|HGNC Family||Gamma-glutamyltransferases (GGT)|
|Name||gamma-glutamyltransferase light chain 3|
|Description||Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]|
|NCBI Gene ID||728226|
|Expression in Tissues and Cell Lines||
GGTLC3 has 82 functional associations with biological entities spanning 2 categories (functional term, phrase or reference, cell line, cell type or tissue) extracted from 7 datasets.
Click the + buttons to view associations for GGTLC3 from the datasets below.
If available, associations are ranked by standardized value
|COMPARTMENTS Curated Protein Localization Evidence Scores||cellular components containing GGTLC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.|
|GeneSigDB Published Gene Signatures||PubMedIDs of publications reporting gene signatures containing GGTLC3 from the GeneSigDB Published Gene Signatures dataset.|
|GTEx Tissue Gene Expression Profiles||tissues with high or low expression of GGTLC3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.|
|HPA Cell Line Gene Expression Profiles||cell lines with high or low expression of GGTLC3 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.|
|HPA Tissue Gene Expression Profiles||tissues with high or low expression of GGTLC3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.|
|HPA Tissue Sample Gene Expression Profiles||tissue samples with high or low expression of GGTLC3 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.|
|TISSUES Experimental Tissue Protein Expression Evidence Scores||tissues with high expression of GGTLC3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.|