{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n This combined abstract summarizes two distinct contexts in which “GHDC” is discussed in the recent literature.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In one set of studies, GHDC is referenced as a candidate gene identified in domestic animal models. Genome‐wide analyses in dairy cattle have implicated GHDC among several loci associated with milk production traits; notably, this gene is highly differentially expressed in the mammary gland compared with a panel of other tissues, suggesting a specialized role in lactation biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, functional mutations in the transcription units of GHDC have been identified in rabbit lines, with such mutations being fixed in one line and absent in the other, which highlights its potential relevance in metabolic or developmental processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, copy number changes encompassing GHDC have been documented in a patient with developmental delay and dysmorphic features, further implying that variations in its dosage might contribute to phenotypic variability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In another context, GHDC stands for “growth hormone day curve” and represents an integrated diagnostic tool used in the assessment of acromegaly. In these studies, serial measurements of growth hormone (GH) over the course of a day (the GHDC) were employed to evaluate biochemical control and therapeutic end‐points in patients with acromegaly. The GHDC parameters show strong correlations with oral glucose tolerance test (OGTT) results and circulating IGF-I levels, thereby providing a practical, cost‐effective alternative to more cumbersome sampling protocols for postoperative evaluation and therapy monitoring."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, the literature highlights the multifaceted nature of “GHDC”: as a candidate gene its differential expression and mutational status may influence lactation and developmental processes in animal models, while as a growth hormone day curve it serves as a robust clinical parameter to assess disease status and treatment efficacy in acromegaly.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lesley-Ann Raven, Benjamin G Cocks, Kathryn E Kemper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mamm Genome (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00335-015-9613-8"}], "href": "https://doi.org/10.1007/s00335-015-9613-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26613780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26613780"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cristina Casto-Rebollo, María José Argente, María Luz García, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Sel Evol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12711-021-00653-y"}], "href": "https://doi.org/10.1186/s12711-021-00653-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34256696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34256696"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Céline Poirsier-Violle, Azzedine Abourra, Clarisse Baumann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A de novo 17q21.2 duplication in a boy with developmental delay and dysmorphic features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2012.12.005"}], "href": "https://doi.org/10.1016/j.ejmg.2012.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23337768"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23337768"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Francesco M Minuto, Eugenia Resmini, Mara Boschetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical diagnosis and assessment of disease activity in acromegaly: a two-decade experience."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pituitary (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11102-011-0313-4"}], "href": "https://doi.org/10.1007/s11102-011-0313-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21544532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21544532"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "N Karavitaki, A Fernandez, V Fazal-Sanderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The value of the oral glucose tolerance test, random serum growth hormone and mean growth hormone levels in assessing the postoperative outcome of patients with acromegaly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Endocrinol (Oxf) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2265.2009.03578.x"}], "href": "https://doi.org/10.1111/j.1365-2265.2009.03578.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19320648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19320648"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Niki Karavitaki, Ileana Botusan, Serban Radian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The value of an acute octreotide suppression test in predicting long-term responses to depot somatostatin analogues in patients with active acromegaly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Endocrinol (Oxf) (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2265.2004.02191.x"}], "href": "https://doi.org/10.1111/j.1365-2265.2004.02191.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15730408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15730408"}]}]}]}