{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies primarily focuses on elucidating the metabolic and mitochondrial dysfunctions underlying propionic acidemia (PA) as well as exploring therapeutic interventions, including gene therapy and metabolic modulation. Importantly, none of these abstracts report any findings or insights regarding GOLGA8DP. Its function, expression, or potential involvement in PA‐related pathways is not addressed, suggesting that its role (if any) remains to be characterized in future work."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOne study examines bioenergetic disturbances in a PA mouse model, highlighting reduced mitochondrial oxidative phosphorylation activity, mtDNA depletion, and altered antioxidant responses, along with compensatory increases in mitochondrial markers in the brain. Despite these detailed analyses of mitochondrial dysfunction and oxidative stress, no mention is made of GOLGA8DP or any related golgin family protein in the pathological context of PA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA separate investigation evaluates the metabolic effects of fasting in a PA model, reporting decreases in biomarkers such as propionylcarnitine and methylcitrate, along with enhanced fatty acid oxidation and gluconeogenesis. This study, like the others, centers on metabolic adaptations and does not provide any data on GOLGA8DP’s function. Overall, while the studies contribute significantly to understanding the biochemical and therapeutic aspects of PA, the function of GOLGA8DP remains undetermined within these contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adam J Guenzel, Renata Collard, Jan P Kraus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2014.126"}], "href": "https://doi.org/10.1089/hum.2014.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25654275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25654275"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Gallego-Villar, A Rivera-Barahona, C Cuevas-Martín, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2016.04.007"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2016.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27083476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27083476"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wentao He, Hannah Marchuk, Dwight Koeberl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-024-06362-8"}], "href": "https://doi.org/10.1038/s42003-024-06362-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38811689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38811689"}]}]}]}