| HGNC Family | G protein-coupled receptors |
| Name | hypocretin (orexin) receptor 2 |
| Description | The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Hypocretin receptor 2 (HCRTR2), also known as orexin receptor 2 (OX2R), plays multifaceted roles in both central and peripheral physiology. Central HCRTR2 signaling is critical for maintaining wakefulness and sleep stability, as demonstrated by animal models in which disruption of HCRTR2 leads to excessive sleepiness, fragmented sleep, and impaired non‐rapid eye movement sleep regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Moreover, HCRTR2 is pivotal in mediating orexin’s metabolic effects. Enhanced orexin–HCRTR2 signaling has been shown to increase energy expenditure, reduce food intake, and improve leptin sensitivity, thereby conferring resistance to diet‐induced obesity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the clinical arena, genetic studies have implicated HCRTR2 variants in the pathophysiology of cluster headache. In particular, several independent studies report that the G1246A (Val308Ile) polymorphism in HCRTR2 is associated with an increased risk of developing this severe neurovascular disorder."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": " Beyond headache, polymorphic variation in HCRTR2 may also contribute to other central disorders; altered receptor function has been linked to an elevated risk for Alzheimer’s disease and to gender‐specific vulnerability in panic disorder."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the molecular level, HCRTR2 exhibits complex signaling properties. In addition to coupling to mitogen‐activated protein kinase (MAPK) cascades in certain peripheral cells, HCRTR2 has been shown to form homo‐ and heterodimers (including with cannabinoid receptors), which may influence its trafficking and downstream signal transduction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Regulatory studies further reveal that HCRTR2 expression is the product of alternative transcripts controlled by distinct promoter elements, adding a layer of tissue‐specific and stimulus‐responsive control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Importantly, central orexin signaling via HCRTR2 extends its influence to other physiological domains. For instance, central HCRTR2 activation has been implicated in the augmentation of bone formation, while alterations in HCRTR2 signaling are associated with impaired cardiac function and systemic glucose homeostasis in heart failure models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Furthermore, age‐related declines in HCRTR2 mRNA expression in key brain regions may contribute to the emergence of sleep disturbances in the elderly."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the pivotal role of HCRTR2 as an integrative mediator of sleep–wake regulation, metabolic control, neurovascular integrity, and neuroendocrine as well as musculoskeletal homeostasis. The diverse actions of HCRTR2 render it a promising therapeutic target for disorders ranging from narcolepsy and cluster headache to metabolic and neurodegenerative diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jon T Willie, Richard M Chemelli, Christopher M Sinton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(03)00330-1"}], "href": "https://doi.org/10.1016/s0896-6273(03"}, {"type": "t", "text": "00330-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12797957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12797957"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Takatoshi Mochizuki, Elda Arrigoni, Jacob N Marcus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1012456108"}], "href": "https://doi.org/10.1073/pnas.1012456108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21368172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21368172"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "M Hondo, K Nagai, K Ohno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Physiol (Oxf) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1748-1716.2009.02032.x"}], "href": "https://doi.org/10.1111/j.1748-1716.2009.02032.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19694625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19694625"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiromasa Funato, Allen L Tsai, Jon T Willie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2008.10.010"}], "href": "https://doi.org/10.1016/j.cmet.2008.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19117547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19117547"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "I Rainero, S Gallone, W Valfrè, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.wnl.0000142424.65251.db"}], "href": "https://doi.org/10.1212/01.wnl.0000142424.65251.db"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15477554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15477554"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M Schürks, T Kurth, I Geissler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/01.wnl.0000215852.35329.34"}], "href": "https://doi.org/10.1212/01.wnl.0000215852.35329.34"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16554494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16554494"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Innocenzo Rainero, Elisa Rubino, Walter Valfrè, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Headache Pain (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10194-007-0383-x"}], "href": "https://doi.org/10.1007/s10194-007-0383-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17563843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17563843"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Innocenzo Rainero, Salvatore Gallone, Elisa Rubino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haplotype analysis confirms the association between the HCRTR2 gene and cluster headache."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Headache (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1526-4610.2008.01080.x"}], "href": "https://doi.org/10.1111/j.1526-4610.2008.01080.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18399985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18399985"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Claudia M Weller, Leopoldine A Wilbrink, Jeanine J Houwing-Duistermaat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cluster headache and the hypocretin receptor 2 reconsidered: a genetic association study and meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cephalalgia (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0333102414557839"}], "href": "https://doi.org/10.1177/0333102414557839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25398231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25398231"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Salvatore Gallone, Silvia Boschi, Elisa Rubino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Is HCRTR2 a genetic risk factor for Alzheimer's disease?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dement Geriatr Cogn Disord (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000359964"}], "href": "https://doi.org/10.1159/000359964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24969517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24969517"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kristina Annerbrink, Lars Westberg, Marie Olsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatr Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/YPG.0b013e328341a3db"}], "href": "https://doi.org/10.1097/YPG.0b013e328341a3db"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21666548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21666548"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Maria H Jäntti, Ilona Mandrika, Jyrki P Kukkonen "}, {"type": "b", "children": [{"type": "t", "text": "Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.02.026"}], "href": "https://doi.org/10.1016/j.bbrc.2014.02.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24530395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24530395"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jing Chen, Harpal S Randeva "}, {"type": "b", "children": [{"type": "t", "text": "Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20091755"}], "href": "https://doi.org/10.1042/BJ20091755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20156195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20156195"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wei Wei, Toshiyuki Motoike, Jing Y Krzeszinski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2014.03.016"}], "href": "https://doi.org/10.1016/j.cmet.2014.03.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24794976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24794976"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Marco V Perez, Aleksandra Pavlovic, Ching Shang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2015.09.061"}], "href": "https://doi.org/10.1016/j.jacc.2015.09.061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26653627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26653627"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Akira Terao, Anjali Apte-Deshpande, Stephen Morairty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0304-3940(02)00953-9"}], "href": "https://doi.org/10.1016/s0304-3940(02"}, {"type": "t", "text": "00953-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12399012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12399012"}]}]}]}
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| Synonyms | OX2R |
| Proteins | OX2R_HUMAN |
| NCBI Gene ID | 3062 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HCRTR2 has 2,712 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 92 datasets.
Click the + buttons to view associations for HCRTR2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by HCRTR2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HCRTR2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of HCRTR2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of HCRTR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of HCRTR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HCRTR2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HCRTR2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HCRTR2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HCRTR2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HCRTR2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HCRTR2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with HCRTR2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HCRTR2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HCRTR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HCRTR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HCRTR2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HCRTR2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HCRTR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HCRTR2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with HCRTR2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with HCRTR2 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with HCRTR2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with HCRTR2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by HCRTR2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with HCRTR2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HCRTR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HCRTR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with HCRTR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with HCRTR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HCRTR2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HCRTR2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of HCRTR2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing HCRTR2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with HCRTR2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with HCRTR2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HCRTR2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with HCRTR2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HCRTR2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HCRTR2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving HCRTR2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving HCRTR2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing HCRTR2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by HCRTR2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by HCRTR2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HCRTR2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HCRTR2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding HCRTR2 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| Guide to Pharmacology Protein Ligands of Receptors | ligands (protein) binding HCRTR2 receptor from the curated Guide to Pharmacology Protein Ligands of Receptors dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with HCRTR2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with HCRTR2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of HCRTR2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of HCRTR2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of HCRTR2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with HCRTR2 gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with HCRTR2 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with HCRTR2 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with HCRTR2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for HCRTR2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HCRTR2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving HCRTR2 protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HCRTR2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HCRTR2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HCRTR2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by HCRTR2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HCRTR2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of HCRTR2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by HCRTR2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for HCRTR2 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of HCRTR2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for HCRTR2 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HCRTR2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of HCRTR2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving HCRTR2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving HCRTR2 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving HCRTR2 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving HCRTR2 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of HCRTR2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HCRTR2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HCRTR2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HCRTR2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of HCRTR2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HCRTR2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HCRTR2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of HCRTR2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HCRTR2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| WikiPathways Pathways 2014 | pathways involving HCRTR2 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving HCRTR2 protein from the WikiPathways Pathways 2024 dataset. | |
