FOXF1 Gene

HGNC Family	Forkhead boxes (FOX)
Name	forkhead box F1
Description	This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FOXF1 is a forkhead transcription factor expressed predominantly in mesenchymal cells that plays essential roles during embryogenesis and in adult tissue homeostasis. It is critical for proper lung and vascular development, as mutations or deletions in FOXF1 are associated with lethal developmental disorders—such as alveolar capillary dysplasia with misalignment of pulmonary veins—and congenital anomalies affecting multiple organs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In extraembryonic mesoderm, FOXF1 is required to activate Bmp4 expression, thereby promoting vasculogenesis. Moreover, FOXF1 expression in hepatic stellate cells and gallbladder mesenchyme indicates its involvement in mesenchymal–epithelial signaling crucial for liver repair and gallbladder development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its developmental roles, FOXF1 functions in the regulation of mesenchymal cell migration by directly activating the integrin‐β3 (Itgbeta3) promoter to support proper cell adhesion and migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In the adult lung, FOXF1 contributes to the maintenance of the alveolar architecture through regulation of junctional proteins and by limiting myofibroblast invasion, thereby inhibiting pulmonary fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of tumor biology, studies have demonstrated that FOXF1 can act as a tumor suppressor. In lung cancer models, for example, upregulation of FOXF1 following the fusion of mesenchymal stem cells to cancer cells contributes to reprogramming that restores p21 function and promotes differentiation, ultimately suppressing malignant growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings establish FOXF1 as a key regulatory factor that orchestrates mesenchymal cell functions—including control of cell adhesion, migration, and differentiation—to guide organogenesis, vascular formation, tissue repair, and modulation of tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paweł Stankiewicz, Partha Sen, Samarth S Bhatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.05.005"}], "href": "https://doi.org/10.1016/j.ajhg.2009.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19500772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19500772"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jeanette Astorga, Peter Carlsson "}, {"type": "b", "children": [{"type": "t", "text": "Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.004432"}], "href": "https://doi.org/10.1242/dev.004432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17881493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17881493"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Vladimir V Kalinichenko, Dibyendu Bhattacharyya, Yan Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/jhep.2003.50005"}], "href": "https://doi.org/10.1053/jhep.2003.50005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12500195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12500195"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dmitriy Malin, Il-Man Kim, Evan Boetticher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01736-06"}], "href": "https://doi.org/10.1128/MCB.01736-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17261592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17261592"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Markaisa Black, David Milewski, Tien Le, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXF1 Inhibits Pulmonary Fibrosis by Preventing CDH2-CDH11 Cadherin Switch in Myofibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.03.067"}], "href": "https://doi.org/10.1016/j.celrep.2018.03.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29642003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29642003"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Roy-Akira Saito, Patrick Micke, Janna Paulsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3644"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3644"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20233876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20233876"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yali Song, Xiaoling Li, Zhaoyang Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9170"}], "href": "https://doi.org/10.18632/oncotarget.9170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27167345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27167345"}]}]}]}
Synonyms	ACDMPV, FREAC1, FKHL5
Proteins	FOXF1_HUMAN
NCBI Gene ID	2294
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FOXF1 has 7,139 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.

Click the + buttons to view associations for FOXF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FOXF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOXF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOXF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FOXF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FOXF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FOXF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FOXF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FOXF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FOXF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FOXF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FOXF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FOXF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FOXF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FOXF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FOXF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FOXF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with FOXF1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with FOXF1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FOXF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FOXF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FOXF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FOXF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FOXF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FOXF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FOXF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FOXF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FOXF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FOXF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with FOXF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FOXF1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FOXF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FOXF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FOXF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FOXF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FOXF1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FOXF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FOXF1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FOXF1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FOXF1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FOXF1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FOXF1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.