FUBP1 Gene

Name	far upstream element (FUSE) binding protein 1
Description	The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n FUBP1 (Far‐Upstream Element–Binding Protein 1) is a multifunctional regulator of gene expression that acts primarily through binding to the far‐upstream element (FUSE) in target promoters—most notably that of the proto‐oncogene MYC. In gliomas, especially in lower‐grade and oligodendroglial tumors, somatic mutations in FUBP1 are observed in conjunction with IDH mutations and 1p/19q codeletion, delineating a distinct molecular subgroup with important prognostic implications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": " Conversely, in a range of other malignancies such as lung, breast, and liver cancers, elevated FUBP1 expression has been linked to enhanced MYC transcription, stimulation of cell proliferation, and inhibition of apoptotic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, post‐translational regulation of FUBP1 through ubiquitination—mediated by proteins such as USP22 and parkin—further underscores its role in modulating critical cell cycle regulators like p21 and links its function to broader signaling pathways involved in both tumorigenesis and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In addition, emerging evidence indicates that FUBP1 can be recruited by oncogenic long non‐coding RNAs to the MYC promoter, thereby accentuating its contribution to aggressive cancer phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these studies characterize FUBP1 as a pivotal mediator of oncogenic transcriptional programs whose aberrant mutation or overexpression contributes to tumor development, progression, and patient outcome across diverse cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel J Brat, Roel G W Verhaak, Kenneth D Aldape, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa1402121"}], "href": "https://doi.org/10.1056/NEJMoa1402121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26061751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26061751"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuchen Jiao, Patrick J Killela, Zachary J Reitman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.588"}], "href": "https://doi.org/10.18632/oncotarget.588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22869205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22869205"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CIC and FUBP1 contribute to human oligodendroglioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1210557"}], "href": "https://doi.org/10.1126/science.1210557"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21817013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21817013"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Felix Sahm, Christian Koelsche, Jochen Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-012-0993-5"}], "href": "https://doi.org/10.1007/s00401-012-0993-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22588899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22588899"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "P Baumgarten, P N Harter, M Tönjes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropathol Appl Neurobiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/nan.12088"}], "href": "https://doi.org/10.1111/nan.12088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24117486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24117486"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Le Zhang, Ying Liu, Mengning Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjx056"}], "href": "https://doi.org/10.1093/jmcb/mjx056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29272522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29272522"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J Zhang, Q M Chen "}, {"type": "b", "children": [{"type": "t", "text": "Far upstream element binding protein 1: a commander of transcription, translation and beyond."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.350"}], "href": "https://doi.org/10.1038/onc.2012.350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22926519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22926519"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "L Venturutti, R I Cordo Russo, M A Rivas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.151"}], "href": "https://doi.org/10.1038/onc.2016.151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27157613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27157613"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zongmei Ding, Xiancheng Liu, Yonghua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of far upstream element (FUSE) binding protein 1 in human glioma is correlated with c-Myc and cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22114"}], "href": "https://doi.org/10.1002/mc.22114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24347226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24347226"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Boyko S Atanassov, Sharon Y R Dent "}, {"type": "b", "children": [{"type": "t", "text": "USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2011.140"}], "href": "https://doi.org/10.1038/embor.2011.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21779003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21779003"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Han Seok Ko, Seong Who Kim, Sathya R Sriram, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of far upstream element-binding protein-1 as an authentic Parkin substrate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C600041200"}], "href": "https://doi.org/10.1074/jbc.C600041200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16672220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16672220"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Xinyi Qian, Juze Yang, Qiongzi Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-021-01123-0"}], "href": "https://doi.org/10.1186/s13045-021-01123-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34274028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34274028"}]}]}]}
Synonyms	HDH V, FUBP
Proteins	FUBP1_HUMAN
NCBI Gene ID	8880
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FUBP1 has 9,700 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for FUBP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FUBP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FUBP1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FUBP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FUBP1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FUBP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FUBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FUBP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FUBP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FUBP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FUBP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FUBP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FUBP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FUBP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FUBP1 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FUBP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FUBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FUBP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FUBP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FUBP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FUBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FUBP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FUBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FUBP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FUBP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FUBP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FUBP1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FUBP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FUBP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FUBP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FUBP1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FUBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FUBP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FUBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FUBP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for FUBP1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FUBP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FUBP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FUBP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FUBP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of FUBP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with FUBP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.