GBP1P1 Gene

Name guanylate binding protein 1, interferon-inducible pseudogene 1
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGBP1P1 is a pseudogene‐derived long noncoding RNA that is dramatically upregulated in human lung epithelial A549 cells following influenza A virus (IAV) infection. Its induction is mediated by the JAK/STAT signaling cascade, highlighting its role as an interferon‐inducible antiviral effector. This early host response suggests that GBP1P1 participates actively in the intrinsic defense mechanisms against viral pathogens."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "GBP1P1 exerts its antiviral activity by modulating the replication environment of IAV. Experimental findings demonstrate that ectopic expression of GBP1P1 significantly suppresses IAV replication, whereas its silencing facilitates viral replication and increases virus production. This indicates that GBP1P1 is a crucial component of the host’s antiviral arsenal, directly affecting the virus life cycle."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Mechanistically, GBP1P1 is localized in the cytoplasm where it functions as a decoy molecule. It sequesters DHX9 (DExH-box helicase 9), a protein that otherwise could be co-opted by viral mRNAs to aid in replication. By trapping DHX9, GBP1P1 prevents it from interacting with the viral genome, thereby attenuating virus production. This novel insight into the function of a pseudogene-derived lncRNA reveals how noncoding RNAs can fine-tune host–virus interactions and expand our understanding of the GBPs network in antiviral defense."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaohang Yu, Jiaxin Tian, Yihe Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pseudogene GBP1P1 suppresses influenza A virus replication by acting as a protein decoy for DHX9."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.00738-24"}], "href": "https://doi.org/10.1128/jvi.00738-24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38940585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38940585"}]}]}]}
NCBI Gene ID 400759
API
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Predicted Functions View GBP1P1's ARCHS4 Predicted Functions.
Co-expressed Genes View GBP1P1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View GBP1P1's ARCHS4 Predicted Functions.

Functional Associations

GBP1P1 has 842 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 16 datasets.

Click the + buttons to view associations for GBP1P1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of GBP1P1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of GBP1P1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CellMarker Gene-Cell Type Associations cell types associated with GBP1P1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of GBP1P1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of GBP1P1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of GBP1P1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at GBP1P1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of GBP1P1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of GBP1P1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of GBP1P1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of GBP1P1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of GBP1P1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of GBP1P1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of GBP1P1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of GBP1P1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at GBP1P1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.