{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHDAC7 is a multifunctional class IIa histone deacetylase that primarily acts as a transcriptional corepressor. It engages in direct interactions with corepressor proteins (for example, SMRT) and transcription factors such as the MEF2 family to control gene expression programs critical for cell differentiation and apoptosis. In developing thymocytes, nuclear HDAC7 suppresses the orphan nuclear receptor Nur77, thereby regulating T‐cell negative selection, while caspase‐8 cleavage and kinase‐mediated phosphorylation signal its nuclear export to relieve repression. HDAC7 also partners with regulators such as Runx2, FoxA1/ERα, androgen receptor, and Mitf to modulate osteoblast differentiation, B‐cell lineage specification, and oncogene expression (e.g., c‐Myc). These diverse interactions emphasize its role in the transcriptional control of developmental and immune processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular and immune contexts, HDAC7 plays a central role in regulating endothelial cell function and angiogenesis. In response to vascular endothelial growth factor (VEGF) and hypoxic stimuli, kinases such as protein kinase D and MARK/Par‐1 phosphorylate HDAC7, triggering its nuclear export and consequent activation of VEGF‐responsive and hypoxia‐inducible gene programs. HDAC7 directly interacts with HIF‑1α to enhance transcription of genes critical for adaptive responses under low oxygen and, through its regulation of PDGF‐B expression and modulation of endothelial progenitor cell migration and tube formation, it helps control angiogenic processes. In parallel, alternative splicing and post‐translational modifications (for example, 14‑3‑3 binding and interaction with PML nuclear bodies) further refine HDAC7’s activity during inflammatory signaling in macrophages and other vascular cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of HDAC7 has been implicated in a variety of pathological conditions, highlighting its appeal as a therapeutic target. Pharmacological inhibition of HDAC7 activity or its suppression by specific microRNAs has been shown to restore mutant protein function in cystic fibrosis and attenuate oncogenic signaling in several cancers—including breast, glioblastoma, nasopharyngeal, and lung carcinomas—by altering key pathways such as STAT3 and c‐Myc signaling. 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