HGNC Family | G protein-coupled receptors |
Name | G protein-coupled receptor 35 |
Description | Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n G protein‐coupled receptor 35 (GPR35) has emerged as a multifunctional receptor that integrates diverse extracellular signals to regulate metabolic, immune, cardiovascular, and neural functions. Endogenous ligands including kynurenic acid have been shown to activate GPR35 in adipose tissue, thereby stimulating lipid metabolism, thermogenic and anti‐inflammatory gene expression that improves energy utilization and glucose tolerance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Genetic studies have further implicated GPR35 in gastrointestinal inflammatory disorders: specific missense variants are associated with increased susceptibility to primary sclerosing cholangitis and inflammatory bowel disease (IBD) including ulcerative colitis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, GPR35 has been identified as the receptor for the mucosal chemokine CXCL17, suggesting a chemotactic role in mucosal innate immunity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while 2‐acyl lysophosphatidic acid, another endogenous mediator, signals via GPR35 to trigger sustained Ca<sup>2+</sup> mobilization and ERK1/2 phosphorylation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In invariant natural killer T cells, receptor activation attenuates the release of interleukin‐4 via Gi/o–protein–dependent mechanisms"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and additional pharmacological studies have characterized species‐selective agonists and coupling to Gα13."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the cardiovascular system, hypoxia‐induced upregulation of GPR35 in cardiomyocytes appears to mediate cytoskeletal alterations and may serve as an early marker of cardiac stress and failure"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", while receptor deficiency or pharmacological modulation alters blood pressure responses and vascular remodeling through effects on smooth muscle and endothelial cell migration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n GPR35 also contributes to innate immune cell recruitment; activated neutrophils upregulate GPR35 and respond to platelet‐derived 5‐hydroxyindoleacetic acid to facilitate transmigration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In the nervous system, receptor expression in rat sympathetic neurons tonically inhibits N‐type Ca<sup>2+</sup> channels and modulates synaptic transmission"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", and in cultured astrocytes, GPR35 activation modulates cAMP production and the plateau phase of intracellular Ca<sup>2+</sup> fluxes, potentially contributing to decreases in extracellular glutamate levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In disease contexts, loss or altered signaling of GPR35 affects tissue homeostasis; for example, its deficiency is linked to worsened experimental colitis, impaired epithelial goblet cell function, and dysbiosis in the intestine"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", while in tumors, increased GPR35 expression correlates with higher proliferation and migration in breast and colon cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, selective agonists such as zaprinast and pamoic acid have demonstrated antinociceptive and neuroprotective properties in rodent models of stroke, highlighting the therapeutic potential of targeting GPR35 in pain and cardiovascular pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that GPR35 functions as a critical metabolic and immunomodulatory receptor whose diverse ligand interactions influence energy homeostasis, inflammatory responses, cardiovascular dynamics, neuronal excitability, and tumorigenesis, thereby representing a promising target for therapeutic intervention (1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leandro Z Agudelo, Duarte M S Ferreira, Igor Cervenka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2018.01.004"}], "href": "https://doi.org/10.1016/j.cmet.2018.01.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29414686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29414686"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "David Ellinghaus, Trine Folseraas, Kristian Holm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.25977"}], "href": "https://doi.org/10.1002/hep.25977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22821403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22821403"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zheng Yansen, Zhuo Lingang, Li Dali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inflammatory bowel disease susceptible gene GPR35 promotes bowel inflammation in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yi Chuan (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.16288/j.yczz.20-392"}], "href": "https://doi.org/10.16288/j.yczz.20-392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33724219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33724219"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "José L Maravillas-Montero, Amanda M Burkhardt, Peter A Hevezi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1401704"}], "href": "https://doi.org/10.4049/jimmunol.1401704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25411203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25411203"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Saori Oka, Ryo Ota, Mitsuru Shima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPR35 is a novel lysophosphatidic acid receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.03.169"}], "href": "https://doi.org/10.1016/j.bbrc.2010.03.169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20361937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20361937"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Silvia Fallarini, Laura Magliulo, Tiziana Paoletti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of functional GPR35 in human iNKT cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.06.091"}], "href": "https://doi.org/10.1016/j.bbrc.2010.06.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20599711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20599711"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laura Jenkins, Jose Brea, Nicola J Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20101287"}], "href": "https://doi.org/10.1042/BJ20101287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20919992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20919992"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Veli-Pekka Ronkainen, Tomi Tuomainen, Jenni Huusko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvt226"}], "href": "https://doi.org/10.1093/cvr/cvt226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24095869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24095869"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Shukkur M Farooq, Yuning Hou, Hainan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-018-5216-z"}], "href": "https://doi.org/10.1007/s10620-018-5216-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30043283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30043283"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jennifer E McCallum, Amanda E Mackenzie, Nina Divorty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Vasc Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000444754"}], "href": "https://doi.org/10.1159/000444754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27064272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27064272"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Marco De Giovanni, Hanson Tam, Colin Valet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2022.01.010"}], "href": "https://doi.org/10.1016/j.cell.2022.01.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35148838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35148838"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Juan Guo, Damian J Williams, Henry L Puhl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharmacol Exp Ther (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/jpet.107.127266"}], "href": "https://doi.org/10.1124/jpet.107.127266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17940199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17940199"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rolando Berlinguer-Palmini, Alessio Masi, Roberto Narducci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0082180"}], "href": "https://doi.org/10.1371/journal.pone.0082180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24312407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24312407"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hassan Melhem, Berna Kaya, Tanay Kaymak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mucosal Immunol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41385-022-00494-y"}], "href": "https://doi.org/10.1038/s41385-022-00494-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35264769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35264769"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ya Jie Guo, Yu Jie Zhou, Xiao Li Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.09.113"}], "href": "https://doi.org/10.1016/j.bbrc.2017.09.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28943434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28943434"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Haytham Ali, Manar AbdelMageed, Lina Olsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Utility of G protein-coupled receptor 35 expression for predicting outcome in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428319858885"}], "href": "https://doi.org/10.1177/1010428319858885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31250711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31250711"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ozayra Sharmin, Ariful Haque Abir, Abdullah Potol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-66417-8"}], "href": "https://doi.org/10.1038/s41598-020-66417-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32523084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32523084"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Nina Divorty, Graeme Milligan, Delyth Graham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hypertens (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ajh/hpy073"}], "href": "https://doi.org/10.1093/ajh/hpy073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29860395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29860395"}]}]}]}
|
Proteins | GPR35_HUMAN |
NCBI Gene ID | 2859 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
GPR35 has 4,456 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 103 datasets.
Click the + buttons to view associations for GPR35 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by GPR35 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of GPR35 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of GPR35 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of GPR35 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of GPR35 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of GPR35 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GPR35 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GPR35 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPR35 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with GPR35 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GPR35 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of GPR35 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of GPR35 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GPR35 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing GPR35 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing GPR35 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with GPR35 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with GPR35 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPR35 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with GPR35 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with GPR35 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with GPR35 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by GPR35 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with GPR35 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with GPR35 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with GPR35 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with GPR35 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with GPR35 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with GPR35 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GPR35 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of GPR35 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of GPR35 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing GPR35 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with GPR35 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with GPR35 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with GPR35 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing GPR35 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of GPR35 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving GPR35 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving GPR35 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving GPR35 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing GPR35 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by GPR35 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by GPR35 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by GPR35 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of GPR35 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of GPR35 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of GPR35 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of GPR35 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding GPR35 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
GWAS Catalog SNP-Phenotype Associations | phenotypes associated with GPR35 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset. | |
GWASdb SNP-Disease Associations | diseases associated with GPR35 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with GPR35 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of GPR35 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of GPR35 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with GPR35 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by GPR35 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for GPR35 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of GPR35 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving GPR35 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of GPR35 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of GPR35 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with GPR35 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of GPR35 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of GPR35 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain GPR35 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by GPR35 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of GPR35 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for GPR35 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of GPR35 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of GPR35 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of GPR35 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of GPR35 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving GPR35 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving GPR35 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2024 | pathways involving GPR35 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of GPR35 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of GPR35 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at GPR35 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of GPR35 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of GPR35 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with GPR35 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of GPR35 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of GPR35 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of GPR35 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of GPR35 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of GPR35 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of GPR35 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of GPR35 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with GPR35 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with GPR35 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving GPR35 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving GPR35 protein from the WikiPathways Pathways 2024 dataset. | |