GGA1 Gene

Name	golgi-associated, gamma adaptin ear containing, ARF binding protein 1
Description	This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n GGA1 is a multifunctional adaptor protein primarily localized at the trans‐Golgi network (TGN) where it plays a central role in cargo selection and vesicular trafficking. Its modular structure—with an amino‐terminal VHS domain that directly recognizes acidic cluster–dileucine (ACLL)– or DXXLL‐based sorting signals in the cytosolic tails of cargo proteins, and a carboxy‐terminal GAT domain that mediates interactions with activated ARF1, rabaptin‑5, and other components of the coat machinery—underpins its essential function in directing proteins from the TGN into clathrin‐coated carriers destined for endosomes and lysosomes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " \n In addition, GGA1 directly binds to the sorting motifs of key membrane proteins – for example, the β‑site APP‐cleaving enzyme (BACE1) and memapsin 2 – thereby regulating their intracellular localization and processing. Through its interaction with these cargos, GGA1 mediates retrograde transport from endosomes to the TGN; such trafficking control is critical for determining the amyloidogenic processing of the amyloid precursor protein (APP), with implications for Alzheimer’s disease pathology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond modulating BACE1 sorting and APP processing, GGA1 also contributes to diverse trafficking events. It is involved in the targeted delivery of the polycystin complex to the ciliary compartment via a Rabep1/GGA1/Arl3–dependent mechanism, in the endocytic and secretory sorting of the stabilin‑1 receptor in macrophages, and in facilitating adiponectin secretion in adipocytes—each process relying on its capacity to recognize specific sorting signals and to recruit clathrin and accessory proteins."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " \n Furthermore, studies indicate that modulation of GGA1 levels (and its regulated interactions) alters the subcellular distribution of BACE1, thereby affecting the production of amyloid‑β peptides in the brain. In conditions such as traumatic brain injury and Alzheimer’s disease, depletion or altered function of GGA1 correlates with mislocalization of BACE1 and enhanced amyloidogenic processing."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": " \n Finally, structural studies have provided molecular details of the GAT domain of GGA1—revealing an elongated helical bundle that binds ARF1 and rabaptin‑5—which further clarifies its role in orchestrating coat assembly and cargo recognition at the TGN."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, GGA1 functions as a critical mediator of intracellular protein sorting by interpreting specific cytosolic sorting signals and recruiting the necessary vesicle‐coating machinery. Its actions ensure proper cargo delivery between the TGN, endosomes, lysosomes, and even to specialized compartments such as the cilium, thereby impacting key cellular processes including proteolytic processing events in neurodegeneration and regulated secretion in metabolic tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rafael Mattera, Cecilia N Arighi, Robert Lodge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg015"}], "href": "https://doi.org/10.1093/emboj/cdg015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12505986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12505986"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tomoo Shiba, Hiroyuki Takatsu, Terukazu Nogi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/415937a"}], "href": "https://doi.org/10.1038/415937a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11859376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11859376"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tina Wahle, Kai Prager, Nikolai Raffler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2005.03.014"}], "href": "https://doi.org/10.1016/j.mcn.2005.03.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15886016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15886016"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tomoo Shiba, Masato Kawasaki, Hiroyuki Takatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsb920"}], "href": "https://doi.org/10.1038/nsb920"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12679809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12679809"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiangyuan He, Wan-Pin Chang, Gerald Koelsch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03052-1"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03052-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12135764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12135764"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christine A F von Arnim, Michelle M Tangredi, Ithan D Peltan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01422"}], "href": "https://doi.org/10.1242/jcs.01422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15466887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15466887"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yogikala Prabhu, Patricia V Burgos, Christina Schindler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-11-0944"}], "href": "https://doi.org/10.1091/mbc.E11-11-0944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22553349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22553349"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Linglin Xie, Daniel Boyle, Daniel Sanford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M511313200"}], "href": "https://doi.org/10.1074/jbc.M511313200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16407204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16407204"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Christine A F von Arnim, Robert Spoelgen, Ithan D Peltan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2290-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.2290-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17005855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17005855"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jeremy H Herskowitz, Katrin Offe, Aniruddha Deshpande, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-01-0014"}], "href": "https://doi.org/10.1091/mbc.E12-01-0014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22621900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22621900"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kendall R Walker, Eugene L Kang, Michael J Whalen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.5491-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.5491-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22836275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22836275"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei Hong Toh, Pei Zhi Cheryl Chia, Mohammed Iqbal Hossain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E17-05-0270"}], "href": "https://doi.org/10.1091/mbc.E17-05-0270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29142073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29142073"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Claudia Santosa, Stefanie Rasche, Adel Barakat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2011.03.009"}], "href": "https://doi.org/10.1016/j.nbd.2011.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21440067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21440067"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Silke Suer, Saurav Misra, Layla F Saidi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0831133100"}], "href": "https://doi.org/10.1073/pnas.0831133100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12668765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12668765"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Francisco J del Castillo, Martine Cohen-Salmon, Anne Charollais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp490"}], "href": "https://doi.org/10.1093/hmg/ddp490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19864490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19864490"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "A G Rodriguez-Gabin, X Yin, Q Si, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2009.03.020"}], "href": "https://doi.org/10.1016/j.yexcr.2009.03.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19345684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19345684"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Hongdong Bai, Balraj Doray, Stuart Kornfeld "}, {"type": "b", "children": [{"type": "t", "text": "GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401158200"}], "href": "https://doi.org/10.1074/jbc.M401158200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14973137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14973137"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Tina Wahle, Dietmar R Thal, Magdalena Sastre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1982-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.1982-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17151287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17151287"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sang-Ho Kwon, Sekyung Oh, Marisa Nacke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.729202"}], "href": "https://doi.org/10.1074/jbc.M116.729202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27765817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27765817"}]}]}]}
Proteins	GGA1_HUMAN
NCBI Gene ID	26088
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GGA1 has 6,449 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 123 datasets.

Click the + buttons to view associations for GGA1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GGA1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GGA1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GGA1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GGA1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GGA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GGA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GGA1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GGA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GGA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GGA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GGA1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GGA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GGA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GGA1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with GGA1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GGA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GGA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GGA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing GGA1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GGA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GGA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing GGA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing GGA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing GGA1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GGA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GGA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GGA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GGA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with GGA1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of GGA1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GGA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with GGA1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GGA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GGA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GGA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GGA1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GGA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GGA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GGA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of GGA1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with GGA1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.