GAGE12E Gene

Name G antigen 12E
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GAGE12E, a member of the cancer‐testis antigen family, has emerged as a multifaceted molecule with roles in both oncogenesis and development. In gastric cancer, a closely related variant (GAGE7B) is markedly overexpressed in tumors exhibiting lymph node metastasis, where its high expression correlates with advanced clinical stage and poorer patient survival. Functional studies demonstrate that GAGE7B promotes tumor metastasis, growth, and angiogenesis by activating the p38δ/pMAPKAPK2/pHSP27 signaling cascade. Moreover, GAGE7B acts as a competitive endogenous RNA by binding miR‑30c, thereby relieving miRNA‐mediated suppression of p38δ and further potentiating oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its oncogenic properties, members of the GAGE family have been identified as cancer‐testis antigens—molecules normally restricted to immune privileged germ cells that are aberrantly expressed in certain malignancies and cancer molecular subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Expression studies during early human sex differentiation have also detected GAGE protein expression in embryonic gonads, suggesting potential roles during developmental processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that GAGE12E (and its close relatives) contribute to tumor progression by engaging specific signaling pathways and by modulating microRNA activity, while also reflecting their tissue‐restricted expression patterns that make them promising candidates as both prognostic biomarkers and targets for immunotherapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Duan-Bo Shi, Ran-Ran Ma, Hui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GAGE7B promotes tumor metastasis and growth via activating the p38δ/pMAPKAPK2/pHSP27 pathway in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1125-z"}], "href": "https://doi.org/10.1186/s13046-019-1125-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30871606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30871606"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Yao, Otavia L Caballero, W K Alfred Yung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immunol Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2326-6066.CIR-13-0088"}], "href": "https://doi.org/10.1158/2326-6066.CIR-13-0088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24764584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24764584"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Linn S Mamsen, Emil H Ernst, Rehannah Borup, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Temporal expression pattern of genes during the period of sex differentiation in human embryonic gonads."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-15931-3"}], "href": "https://doi.org/10.1038/s41598-017-15931-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29162857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29162857"}]}]}]}
NCBI Gene ID 729431
API
Download Associations
Predicted Functions View GAGE12E's ARCHS4 Predicted Functions.
Co-expressed Genes View GAGE12E's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View GAGE12E's ARCHS4 Predicted Functions.

Functional Associations

GAGE12E has 310 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 24 datasets.

Click the + buttons to view associations for GAGE12E from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of GAGE12E gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of GAGE12E gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of GAGE12E gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of GAGE12E gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of GAGE12E gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with GAGE12E protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with GAGE12E gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with GAGE12E gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with GAGE12E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with GAGE12E gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of GAGE12E gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of GAGE12E gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of GAGE12E gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of GAGE12E gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of GAGE12E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of GAGE12E gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of GAGE12E gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of GAGE12E gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MiRTarBase microRNA Targets microRNAs targeting GAGE12E gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of GAGE12E gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of GAGE12E gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of GAGE12E gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of GAGE12E gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with GAGE12E protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.