{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided studies reveals a broad investigation into proteins and pathways central to neurodegenerative disorders, cytoskeletal regulation, and cellular signaling. Several reports focus on neurodegeneration in late‐infantile neuronal ceroid lipofuscinosis (LINCL), demonstrating that mutations in the CLN2 gene lead to a deficiency in the lysosomal protease tripeptidyl‐peptidase I (TPP‐I), with consequent neuronal storage defects and premature cell loss (for example."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": " Other studies delineate the role of microtubule (MT) plus end‐tracking proteins—including the well‐characterized CLIP‐170—in modulating MT dynamics, which is essential for processes such as axonal guidance, cell migration, and synaptic function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "16"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary work has addressed regulatory molecules—such as WBP2 and AMPK—and their interplay with oncogenic pathways as well as with neurodevelopment and metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": " Despite the substantial insights these studies provide into lysosomal function, MT dynamics, and associated signaling pathways, none of the reports offer data or discussion regarding the gene GOLGA8Q. Therefore, while the collective literature advances our understanding of enzymes such as TPP‐I and regulators like CLIP‐170 in health and disease, the specific cellular function of GOLGA8Q remains uncharacterized and warrants targeted future research.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David E Sleat, Jennifer A Wiseman, Mukarram El-Banna, et al. 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