FYN Gene

HGNC Family	SH2 domain containing
Name	FYN proto-oncogene, Src family tyrosine kinase
Description	This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Fyn, a member of the Src family of tyrosine kinases, performs multiple context‐dependent roles that span neuronal, immune, and cancer cell signaling. In the nervous system, Fyn is critical for postsynaptic signal transduction where it is targeted by tau to the dendritic compartment, thereby modulating NMDA receptor function and mediating excitotoxicity in Alzheimer’s disease (AD) models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, increased Fyn activity has been shown to exacerbate synaptic dysfunction, network hyperexcitability, and cognitive deficits in AD, while its aberrant kinase activity also phosphorylates tau at tyrosine residues early in development and in disease, contributing to the formation of neurofibrillary tangles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Fyn additionally serves as a molecular link in hippocampal signaling by connecting brain-derived neurotrophic factor (BDNF)/TrkB activation with NR2B-containing NMDA receptors, thus influencing synaptic plasticity and memory consolidation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, Fyn participates in neuronal guidance pathways; for example, semaphorin-3A signals require the coordinated action of Fyn and Cdk5 to mediate growth cone collapse, and in the Reelin cascade, Fyn is activated downstream of Reelin receptors to phosphorylate the adaptor protein Dab1, facilitating proper neuronal migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its neuronal functions, Fyn is a key regulator of antioxidant responses. Phosphorylation of Fyn by upstream kinases such as GSK3β instigates its nuclear localization, leading to phosphorylation of Nrf2 and subsequent nuclear export and degradation of this transcription factor; such mechanisms modulate cellular defense against oxidative stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In cardiomyocytes, an AKT/GSK3β/Fyn/Nrf2 axis has been implicated in the attenuation of doxorubicin-induced oxidative damage and apoptosis, suggesting that Fyn functions within broader cytoprotective signaling networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Fyn also exerts important regulatory effects in the immune system. It is recruited by the adaptor protein SAP during engagement of SLAM family receptors, a process that is essential for natural killer T (NKT) cell development; SAP deficiency, which impairs Fyn recruitment, is associated with immunodeficiencies such as X-linked lymphoproliferative syndrome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In addition, Fyn is part of a signaling cascade initiated by the binding of fibrillar β-amyloid to CD36 on microglia, leading to the production of reactive oxygen species and proinflammatory mediators."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, Fyn has been implicated in cancer-related signaling pathways. Recurrent mutations in the FYN gene have been observed in peripheral T cell lymphomas, implicating aberrant Src family signaling in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In solid tumors, Fyn functions downstream of noncanonical Wnt receptors (e.g., Fzd2) to promote epithelial-to-mesenchymal transition and metastasis, highlighting its role in cancer cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Additionally, during integrin-mediated mechanotransduction, Fyn is activated in response to force, where it regulates the activity of guanine nucleotide exchange factors that modulate cytoskeletal dynamics and cellular reinforcement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lars M Ittner, Yazi D Ke, Fabien Delerue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.06.036"}], "href": "https://doi.org/10.1016/j.cell.2010.06.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20655099"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20655099"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Erik D Roberson, Brian Halabisky, Jong W Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4152-10.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.4152-10.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21228179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21228179"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gloria Lee, Ramasamy Thangavel, Vandana M Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of tau by fyn: implications for Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4162-03.2004"}], "href": "https://doi.org/10.1523/JNEUROSCI.4162-03.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14999081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14999081"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kiyofumi Yamada, Toshitaka Nabeshima "}, {"type": "b", "children": [{"type": "t", "text": "Brain-derived neurotrophic factor/TrkB signaling in memory processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1254/jphs.91.267"}], "href": "https://doi.org/10.1254/jphs.91.267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12719654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12719654"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yukio Sasaki, Chi Cheng, Yutaka Uchida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(02)00857-7"}], "href": "https://doi.org/10.1016/s0896-6273(02"}, {"type": "t", "text": "00857-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12372285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12372285"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hans H Bock, Joachim Herz "}, {"type": "b", "children": [{"type": "t", "text": "Reelin activates SRC family tyrosine kinases in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0960-9822(02)01403-3"}], "href": "https://doi.org/10.1016/s0960-9822(02"}, {"type": "t", "text": "01403-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12526740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12526740"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Suryakant K Niture, Raju Khatri, Anil K Jaiswal "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Nrf2-an update."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2013.02.008"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2013.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23434765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23434765"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xin Zhang, Can Hu, Chun-Yan Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-019-0372-z"}], "href": "https://doi.org/10.1038/s41418-019-0372-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31209361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31209361"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Benoit Pasquier, Luo Yin, Marie-Claude Fondanèche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20042432"}], "href": "https://doi.org/10.1084/jem.20042432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15738056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15738056"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Betty Chan, Arpad Lanyi, Hyun Kyu Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAP couples Fyn to SLAM immune receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb920"}], "href": "https://doi.org/10.1038/ncb920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12545174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12545174"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kathryn J Moore, Joseph El Khoury, Lea A Medeiros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208788200"}], "href": "https://doi.org/10.1074/jbc.M208788200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12239221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12239221"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Juan M Cordovez, Lina Maria Rendon, Camila Gonzalez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Using the basic reproduction number to assess the effects of climate change in the risk of Chagas disease transmission in Colombia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Trop (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.actatropica.2013.10.003"}], "href": "https://doi.org/10.1016/j.actatropica.2013.10.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24416781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24416781"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Taranjit S Gujral, Marina Chan, Leonid Peshkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.10.032"}], "href": "https://doi.org/10.1016/j.cell.2014.10.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25417160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25417160"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Christophe Guilluy, Vinay Swaminathan, Rafael Garcia-Mata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2254"}], "href": "https://doi.org/10.1038/ncb2254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21572419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21572419"}]}]}]}
Synonyms	P59-FYN, SYN, SLK
Proteins	FYN_HUMAN
NCBI Gene ID	2534
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FYN has 15,361 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 150 datasets.

Click the + buttons to view associations for FYN from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FYN Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by FYN gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FYN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FYN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FYN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FYN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FYN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FYN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving FYN protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FYN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FYN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FYN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FYN gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FYN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FYN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with FYN gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FYN protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FYN gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FYN gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FYN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FYN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing FYN protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FYN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FYN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FYN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing FYN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing FYN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FYN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FYN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing FYN protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of FYN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FYN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FYN gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FYN gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with FYN gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FYN protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FYN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate FYN protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving FYN gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving FYN gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FYN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.