FNDC3B Gene

HGNC Family	Fibronectin type III domain containing
Name	fibronectin type III domain containing 3B
Description	Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Fibronectin type III domain‐containing 3B (FNDC3B) and its circular RNA isoforms have emerged as multifaceted regulators of cell behavior in diverse biological contexts. In hepatocellular carcinoma, for example, FNDC3B is functionally linked to the regulation of cell motility, with its repression by microRNA‐143—as induced by NF‐κB—notably enhancing invasion and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the eye, genetic variations in the FNDC3B locus have been associated with conditions such as keratoconus and primary open‐angle glaucoma, suggesting that this gene may contribute to extracellular matrix integrity and corneal homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Circular RNA species derived from FNDC3B (circFNDC3B) exhibit context‐dependent roles in cancer. In bladder cancer, circFNDC3B acts as a tumor suppressor by sponging miR‐1178–3p to downregulate the oncogene G3BP2 and, in turn, inhibit SRC/FAK signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, in gastric cancer, overexpression of circFNDC3B promotes cell migration and invasion by reducing E‐cadherin expression and modulating CD44 levels via interactions with RNA‐binding factors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and similar mechanisms involving miRNA sponging have been observed with circFNDC3B in vascular smooth muscle cell injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its circular RNA forms, FNDC3B overexpression in solid tumors such as hepatocellular carcinoma and nasopharyngeal carcinoma promotes oncogenic transformation and epithelial‐to‐mesenchymal transition (EMT) by activating multiple downstream pathways including PI3K/Akt, TGFβ, and Wnt/β‐catenin signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " In oral tongue squamous cell carcinoma, hypoxia‐induced HIF‐1α upregulates FNDC3B expression, thereby promoting EMT and contributing to metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, FNDC3B is subject to regulation by microRNAs and long noncoding RNAs that modulate its expression in various contexts. For instance, miR‐215–5p targets FNDC3B during early adipocyte differentiation, serving as a negative regulator of adipogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while in glioma, the long noncoding RNA LINC00355 functions as a competing endogenous RNA to modulate FNDC3B levels and thereby promote tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore that FNDC3B and its circRNA derivatives contribute to key processes such as cell adhesion, migration, invasion, and EMT across multiple tissue types and disease states. Their diverse roles in oncogenesis and tissue homeostasis render them promising biomarkers and potential therapeutic targets for cancer metastasis and other pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoying Zhang, Shanrong Liu, Tingsong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.23008"}], "href": "https://doi.org/10.1002/hep.23008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19472311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19472311"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yi Lu, Veronique Vitart, Kathryn P Burdon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2506"}], "href": "https://doi.org/10.1038/ng.2506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23291589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23291589"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongwei Liu, Junming Bi, Wei Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-018-0908-8"}], "href": "https://doi.org/10.1186/s12943-018-0908-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30458784"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30458784"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoli Hu, Yingqun Zhong, Yuanyuan Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-019-1278-x"}], "href": "https://doi.org/10.1186/s13287-019-1278-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31196201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31196201"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yiming Liu, Zhen Zhong, Lun Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Heart J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1536/ihj.21-186"}], "href": "https://doi.org/10.1536/ihj.21-186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34789642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34789642"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Chunlin Cai, Megha Rajaram, Xin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.20121"}], "href": "https://doi.org/10.4161/cc.20121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22510613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22510613"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ying-Qing Li, Yang Chen, Ya-Fei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14394"}], "href": "https://doi.org/10.1111/cas.14394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32232887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32232887"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chin-Hui Lin, Yao-Wen Lin, Ying-Chun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.10374"}], "href": "https://doi.org/10.18632/oncotarget.10374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27385217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27385217"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhaoming Zhong, Hongxing Zhang, Min Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2018.6231"}], "href": "https://doi.org/10.3892/or.2018.6231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29393475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29393475"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yongdong Peng, Huanan Li, Xianglong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2016.08.014"}], "href": "https://doi.org/10.1016/j.biocel.2016.08.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27521659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27521659"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhen-Yong Qi, Li-Li Wang, Xu-Liang Qu "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LINC00355 Acts as a Novel Biomarker and Promotes Glioma Biological Activities via the Regulation of miR-1225/FNDC3B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1683129"}], "href": "https://doi.org/10.1155/2021/1683129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34603558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34603558"}]}]}]}
Synonyms	FAD104, YVTM2421, PRO4979
Proteins	FND3B_HUMAN
NCBI Gene ID	64778
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FNDC3B has 20,420 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for FNDC3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FNDC3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FNDC3B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FNDC3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FNDC3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FNDC3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FNDC3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FNDC3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FNDC3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FNDC3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FNDC3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FNDC3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FNDC3B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FNDC3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FNDC3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FNDC3B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FNDC3B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FNDC3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FNDC3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FNDC3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing FNDC3B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FNDC3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FNDC3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FNDC3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FNDC3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FNDC3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FNDC3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FNDC3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FNDC3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FNDC3B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FNDC3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FNDC3B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FNDC3B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FNDC3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FNDC3B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FNDC3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FNDC3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FNDC3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FNDC3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FNDC3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FNDC3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FNDC3B gene from the ENCODE Histone Modification Site Profiles dataset.