HIST1H2BA Gene

HGNC Family	Histones
Name	histone cluster 1, H2ba
Description	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
Synonyms	BA317E16.3, hTSH2B, STBP, TSH2B, H2BFU, TSH2B.1, TH2B
Proteins	H2B1A_HUMAN
NCBI Gene ID	255626
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HIST1H2BA has 1,765 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 55 datasets.

Click the + buttons to view associations for HIST1H2BA from the datasets below.

If available, associations are ranked by standardized value

Harmonizome

HIST1H2BA Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference:

Funding

	Dataset	Summary
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HIST1H2BA gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HIST1H2BA gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HIST1H2BA gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CHEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HIST1H2BA gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	CHEA Transcription Factor Targets	transcription factors binding the promoter of HIST1H2BA gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HIST1H2BA protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HIST1H2BA protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	CORUM Protein Complexes	protein complexs containing HIST1H2BA protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HIST1H2BA gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HIST1H2BA gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HIST1H2BA gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HIST1H2BA gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Assocation Evidence Scores	diseases co-occuring with HIST1H2BA gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HIST1H2BA gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HIST1H2BA gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HIST1H2BA gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HIST1H2BA from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HIST1H2BA gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HIST1H2BA gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HIST1H2BA from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of HIST1H2BA gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations	biological processes involving HIST1H2BA gene from the curated GO Biological Process Annotations dataset.
	GO Cellular Component Annotations	cellular components containing HIST1H2BA protein from the curated GO Cellular Component Annotations dataset.
	GO Molecular Function Annotations	molecular functions performed by HIST1H2BA gene from the curated GO Molecular Function Annotations dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of HIST1H2BA gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GWASdb SNP-Disease Associations	diseases associated with HIST1H2BA gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
	GWASdb SNP-Phenotype Associations	phenotypes associated with HIST1H2BA gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of HIST1H2BA gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	HPA Tissue Protein Expression Profiles	tissues with high or low expression of HIST1H2BA protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
	HPM Cell Type and Tissue Protein Expression Profiles	cell types and tissues with high or low expression of HIST1H2BA protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for HIST1H2BA protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of HIST1H2BA gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of HIST1H2BA gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	LOCATE Curated Protein Localization Annotations	cellular components containing HIST1H2BA protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
	LOCATE Predicted Protein Localization Annotations	cellular components predicted to contain HIST1H2BA protein from the LOCATE Predicted Protein Localization Annotations dataset.
	MiRTarBase microRNA Targets	microRNAs targeting HIST1H2BA gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of HIST1H2BA gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	NURSA Protein Complexes	protein complexs containing HIST1H2BA protein recovered by IP-MS from the NURSA Protein Complexes dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for HIST1H2BA from the Pathway Commons Protein-Protein Interactions dataset.
	Phosphosite Textmining Biological Term Annotations	biological terms co-occuring with HIST1H2BA protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
	PID Pathways	pathways involving HIST1H2BA protein from the PID Pathways dataset.
	Reactome Pathways	pathways involving HIST1H2BA protein from the Reactome Pathways dataset.
	Roadmap Epigenomics Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HIST1H2BA gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
	TargetScan Predicted Conserved microRNA Targets	microRNAs regulating expression of HIST1H2BA gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
	TCGA Signatures of Differentially Expressed Genes for Tumors	tissue samples with high or low expression of HIST1H2BA gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of HIST1H2BA protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores	tissues with high expression of HIST1H2BA protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with HIST1H2BA protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
	TRANSFAC Curated Transcription Factor Targets	transcription factors binding the promoter of HIST1H2BA gene in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.
	TRANSFAC Predicted Transcription Factor Targets	transcription factors regulating expression of HIST1H2BA gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.