{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Two recent transcriptomic studies have highlighted the potential oncogenic involvement of GAGE12J in distinct cancer types. In a study focusing on lung squamous carcinoma, GAGE12J was identified among the top‐ten up‐regulated genes in tumor tissues compared with normal lung tissues, suggesting that its aberrant expression may be associated with tumorigenesis and possibly lymph node metastasis (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation of gastric cancer progression, weighted gene co‑expression network analysis revealed GAGE12J as a hub gene within a significant module. Here, its transcription levels were found to be up‑regulated in atrophic gastritis relative to normal gastric mucosa but subsequently down‑regulated in full‐blown gastric cancer. Gene set enrichment analysis further implicated GAGE12J in pathways such as peroxisome function, Notch signaling, and androgen response—all of which are known to underpin mechanisms of cellular differentiation, proliferation, and malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n While other neoplasms including schwannomas, meningiomas, and malignant melanoma were examined for deregulated genes and therapeutic targets"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the specific deregulation of GAGE12J in lung and gastric cancers underscores its potential as a biomarker and a candidate for targeted therapies in these settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Xiong, Mingzhen Li, Panpan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Study on Genetype in Lung Squamous Carcinoma by High-throughput of Transcriptome Sequence]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Fei Ai Za Zhi (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3779/j.issn.1009-3419.2017.11.01"}], "href": "https://doi.org/10.3779/j.issn.1009-3419.2017.11.01"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29167000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29167000"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L H Qin, X J Zhu, L Y Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of hub genes and pathways in the development of gastric cancer by gene co‑expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Regul Homeost Agents (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.23812/20-478-A"}], "href": "https://doi.org/10.23812/20-478-A"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33601878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33601878"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Miguel Torres-Martin, Luis Lassaletta, Alberto Isla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2014.3526"}], "href": "https://doi.org/10.3892/or.2014.3526"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25333347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25333347"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fernando Gallardo, Andreina Padrón, Ricard Garcia-Carbonell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3252"}], "href": "https://doi.org/10.18632/oncotarget.3252"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25823659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25823659"}]}]}]}