HAS2 Gene

HGNC Family	Glycosyltransferases
Name	hyaluronan synthase 2
Description	Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Hyaluronan synthase 2 (HAS2) is a pivotal enzyme that catalyzes the synthesis of hyaluronan (HA), an essential extracellular matrix glycosaminoglycan involved in a wide spectrum of biological processes. During embryonic development, HAS2‐derived HA is critical for the formation of the cardiac jelly and for endocardial‐to‐mesenchymal transition, processes required for proper cardiac cushion and valve morphogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the ovary, HAS2 is instrumental in mediating cumulus expansion—a process essential for oocyte maturation and ovulation—by regulating the formation of a HA‐rich extracellular matrix within oocyte–granulosa cell complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pathophysiological settings, aberrant HAS2 expression underlies several disease processes. In the lung, overexpression of HAS2 by myofibroblasts leads to aggressive, invasive phenotypes that promote severe fibrosis, whereas conditional deletion in alveolar epithelial cells impairs tissue repair and accelerates fibrotic remodeling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In parallel, HAS2‐dependent HA production modulates fibroblast differentiation into myofibroblasts via CD44 clustering and downstream MAPK and CaMKII signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer, elevated HAS2 expression is associated with a more invasive and aggressive phenotype. Highly invasive breast cancer cells preferentially express HAS2, and its overexpression enhances tumor cell migration and invasion, in part by modulating ErbB2 phosphorylation and the dynamics of the pericellular HA matrix."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, HAS2 function is subjected to multifaceted layers of regulation. Post‐translational modifications such as O‐GlcNAcylation—which occurs on serine 221—enhance both HAS2 stability and enzymatic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " In addition, proper dimerization and ubiquitination of HAS2, including modification at lysine 190, are crucial for maintaining optimal HA synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": " Collectively, these studies establish HAS2 as a central mediator of HA synthesis that orchestrates cell–matrix interactions critical for normal development, tissue remodeling, wound healing, and tumor progression, making it an attractive target for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lijiang Ma, Mei-Fang Lu, Robert J Schwartz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02156"}], "href": "https://doi.org/10.1242/dev.02156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314491"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Todd D Camenisch, Joyce A Schroeder, Judy Bradley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm742"}], "href": "https://doi.org/10.1038/nm742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12134143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12134143"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "You-Qiang Su, Xuemei Wu, Marilyn J O'Brien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2004.08.020"}], "href": "https://doi.org/10.1016/j.ydbio.2004.08.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15531364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15531364"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Osamu Yoshino, Heather E McMahon, Shweta Sharma, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2002-220435"}], "href": "https://doi.org/10.1210/en.2002-220435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12586778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12586778"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "You-Qiang Su, James M Denegre, Karen Wigglesworth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0012-1606(03)00437-8"}], "href": "https://doi.org/10.1016/s0012-1606(03"}, {"type": "t", "text": "00437-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14568551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14568551"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jia Peng, Qinglei Li, Karen Wigglesworth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1218020110"}], "href": "https://doi.org/10.1073/pnas.1218020110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23382188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23382188"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuejuan Li, Dianhua Jiang, Jiurong Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20102510"}], "href": "https://doi.org/10.1084/jem.20102510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21708929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21708929"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jiurong Liang, Yanli Zhang, Ting Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4192"}], "href": "https://doi.org/10.1038/nm.4192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27694932"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27694932"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Adam C Midgley, Mathew Rogers, Maurice B Hallett, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.451336"}], "href": "https://doi.org/10.1074/jbc.M113.451336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23589287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23589287"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Shibnath Ghatak, Suniti Misra, Bryan P Toole "}, {"type": "b", "children": [{"type": "t", "text": "Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M410882200"}], "href": "https://doi.org/10.1074/jbc.M410882200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15632176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15632176"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yuejuan Li, Lingli Li, Tracey J Brown, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.22550"}], "href": "https://doi.org/10.1002/ijc.22550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17315194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17315194"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Naoki Itano, Takahiro Sawai, Fukiko Atsumi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.402347"}], "href": "https://doi.org/10.1074/jbc.M112.402347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22887999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22887999"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Davide Vigetti, Sara Deleonibus, Paola Moretto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.597401"}], "href": "https://doi.org/10.1074/jbc.M114.597401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25183006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25183006"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Eugenia Karousou, Masaru Kamiryo, Spyros S Skandalis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.127050"}], "href": "https://doi.org/10.1074/jbc.M110.127050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20507985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20507985"}]}]}]}
Proteins	HYAS2_HUMAN
NCBI Gene ID	3037
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HAS2 has 8,054 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 110 datasets.

Click the + buttons to view associations for HAS2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HAS2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HAS2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HAS2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HAS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HAS2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HAS2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HAS2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HAS2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HAS2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HAS2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HAS2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HAS2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HAS2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HAS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HAS2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HAS2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HAS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HAS2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HAS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HAS2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HAS2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HAS2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HAS2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HAS2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HAS2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with HAS2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HAS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HAS2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HAS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HAS2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HAS2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HAS2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HAS2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HAS2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HAS2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HAS2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HAS2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HAS2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HAS2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of HAS2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of HAS2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.