HAT1 Gene

HGNC Family	Chromatin-modifying enzymes
Name	histone acetyltransferase 1
Description	The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase that canonically acetylates newly synthesized histone H4 on lysines 5 and 12, thereby promoting replication‐coupled chromatin assembly and proper nucleosome formation. In this context, HAT1 facilitates the recruitment of bromodomain‐containing factors to nascent chromatin, ensuring robust replication fork progression and preserving chromatin topology and genome integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its well‐established role in chromatin assembly, HAT1 contributes to DNA repair by promoting homologous recombination; it facilitates the incorporation of acetylated histone variants at DNA double‐strand break sites, thereby enhancing the recruitment of repair factors such as RAD51."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n HAT1 also functions as a metabolic sensor that couples histone production with nutrient and energy status. Its expression and activity are modulated by AMPK signaling and coordinate glucose metabolism with the transcriptional regulation of proliferation‐associated genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, beyond acetylation, HAT1 exhibits non‐canonical succinyltransferase activity; it catalyzes the succinylation of histones and non‐histone proteins, thus contributing to epigenetic regulation and fostering tumorigenic processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Aberrant HAT1 expression is observed in a variety of human cancers. Elevated HAT1 levels have been linked to enhanced tumor cell proliferation, reduced apoptosis, chemoresistance, and altered immune regulation. In pancreatic cancer, for instance, HAT1 drives PD-L1 transcription through a BRD4-dependent mechanism and promotes gemcitabine resistance by modulating the PVT1/EZH2 complex; similarly, overexpression of HAT1 has been reported in hepatocellular, esophageal, nasopharyngeal cancers as well as in osteosarcoma, where it influences oncogenic signaling pathways including Wnt signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n HAT1 further modulates inflammatory responses by acetylating transcription regulators such as PLZF, which in turn assemble repressor complexes to restrain NF-κB–mediated cytokine production"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", and contributes to centromere function by ensuring proper H4 acetylation needed for CENP-A deposition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Regulation of HAT1 itself occurs at both transcriptional and post-transcriptional levels. MicroRNAs such as miR-486 and miR-377 have been shown to target HAT1 mRNA, thereby modulating pathways involved in cholesterol homeostasis and cell survival, respectively."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Structural and biochemical dissection of the Hat1/Hat2 complex has provided detailed insights into its substrate specificity and the interdependency of acetylation events on histone H4, offering a mechanistic framework for how site-specific acetylation can regulate subsequent histone modifications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In line with its multifaceted roles, global proteomic profiling has expanded the known repertoire of HAT1 substrates, further underscoring its broad impact on cellular acetylome regulation and signal transduction pathways in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, conditional knockout models and shRNA-mediated depletion studies demonstrate that loss of HAT1 impairs cell-cycle progression, diminishes colony formation, and reduces lifespan, thereby highlighting its critical role in chromatin replication, genome stability, and overall cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paula A Agudelo Garcia, Michael E Hoover, Pei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of multiple roles for histone acetyltransferase 1 in replication-coupled chromatin assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx545"}], "href": "https://doi.org/10.1093/nar/gkx545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28666361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28666361"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paula A Agudelo Garcia, Callie M Lovejoy, Prabakaran Nagarajan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetyltransferase 1 is required for DNA replication fork function and stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.013496"}], "href": "https://doi.org/10.1074/jbc.RA120.013496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32366460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32366460"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hui Zhang, Junhong Han, Bin Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.312637"}], "href": "https://doi.org/10.1074/jbc.M111.312637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22228774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22228774"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaohan Yang, Lei Li, Jing Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.473199"}], "href": "https://doi.org/10.1074/jbc.M113.473199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23653357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23653357"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Joshua J Gruber, Benjamin Geller, Andrew M Lipchik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2019.05.034"}], "href": "https://doi.org/10.1016/j.molcel.2019.05.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31278053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31278053"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Traci L Marin, Brendan Gongol, Fan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aaf7478"}], "href": "https://doi.org/10.1126/scisignal.aaf7478"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28143904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28143904"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Guang Yang, Ying Yuan, Hongfeng Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.202050967"}], "href": "https://doi.org/10.15252/embr.202050967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33372411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33372411"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ping Fan, Jingyuan Zhao, Zibo Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1044-z"}], "href": "https://doi.org/10.1186/s13046-019-1044-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30709380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30709380"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yan Sun, Dianyun Ren, Yingke Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04118-4"}], "href": "https://doi.org/10.1038/s41419-021-04118-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34564701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34564701"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xin Jin, Shenghua Tian, Pingping Li "}, {"type": "b", "children": [{"type": "t", "text": "Histone Acetyltransferase 1 Promotes Cell Proliferation and Induces Cisplatin Resistance in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504016X14809827856524"}], "href": "https://doi.org/10.3727/096504016X14809827856524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27938492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27938492"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Liang Xue, Jun Hou, Qun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNAi screening identifies HAT1 as a potential drug target in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25120766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25120766"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Bei-Ping Miao, Rui-Shi Zhang, Gui Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2018.03.040"}], "href": "https://doi.org/10.1016/j.abb.2018.03.040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29621521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29621521"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peng Xia, Rui Gu, Wei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-377 exerts a potent suppressive role in osteosarcoma through the involvement of the histone acetyltransferase 1-mediated Wnt axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28843"}], "href": "https://doi.org/10.1002/jcp.28843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31152456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31152456"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anthony J Sadler, Bandar A Suliman, Liang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7795"}], "href": "https://doi.org/10.1038/ncomms7795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25865065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25865065"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei-Hao Shang, Tetsuya Hori, Frederick G Westhorpe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms13465"}], "href": "https://doi.org/10.1038/ncomms13465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27811920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27811920"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dan Liu, Min Zhang, Wei Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-486 regulates cholesterol efflux by targeting HAT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.11.128"}], "href": "https://doi.org/10.1016/j.bbrc.2015.11.128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26654953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26654953"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yang Li, Li Zhang, Tingting Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.240531.114"}], "href": "https://doi.org/10.1101/gad.240531.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24835250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24835250"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "A M Makowski, R N Dutnall, A T Annunziato "}, {"type": "b", "children": [{"type": "t", "text": "Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C100549200"}], "href": "https://doi.org/10.1074/jbc.C100549200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11585814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11585814"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jiabao Song, Liza Ngo, Kaylyn Bell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chemoproteomic Profiling of Protein Substrates of a Major Lysine Acetyltransferase in the Native Cellular Context."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Chem Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acschembio.1c00935"}], "href": "https://doi.org/10.1021/acschembio.1c00935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35417122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35417122"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Prabakaran Nagarajan, Paula A Agudelo Garcia, Chitra C Iyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early-onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/acel.12992"}], "href": "https://doi.org/10.1111/acel.12992"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31290578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31290578"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Juliana I Tafrova, Stefan T Tafrov "}, {"type": "b", "children": [{"type": "t", "text": "Human histone acetyltransferase 1 (Hat1) acetylates lysine 5 of histone H2A in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-014-2036-0"}], "href": "https://doi.org/10.1007/s11010-014-2036-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24682716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24682716"}]}]}]}
Synonyms	KAT1
Proteins	HAT1_HUMAN
NCBI Gene ID	8520
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HAT1 has 9,087 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for HAT1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HAT1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HAT1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HAT1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HAT1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HAT1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HAT1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HAT1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HAT1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HAT1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HAT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HAT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HAT1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HAT1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HAT1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing HAT1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HAT1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing HAT1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing HAT1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HAT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HAT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing HAT1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HAT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HAT1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HAT1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HAT1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HAT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HAT1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HAT1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HAT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HAT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HAT1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.