GRK6 Gene

Name	G protein-coupled receptor kinase 6
Description	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n G protein–coupled receptor kinase 6 (GRK6) emerges as a multifaceted regulator of G protein–coupled receptor (GPCR) signaling across diverse systems. In immune cells, GRK6 phosphorylates key receptors such as CXCR4, thereby controlling receptor desensitization, recycling, and chemotactic responses. For example, GRK6‐dependent phosphorylation of CXCR4 at distinct serine residues is critical for proper lymphocyte chemotaxis, neutrophil mobilization, and even dendritic cell haptotaxis, ensuring directional migration in established chemokine gradients."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In cardiac stem cells, GRK6 phosphorylates CXCR4 (e.g., at Ser339), facilitating stem cell migration in response to stem cell factor signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In mast cells, GRK6 modulates receptor signaling by influencing C3a receptor–mediated degranulation and downstream extracellular signal–regulated kinase (ERK) activation, thereby affecting inflammatory mediator release."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, GRK6 is essential for optimal signaling by endocrine receptors; it not only supports β‐arrestin–dependent ERK activation downstream of the follicle‐stimulating hormone receptor"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "but also governs oxytocin receptor desensitization in myometrial cells, a process that is crucial for normal uterine contractility during labor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the central nervous system, GRK6 modulates dopaminergic transmission by desensitizing D2‐like receptors; its deficiency results in enhanced receptor coupling and postsynaptic supersensitivity to psychostimulants, contributing to behavioral alterations."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In neurodegenerative contexts, aberrant GRK6 activity drives the phosphorylation of α‐synuclein at specific residues, thereby exacerbating neurotoxicity in Parkinson disease models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n GRK6’s role also extends to cancer biology. In multiple myeloma, for instance, inhibition of GRK6 decreases STAT3 phosphorylation and MCL1 levels, revealing a selective vulnerability that may be exploited therapeutically."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Conversely, overexpression of GRK6 in hepatocellular carcinoma is associated with increased proliferation, metastasis, and poorer clinical outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional investigations have implicated GRK6 in the regulation of other GPCRs. It contributes to the desensitization of the M<sub>3</sub> muscarinic receptor in neuronal cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and participates in corticotropin releasing factor receptor signaling through modulation of β‐arrestin recruitment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Furthermore, GRK6 forms complexes with signaling proteins (e.g., with AGS3 and Gαi2 to regulate CXCR2 signaling) that influence leukocyte activation and receptor trafficking"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", while mediating the phosphorylation events required for proper receptor internalization in macrophages expressing the chemerin receptor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore the central role of GRK6 as a regulator of receptor phosphorylation, desensitization, and downstream effector signaling across a spectrum of physiological systems—including immune regulation, neurophysiology, reproductive biology, and oncogenesis. Its diverse actions highlight the therapeutic potential of targeting GRK6 in various disease states.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alan M Fong, Richard T Premont, Ricardo M Richardson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.112198299"}], "href": "https://doi.org/10.1073/pnas.112198299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12032308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12032308"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "John M Busillo, Sylvain Armando, Rajarshi Sengupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.091173"}], "href": "https://doi.org/10.1074/jbc.M109.091173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20048153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20048153"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anne Vroon, Cobi J Heijnen, Roel Raatgever, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0703320"}], "href": "https://doi.org/10.1189/jlb.0703320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14704365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14704365"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jan Schwarz, Veronika Bierbaum, Kari Vaahtomeri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2017.04.004"}], "href": "https://doi.org/10.1016/j.cub.2017.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28457871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28457871"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ke Zuo, Dong Kuang, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SCF/c-kit transactivates CXCR4-serine 339 phosphorylation through G protein-coupled receptor kinase 6 and regulates cardiac stem cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26812"}], "href": "https://doi.org/10.1038/srep26812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27245949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27245949"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qiang Guo, Hariharan Subramanian, Kshitij Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0022559"}], "href": "https://doi.org/10.1371/journal.pone.0022559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21799898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21799898"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Elodie Kara, Pascale Crépieux, Christophe Gauthier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2006-0098"}], "href": "https://doi.org/10.1210/me.2006-0098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16887887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16887887"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jonathon M Willets, Paul J Brighton, Rajendra Mistry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2009-0047"}], "href": "https://doi.org/10.1210/me.2009-0047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19423652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19423652"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chad A Grotegut, Lan Mao, Stephanie L Pierce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2015-1147"}], "href": "https://doi.org/10.1210/me.2015-1147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26886170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26886170"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Raul R Gainetdinov, Laura M Bohn, Tatyana D Sotnikova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(03)00192-2"}], "href": "https://doi.org/10.1016/s0896-6273(03"}, {"type": "t", "text": "00192-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12718862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12718862"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hiroyasu Sato, Shigeki Arawaka, Susumu Hara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3967-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.3967-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22090514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22090514"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rodger E Tiedemann, Yuan Xiao Zhu, Jessica Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-09-243980"}], "href": "https://doi.org/10.1182/blood-2009-09-243980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19996089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19996089"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ya-Ping Li "}, {"type": "b", "children": [{"type": "t", "text": "GRK6 expression in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Trop Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S1995-7645(13)60027-9"}], "href": "https://doi.org/10.1016/S1995-7645(13"}, {"type": "t", "text": "60027-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23375037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23375037"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jonathon M Willets, R A John Challiss, Stefan R Nahorski "}, {"type": "b", "children": [{"type": "t", "text": "Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111217200"}], "href": "https://doi.org/10.1074/jbc.M111217200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11856737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11856737"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Thalia Teli, Danijela Markovic, Michael A Levine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2004-0275"}], "href": "https://doi.org/10.1210/me.2004-0275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15498832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15498832"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Vandana Singh, Sandeep K Raghuwanshi, Nikia Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1301875"}], "href": "https://doi.org/10.4049/jimmunol.1301875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24510965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24510965"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "D Stephen Serafin, Brittney Allyn, Maria F Sassano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2018.12.016"}], "href": "https://doi.org/10.1016/j.molimm.2018.12.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30576947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30576947"}]}]}]}
Synonyms	GPRK6
Proteins	GRK6_HUMAN
NCBI Gene ID	2870
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

GRK6 has 6,607 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 131 datasets.

Click the + buttons to view associations for GRK6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

GRK6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of GRK6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of GRK6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of GRK6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of GRK6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of GRK6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRK6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of GRK6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of GRK6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRK6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of GRK6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with GRK6 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with GRK6 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRK6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of GRK6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of GRK6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of GRK6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing GRK6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of GRK6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing GRK6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing GRK6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with GRK6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with GRK6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of GRK6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with GRK6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with GRK6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with GRK6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of GRK6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by GRK6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for GRK6 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with GRK6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with GRK6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with GRK6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with GRK6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with GRK6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at GRK6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of GRK6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of GRK6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing GRK6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.