GALNT6 Gene

HGNC Family	Glycosyltransferases
Name	polypeptide N-acetylgalactosaminyltransferase 6
Description	This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Polypeptide N‑acetylgalactosaminyltransferase 6 (GALNT6) is a key glycosyltransferase that catalyzes the initial step of mucin‑type O‑glycosylation by transferring N‑acetylgalactosamine to serine and threonine residues on protein substrates. Aberrant overexpression of GALNT6 has been documented in several cancers. In breast cancer, for instance, elevated GALNT6 levels promote oncogenesis by mediating the O‑glycosylation and consequent stabilization of critical oncoproteins such as mucin‑1 (MUC1) and other secreted factors, thereby reducing cell–cell adhesion and enhancing invasiveness and proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, GALNT6‐dependent modifications of oncofetal fibronectin and lectin galactoside‑binding soluble 3 binding protein (LGALS3BP) further contribute to autocrine growth stimulation and altered cellular signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of ovarian cancer, high GALNT6 expression correlates with increased recurrence, lymph node metastasis, chemoresistance, and ultimately poorer patient survival, underscoring its potential as both a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in pancreatic cancer, upregulation of GALNT6 is associated with enhanced modification of mucins (such as MUC4), activation of receptor tyrosine kinase signals, and cadherin switching that collectively promote cell viability and aggressive tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Additionally, the evolutionarily conserved but selectively expressed nature of GALNT family members highlights that, under normal conditions, GALNT6 displays a restricted expression pattern, whereas its deregulation in cancer fosters oncogenic transformation through aberrant glycosylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings indicate that GALNT6 plays a multifaceted role in cancer progression by modulating the glycosylation of key proteins involved in cell adhesion, signaling, and invasion, thereby representing a promising target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jae-Hyun Park, Toyomasa Katagiri, Suyoun Chung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1593/neo.101440"}], "href": "https://doi.org/10.1593/neo.101440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21472136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21472136"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jae-Hyun Park, Toshihiko Nishidate, Kyoko Kijima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3911"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20215525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20215525"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ryuichiro Kimura, Tetsuro Yoshimaru, Yosuke Matsushita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GALNT6‑LGALS3BP axis promotes breast cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4941"}], "href": "https://doi.org/10.3892/ijo.2019.4941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31894262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31894262"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tzu-Chi Lin, Syue-Ting Chen, Min-Chuan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16585"}], "href": "https://doi.org/10.18632/oncotarget.16585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28388560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28388560"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Razan Sheta, Magdalena Bachvarova, Marie Plante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of different GalNAc‑transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.4147"}], "href": "https://doi.org/10.3892/ijo.2017.4147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29039611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29039611"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yunus Emre Tarhan, Taigo Kato, Miran Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Morphological Changes, Cadherin Switching, and Growth Suppression in Pancreatic Cancer by GALNT6 Knockdown."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2016.03.005"}], "href": "https://doi.org/10.1016/j.neo.2016.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27237318"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27237318"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "E P Bennett, H Hassan, U Mandel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (1999)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.274.36.25362"}], "href": "https://doi.org/10.1074/jbc.274.36.25362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "10464263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/10464263"}]}]}]}
Synonyms	GALNAC-T6, GALNACT6
Proteins	GALT6_HUMAN
NCBI Gene ID	11226
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GALNT6 has 8,375 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for GALNT6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GALNT6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by GALNT6 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GALNT6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GALNT6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GALNT6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GALNT6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GALNT6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GALNT6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GALNT6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GALNT6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GALNT6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GALNT6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GALNT6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GALNT6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GALNT6 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GALNT6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GALNT6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GALNT6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GALNT6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of GALNT6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GALNT6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GALNT6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GALNT6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing GALNT6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing GALNT6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GALNT6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GALNT6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GALNT6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GALNT6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with GALNT6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of GALNT6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GALNT6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GALNT6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GALNT6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GALNT6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GALNT6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GALNT6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GALNT6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GALNT6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GALNT6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with GALNT6 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.