GDI2 Gene

Name	GDP dissociation inhibitor 2
Description	GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GDI2, also known as Rab GDP dissociation inhibitor β (and in several contexts referred to as RhoGDI2), plays a pivotal role in regulating the cycling and membrane‐association of small GTPases, thereby controlling key aspects of vesicular trafficking and signal transduction. For example, in neuronal systems, pathogenic modifications of Rab proteins that reduce their affinity for GDIs have been implicated in Parkinson’s disease, underscoring the importance of proper GDI2 function in maintaining Rab homeostasis and intracellular transport."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In cancer, altered GDI2 expression has been linked with disease progression in a tissue‐dependent manner. Elevated levels of GDI2 in patient serum and tissue samples have been associated with pancreatic carcinoma, highlighting its potential as a diagnostic and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In hematopoietic stem cells, GDI2 is incorporated into exosomes alongside molecules such as VPS33B to regulate secretory pathways that maintain stem cell “stemness” and influence leukemogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the context of cancer metastasis, functional studies in bladder, gastric, and prostate cancers have shown that GDI2 can modulate cell migration and invasion by regulating Rho GTPase activities; for instance, its ability to negatively regulate RhoC activity has been linked to suppression of metastatic colonization, whereas in other settings altered GDI2 levels correlate with enhanced epithelial–mesenchymal transition and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": " In insulin‐responsive tissues, studies indicate that although both GDI1 and GDI2 are present at the trans‐Golgi network and cell periphery, GDI2 binds its target Rab proteins, such as Rab10, with lower affinity than GDI1; moreover, increased GDI2 expression in omental adipose tissue has been linked to impaired Rab18–lipid droplet interactions and insulin resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Additional regulatory layers are evident in pathological settings such as thyroid carcinoma, where microRNA‐mediated downregulation of GDI2 is associated with suppressed cell proliferation and invasion by modulating matrix metalloproteinase expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Furthermore, the role of GDI2 in endocytic trafficking is highlighted by its interaction with adaptor proteins (e.g., SPIN90) during EGF receptor internalization, and modifications such as ISGylation have been shown to enhance receptor recycling and sustain Akt signaling in breast cancer, thereby contributing to tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": " Finally, clinical associations of anti‐GDI2 antibodies with poor graft outcomes in kidney transplantation further emphasize the broad functional and pathological relevance of this protein."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, these studies illuminate the multifaceted roles of GDI2 in modulating GTPase activity, vesicle trafficking, signal propagation, and cellular homeostasis in both physiological processes and diverse disease states.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Martin Steger, Francesca Tonelli, Genta Ito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.12813"}], "href": "https://doi.org/10.7554/eLife.12813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26824392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26824392"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhi-Ling Sun, Yi Zhu, Fu-Qiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbapap.2007.04.001"}], "href": "https://doi.org/10.1016/j.bbapap.2007.04.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17507299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17507299"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hao Gu, Chiqi Chen, Xiaoxin Hao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI87105"}], "href": "https://doi.org/10.1172/JCI87105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27797340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27797340"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Konstadinos Moissoglu, Kevin S McRoberts, Jeremy A Meier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1397"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19276387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19276387"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hee Jun Cho, Sun-Mi Park, In-Kyu Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1733"}], "href": "https://doi.org/10.18632/oncotarget.1733"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24721928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24721928"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "In-Kyu Kim, Sun-Mi Park, Hee Jun Cho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3σ attenuates RhoGDI2-induced cisplatin resistance through activation of Erk and p38 in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.1334"}], "href": "https://doi.org/10.18632/oncotarget.1334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24185104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24185104"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chi Liu, Wei Wang, Ping Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GDI2 is a target of paclitaxel that affects tumorigenesis of prostate cancer via the p75NTR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.05.015"}], "href": "https://doi.org/10.1016/j.bbrc.2021.05.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34051575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34051575"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yu Chen, Yongqiang Deng, Jinzhong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20090624"}], "href": "https://doi.org/10.1042/BJ20090624"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19570034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19570034"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Rocío Guzmán-Ruiz, Carmen Tercero-Alcázar, Yoana Rabanal-Ruiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adipose tissue depot-specific intracellular and extracellular cues contributing to insulin resistance in obese individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201902703R"}], "href": "https://doi.org/10.1096/fj.201902703R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32293066"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32293066"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jidong Zou, Jiantong Qian, Haiyan Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑15b‑5p exerts its tumor repressive role via targeting GDI2: A novel insight into the pathogenesis of thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11343"}], "href": "https://doi.org/10.3892/mmr.2020.11343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32945458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32945458"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hwan Kim, Hyejin Oh, Young Soo Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-019-0284-5"}], "href": "https://doi.org/10.1038/s12276-019-0284-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31358736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31358736"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marcos J Magalhães-Junior, Maria Cristina Baracat-Pereira, Lorena K J Pereira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic and phosphoproteomic analyses reveal several events involved in the early stages of bovine herpesvirus 1 infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00705-019-04452-1"}], "href": "https://doi.org/10.1007/s00705-019-04452-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31705208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31705208"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Joakim Bastrup, Kathrine H Hansen, Thomas B G Poulsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-200715"}], "href": "https://doi.org/10.3233/JAD-200715"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33252074"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33252074"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Alfonso Bolado-Carrancio, Martin Lee, Ailith Ewing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02017-8"}], "href": "https://doi.org/10.1038/s41388-021-02017-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34556814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34556814"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tineke Kardol-Hoefnagel, Sofie A L M van Logtestijn, Henny G Otten "}, {"type": "b", "children": [{"type": "t", "text": "A Review on the Function and Regulation of ARHGDIB/RhoGDI2 Expression Including the Hypothetical Role of ARHGDIB/RhoGDI2 Autoantibodies in Kidney Transplantation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transplant Direct (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/TXD.0000000000000993"}], "href": "https://doi.org/10.1097/TXD.0000000000000993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32548242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32548242"}]}]}]}
Synonyms	RABGDIB, HEL-S-46E
Proteins	GDIB_HUMAN
NCBI Gene ID	2665
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GDI2 has 8,469 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for GDI2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GDI2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GDI2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GDI2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GDI2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GDI2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GDI2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GDI2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GDI2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GDI2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GDI2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GDI2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GDI2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GDI2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GDI2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GDI2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GDI2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GDI2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GDI2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GDI2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GDI2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GDI2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GDI2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GDI2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GDI2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GDI2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with GDI2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with GDI2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GDI2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GDI2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GDI2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GDI2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GDI2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GDI2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GDI2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GDI2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with GDI2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of GDI2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with GDI2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing GDI2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of GDI2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of GDI2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.