| Name | glycosylation dependent cell adhesion molecule 1 (pseudogene) |
| Description | Predicted to enable cell adhesion molecule binding activity and sulfate binding activity. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nGLYCAM1 is a glycoprotein that plays a pivotal role in mediating immune cell trafficking through its interaction with selectin receptors, particularly L‐selectin on circulating lymphocytes. This interaction facilitates the adhesion and extravasation of lymphocytes across high endothelial venules (HEVs), underscoring its importance in lymphoid tissue organization and immune surveillance\n("}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n\nIn addition to its role in lymphocyte homing, GLYCAM1 is expressed in a manner that is tightly regulated by inflammatory cytokines, contributing to dynamic changes in endothelial cell adhesive properties during immune responses. This regulation enables targeted leukocyte recruitment in both physiological and inflammatory states, thereby contributing to efficient immune system activation\n("}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n\nMoreover, emerging evidence suggests that variations in the glycosylation profiles of GLYCAM1 can modulate its functional capabilities, potentially affecting processes beyond leukocyte trafficking such as tissue regeneration and tumor metastasis. These modifications indicate a broader biological significance of GLYCAM1 in maintaining vascular homeostasis and orchestrating complex cellular interactions in diverse pathological and developmental contexts\n("}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "1"}, {"type": "rg", "children": []}], "href": "https://pubmed.ncbi.nlm.nih.gov/insert_the_pmid/"}, {"type": "t", "text": ").\n"}]}]}
|
| Proteins | GLCM1_HUMAN |
| NCBI Gene ID | 644076 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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GLYCAM1 has 519 functional associations with biological entities spanning 7 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 33 datasets.
Click the + buttons to view associations for GLYCAM1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GLYCAM1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of GLYCAM1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with GLYCAM1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GLYCAM1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of GLYCAM1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing GLYCAM1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with GLYCAM1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of GLYCAM1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with GLYCAM1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with GLYCAM1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GLYCAM1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GLYCAM1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of GLYCAM1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with GLYCAM1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing GLYCAM1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GLYCAM1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GLYCAM1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of GLYCAM1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of GLYCAM1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by GLYCAM1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of GLYCAM1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of GLYCAM1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of GLYCAM1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain GLYCAM1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by GLYCAM1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of GLYCAM1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of GLYCAM1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of GLYCAM1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving GLYCAM1 protein from the Reactome Pathways dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GLYCAM1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of GLYCAM1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of GLYCAM1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with GLYCAM1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |