FZD7 Gene

HGNC Family	G protein-coupled receptors
Name	frizzled class receptor 7
Description	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Frizzled‐7 (FZD7) functions as a pivotal receptor for Wnt ligands in both normal stem cell regulation and cancer biology. In skeletal muscle, FZD7 is expressed by quiescent satellite stem cells and, together with coreceptors such as Syndecan‐4, mediates the action of Wnt7a to stimulate the symmetric expansion of satellite stem cells and to orchestrate niche remodeling essential for effective muscle regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cancer, increased FZD7 expression is frequently observed in aggressive tumors. For example, in triple‐negative breast cancer and basal‐like breast tumors, FZD7 promotes canonical Wnt/β‐catenin signaling that supports tumor cell proliferation, invasiveness, and cancer stem cell properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in hepatocellular carcinoma and colorectal cancer, FZD7 forms functional complexes with specific Wnt ligands (such as Wnt3) to activate β‐catenin‐dependent transcription, thereby enhancing tumorigenesis, cell survival, and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": " In addition, FZD7 is enriched in intestinal Lgr5+ stem cells where its engagement with Wnt3 or Wnt2b supports robust Wnt signaling required for stem cell maintenance and intestinal homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, FZD7 levels and activity can be modulated post‐transcriptionally by specific microRNAs, which in turn influence downstream signaling pathways that affect tumor drug sensitivity and differentiation programs in myogenic cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted role of FZD7 as a master regulator of Wnt signaling across distinct biological contexts—from promoting stem cell expansion and tissue regeneration to driving oncogenic processes—and highlight its potential as an attractive biomarker and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fabien Le Grand, Andrew E Jones, Vanessa Seale, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2009.03.013"}], "href": "https://doi.org/10.1016/j.stem.2009.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19497282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19497282"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "C Florian Bentzinger, Yu Xin Wang, Julia von Maltzahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibronectin regulates Wnt7a signaling and satellite cell expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2012.09.015"}], "href": "https://doi.org/10.1016/j.stem.2012.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23290138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23290138"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "L Yang, X Wu, Y Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FZD7 has a critical role in cell proliferation in triple negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.145"}], "href": "https://doi.org/10.1038/onc.2011.145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21532620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21532620"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Florian Bentzinger, Julia von Maltzahn, Nicolas A Dumont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201310035"}], "href": "https://doi.org/10.1083/jcb.201310035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24711502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24711502"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Miran Kim, Han Chu Lee, Orkhontuya Tsedensodnom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2007.12.020"}], "href": "https://doi.org/10.1016/j.jhep.2007.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18313787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18313787"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Philippe Merle, Miran Kim, Marc Herrmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2005.05.018"}], "href": "https://doi.org/10.1016/j.jhep.2005.05.018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16098625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16098625"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Koji Ueno, Mikako Hiura, Yutaka Suehiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frizzled-7 as a potential therapeutic target in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.08320"}], "href": "https://doi.org/10.1593/neo.08320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18592008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18592008"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "K Ueno, S Hazama, S Mitomori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjc.6605307"}], "href": "https://doi.org/10.1038/sj.bjc.6605307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19773752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19773752"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dustin J Flanagan, Toby J Phesse, Nick Barker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Reports (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stemcr.2015.03.003"}], "href": "https://doi.org/10.1016/j.stemcr.2015.03.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25892522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25892522"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Katarzyna Goljanek-Whysall, Helio Pais, Tina Rathjen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.101758"}], "href": "https://doi.org/10.1242/jcs.101758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22595520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22595520"}]}]}]}
Synonyms	FZE3
Proteins	FZD7_HUMAN
NCBI Gene ID	8324
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

FZD7 has 10,948 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for FZD7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

FZD7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FZD7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of FZD7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of FZD7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of FZD7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of FZD7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of FZD7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of FZD7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FZD7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of FZD7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of FZD7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of FZD7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of FZD7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with FZD7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with FZD7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FZD7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of FZD7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of FZD7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of FZD7 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of FZD7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing FZD7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing FZD7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with FZD7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with FZD7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with FZD7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with FZD7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with FZD7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of FZD7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by FZD7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for FZD7 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with FZD7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with FZD7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with FZD7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with FZD7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with FZD7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at FZD7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of FZD7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of FZD7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing FZD7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with FZD7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with FZD7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.