HIPK1 Gene

Name	homeodomain interacting protein kinase 1
Description	The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Homeodomain‐interacting protein kinase 1 (HIPK1) is an evolutionarily conserved nuclear serine/threonine kinase that integrates multiple signaling inputs to regulate cell proliferation, apoptosis, transcription, stress responses, and differentiation during both embryonic development and disease. In developing embryos, HIPK1 functions (often redundantly with its family members) to modulate morphogenetic signals—including those mediated by Sonic hedgehog and Wnt/β‐catenin—to control neural fold proliferation and proper cell fate determination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the nucleus, HIPK1 phosphorylates transcriptional regulators such as Daxx, thereby redistributing Daxx within nuclear subdomains and tempering its repressive activity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and it targets p53—phosphorylating serine-15—to enhance p53’s transactivation potential, which contributes to cell cycle control and apoptotic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Under stressful conditions such as TNFα stimulation, HIPK1 undergoes desumoylation and translocates transiently to the cytoplasm, a process that is critical for the activation of the ASK1–JNK/p38 pathway and the ensuing stress-induced apoptotic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In addition, HIPK1 modulates the balance between proliferation and cell cycle exit in neural stem/progenitor cells by influencing β‐catenin–dependent transcriptional programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In oncogenic settings, HIPK1 plays multifaceted roles by modulating key regulators of tumorigenesis. For instance, its phosphorylation of the intrinsically disordered protein PAGE4 alters PAGE4’s conformation and its subsequent interaction with the AP-1 transcription factor c-Jun, thereby influencing the development and progression of malignancies such as prostate and lung cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": " Moreover, modulation of HIPK1 levels—either directly or via microRNAs such as miR-3065-5p—has been shown to affect cell proliferation and epithelial–mesenchymal transition in melanoma and lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In cultured human cells, inhibition or genetic knockout of HIPK1 has been associated with enhanced recombinant protein expression, suggesting that HIPK1 may also influence translational output and hold promise for biotechnological applications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in inflammatory and oxidative stress contexts such as acute lung injury, elevated HIPK1 levels are linked to increased inflammation and oxidative markers, whereas HIPK1 knockdown reduces these effects and enhances protective autophagy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, HIPK1 emerges as a pivotal regulator that orchestrates diverse cellular processes—from embryonic tissue patterning and transcriptional control to stress signaling and oncogenic modulation—highlighting its potential as both a biomarker and a therapeutic target in various pathological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kyoichi Isono, Kazumi Nemoto, Yuanyuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.7.2758-2771.2006"}], "href": "https://doi.org/10.1128/MCB.26.7.2758-2771.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16537918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16537918"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sarah H Louie, Xiao Yong Yang, William H Conrad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0004310"}], "href": "https://doi.org/10.1371/journal.pone.0004310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19183803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19183803"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jeffrey A Ecsedy, Jennifer S Michaelson, Philip Leder "}, {"type": "b", "children": [{"type": "t", "text": "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.3.950-960.2003"}], "href": "https://doi.org/10.1128/MCB.23.3.950-960.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12529400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12529400"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Seiji Kondo, Ying Lu, Michael Debbas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0530308100"}], "href": "https://doi.org/10.1073/pnas.0530308100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12702766"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12702766"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christophe Rey, Isabelle Soubeyran, Isabelle Mahouche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIPK1 drives p53 activation to limit colorectal cancer cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.24927"}], "href": "https://doi.org/10.4161/cc.24927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23676219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23676219"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xianghong Li, Rong Zhang, Dianhong Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M414262200"}], "href": "https://doi.org/10.1074/jbc.M414262200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15701637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15701637"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Cinzia Marinaro, Maria Pannese, Franziska Weinandy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt signaling has opposing roles in the developing and the adult brain that are modulated by Hipk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cereb Cortex (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cercor/bhr320"}], "href": "https://doi.org/10.1093/cercor/bhr320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22095214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22095214"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Prakash Kulkarni, Mohit Kumar Jolly, Dongya Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1700082114"}], "href": "https://doi.org/10.1073/pnas.1700082114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28289210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28289210"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Prakash Kulkarni, A Keith Dunker, Keith Weninger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate-associated gene 4 (PAGE4), an intrinsically disordered cancer/testis antigen, is a novel therapeutic target for prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Androl (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4103/1008-682X.181818"}], "href": "https://doi.org/10.4103/1008-682X.181818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27270343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27270343"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qiang Zhu, Yun Li, Lina Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2000283"}], "href": "https://doi.org/10.1080/21655979.2021.2000283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34723781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34723781"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ravi Salgia, Mohit Kumar Jolly, Tanya Dorff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/jcm7060156"}], "href": "https://doi.org/10.3390/jcm7060156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29914187"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29914187"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nadezhda Palkina, Anna Komina, Maria Aksenenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-204-5p and miR-3065-5p exert antitumor effects on melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2018.8443"}], "href": "https://doi.org/10.3892/ol.2018.8443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29844810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29844810"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sarah Inwood, Eugen Buehler, Michael Betenbaugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biotechnol J (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/biot.201700342"}], "href": "https://doi.org/10.1002/biot.201700342"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28987030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28987030"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sarah Inwood, Laura Abaandou, Michael Betenbaugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Improved protein expression in HEK293 cells by over-expressing miR-22 and knocking-out its target gene, HIPK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbt.2019.08.004"}], "href": "https://doi.org/10.1016/j.nbt.2019.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31425885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31425885"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lan Meng, Xin Zhao, Hongxia Zhang "}, {"type": "b", "children": [{"type": "t", "text": "HIPK1 Interference Attenuates Inflammation and Oxidative Stress of Acute Lung Injury via Autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.912507"}], "href": "https://doi.org/10.12659/MSM.912507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30734722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30734722"}]}]}]}
Synonyms	MYAK, NBAK2
Proteins	HIPK1_HUMAN
NCBI Gene ID	204851
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HIPK1 has 6,385 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for HIPK1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HIPK1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by HIPK1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HIPK1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HIPK1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HIPK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HIPK1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HIPK1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HIPK1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HIPK1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HIPK1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HIPK1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HIPK1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with HIPK1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HIPK1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HIPK1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HIPK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HIPK1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HIPK1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HIPK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HIPK1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing HIPK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing HIPK1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HIPK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HIPK1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HIPK1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HIPK1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HIPK1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HIPK1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of HIPK1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HIPK1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HIPK1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HIPK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HIPK1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HIPK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HIPK1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HIPK1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HIPK1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HIPK1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HIPK1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HIPK1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HIPK1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.