Name | golgin A8 family, member D, pseudogene |
Description | Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of studies primarily focuses on elucidating the metabolic and mitochondrial dysfunctions underlying propionic acidemia (PA) as well as exploring therapeutic interventions, including gene therapy and metabolic modulation. Importantly, none of these abstracts report any findings or insights regarding GOLGA8DP. Its function, expression, or potential involvement in PA‐related pathways is not addressed, suggesting that its role (if any) remains to be characterized in future work."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOne study examines bioenergetic disturbances in a PA mouse model, highlighting reduced mitochondrial oxidative phosphorylation activity, mtDNA depletion, and altered antioxidant responses, along with compensatory increases in mitochondrial markers in the brain. Despite these detailed analyses of mitochondrial dysfunction and oxidative stress, no mention is made of GOLGA8DP or any related golgin family protein in the pathological context of PA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA separate investigation evaluates the metabolic effects of fasting in a PA model, reporting decreases in biomarkers such as propionylcarnitine and methylcitrate, along with enhanced fatty acid oxidation and gluconeogenesis. This study, like the others, centers on metabolic adaptations and does not provide any data on GOLGA8DP’s function. Overall, while the studies contribute significantly to understanding the biochemical and therapeutic aspects of PA, the function of GOLGA8DP remains undetermined within these contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adam J Guenzel, Renata Collard, Jan P Kraus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-term sex-biased correction of circulating propionic acidemia disease markers by adeno-associated virus vectors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2014.126"}], "href": "https://doi.org/10.1089/hum.2014.126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25654275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25654275"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Gallego-Villar, A Rivera-Barahona, C Cuevas-Martín, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2016.04.007"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2016.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27083476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27083476"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wentao He, Hannah Marchuk, Dwight Koeberl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-024-06362-8"}], "href": "https://doi.org/10.1038/s42003-024-06362-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38811689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38811689"}]}]}]}
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Synonyms | GOLGA8D |
Proteins | GOG8D_HUMAN |
NCBI Gene ID | 100132979 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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GOLGA8DP has 397 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 19 datasets.
Click the + buttons to view associations for GOLGA8DP from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of GOLGA8DP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GOLGA8DP gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of GOLGA8DP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing GOLGA8DP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of GOLGA8DP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GOLGA8DP gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of GOLGA8DP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing GOLGA8DP from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GOLGA8DP gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of GOLGA8DP gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GO Biological Process Annotations 2023 | biological processes involving GOLGA8DP gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing GOLGA8DP protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of GOLGA8DP gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of GOLGA8DP gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of GOLGA8DP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of GOLGA8DP gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of GOLGA8DP gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of GOLGA8DP protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of GOLGA8DP protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |