular outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, FMO3 influences hepatic lipid and glucose homeostasis by modulating pathways involved in lipogenesis and gluconeogenesis, with studies implicating additional transcription factors such as PPARα and Kruppel‐like factor 15 in these processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic variation in the FMO3 gene can markedly alter enzyme functionality. Variants that impair FMO3 activity lead to deficient TMA oxidation and cause trimethylaminuria (also known as “fish odor syndrome”), while other polymorphisms have been associated with altered circulating TMAO levels that may modify risks for cardiovascular and thrombotic events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " In addition, detailed genotype–phenotype analyses in various populations have provided insights into FMO3’s structure–function relationships and its contribution to interindividual differences in drug metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in endogenous metabolite regulation, FMO3 participates in the clearance of therapeutic agents. It contributes to the metabolism of drugs such as teneligliptin, busulfan, and nicotine—thereby affecting their pharmacokinetics and therapeutic outcomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": " Furthermore, FMO3 expression may be influenced by nuclear receptors such as FXR and is induced under xenobiotic stress—for example, in conditions of acetaminophen-induced liver injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the multifunctional nature of FMO3 at the intersection of host metabolic regulation, xenobiotic detoxification, and cardiovascular risk. As such, FMO3 has emerged as a potential therapeutic target for the treatment of metabolic disorders and for optimizing drug metabolism, while its genetic variants continue to shed light on the pathogenesis of both inherited conditions (e.g., trimethylaminuria) and acquired cardiometabolic diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroshi Yamazaki, Makiko Shimizu "}, {"type": "b", "children": [{"type": "t", "text": "Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2013.03.020"}], "href": "https://doi.org/10.1016/j.bcp.2013.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23567996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23567996"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianhua Zhou, Elizabeth A Shephard "}, {"type": "b", "children": [{"type": "t", "text": "Mutation, polymorphism and perspectives for the future of human flavin-containing monooxygenase 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mutat Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mrrev.2005.09.001"}], "href": "https://doi.org/10.1016/j.mrrev.2005.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16481213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16481213"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ji Miao, Alisha V Ling, Praveen V Manthena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7498"}], "href": "https://doi.org/10.1038/ncomms7498"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25849138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25849138"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sifan Chen, Ayana Henderson, Michael C Petriello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2019.08.021"}], "href": "https://doi.org/10.1016/j.cmet.2019.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31543404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31543404"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Diana M Shih, Zeneng Wang, Richard Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M051680"}], "href": "https://doi.org/10.1194/jlr.M051680"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25378658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25378658"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Makiko Shimizu, Hiroshi Yano, Satomi Nagashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.106.013094"}], "href": "https://doi.org/10.1124/dmd.106.013094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17142560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17142560"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Catherine K Yeung, Elinor T Adman, Allan E Rettie "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2007.04.014"}], "href": "https://doi.org/10.1016/j.abb.2007.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17531949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17531949"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Meike S Motika, Jun Zhang, Xueying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants of the human flavin-containing monooxygenase 3 (FMO3) gene associated with trimethylaminuria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2009.02.006"}], "href": "https://doi.org/10.1016/j.ymgme.2009.02.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19321370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19321370"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "E K Vialykh, M A Solidolova, O Iu Bushueva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zh Nevrol Psikhiatr Im S S Korsakova (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23390647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23390647"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Makiko Shimizu, John R Cashman, Hiroshi Yamazaki "}, {"type": "b", "children": [{"type": "t", "text": "Transient trimethylaminuria related to menstruation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-8-2"}], "href": "https://doi.org/10.1186/1471-2350-8-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17257434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17257434"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Makiko Shimizu, Charles K Allerston, Elizabeth A Shephard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Clin Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bcp.12240"}], "href": "https://doi.org/10.1111/bcp.12240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24028545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24028545"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Makiko Shimizu, Haruka Fujita, Takahiko Aoyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three novel single nucleotide polymorphisms of the FMO3 gene in a Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Pharmacokinet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2133/dmpk.21.245"}], "href": "https://doi.org/10.2133/dmpk.21.245"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16858129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16858129"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yoshinobu Nakamaru, Yoshiharu Hayashi, Ruriko Ikegawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolism and disposition of the dipeptidyl peptidase IV inhibitor teneligliptin in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xenobiotica (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/00498254.2013.816891"}], "href": "https://doi.org/10.3109/00498254.2013.816891"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23855261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23855261"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ibrahim El-Serafi, Ylva Terelius, Manuchehr Abedi-Valugerdi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0187294"}], "href": "https://doi.org/10.1371/journal.pone.0187294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29121650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29121650"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yadira X Perez-Paramo, Gang Chen, Joseph H Ashmore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nicotine-"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "N"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "'-Oxidation by Flavin Monooxygenase Enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-18-0669"}], "href": "https://doi.org/10.1158/1055-9965.EPI-18-0669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30381441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30381441"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Swetha Rudraiah, Philip R Rohrer, Igor Gurevich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/toxsci/kfu124"}], "href": "https://doi.org/10.1093/toxsci/kfu124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24973094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24973094"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yanjun Jiang, Jingling Jin, Polina Iakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Ageing Dev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mad.2013.08.003"}], "href": "https://doi.org/10.1016/j.mad.2013.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24007921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24007921"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rebecca C Schugar, Diana M Shih, Manya Warrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.05.077"}], "href": "https://doi.org/10.1016/j.celrep.2017.05.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28636934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28636934"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Cassianne Robinson-Cohen, Richard Newitt, Danny D Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0161074"}], "href": "https://doi.org/10.1371/journal.pone.0161074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27513517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27513517"}]}]}]}
Synonyms	TMAU, FMOII, DJ127D3.1
Proteins	FMO3_HUMAN
NCBI Gene ID	2328
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FMO3 has 4,285 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for FMO3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FMO3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FMO3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FMO3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FMO3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FMO3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FMO3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FMO3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FMO3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FMO3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FMO3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FMO3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FMO3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FMO3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FMO3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FMO3 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FMO3 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FMO3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FMO3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FMO3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FMO3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FMO3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FMO3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FMO3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FMO3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FMO3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FMO3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FMO3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FMO3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FMO3 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FMO3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FMO3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FMO3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FMO3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FMO3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FMO3 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FMO3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FMO3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FMO3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GAD Gene-Disease Associations	diseases associated with FMO3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FMO3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FMO3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.