HLA-L Gene

HGNC Family Histocompatibility complex (HLA)
Name major histocompatibility complex, class I, L (pseudogene)
Description Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class I. Predicted to be located in lumenal side of endoplasmic reticulum membrane and phagocytic vesicle membrane. Predicted to be part of MHC class I protein complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts offer valuable insights into diverse regulatory molecules that affect cell differentiation and tissue homeostasis, none of them address or mention HLA-L. Instead, the studies focus on key factors such as chromatin remodeling subunits, signaling regulators, and noncoding RNAs that orchestrate developmental processes. For example, one study demonstrates that the BAF45a subunit of SWI/SNF-like complexes is essential for the maintenance of adult hematopoietic stem cells and proper myeloid development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional work highlights the dual nature of the lncRNA TINCR. One investigation reveals that TINCR encodes a conserved ubiquitin‐like protein, TUBL, which enhances keratinocyte proliferation and expedites skin regeneration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In a related study, reduced levels of TINCR were implicated in cardiomyocyte hypertrophy via a regulatory axis involving miR‑31‑5p and PRKCE."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther investigations extend these themes by exploring isoform switching in chromatin remodelers and the role of nuclear pore proteins. Differential expression of PHF10 isoforms was observed during neuronal and muscle differentiation, suggesting that such variation modulates the target selectivity of the PBAF complex."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, analysis of NUP210L—a testis‐specific nucleoporin—revealed its association with spermatid nuclear morphology and motility, although its precise role in nuclear compaction appears to vary between species."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, while these studies elucidate several mechanisms of developmental and epigenetic regulation, they do not provide any information on HLA-L."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Veneta Krasteva, Gerald R Crabtree, Julie A Lessard "}, {"type": "b", "children": [{"type": "t", "text": "The BAF45a/PHF10 subunit of SWI/SNF-like chromatin remodeling complexes is essential for hematopoietic stem cell maintenance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Hematol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.exphem.2016.11.008"}], "href": "https://doi.org/10.1016/j.exphem.2016.11.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27931852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27931852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hoogeun Song, Hyunsoo Kim, Kyunghee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.480"}], "href": "https://doi.org/10.1038/emboj.2011.480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22227519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22227519"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Akihiro Nita, Akinobu Matsumoto, Ronghao Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A ubiquitin-like protein encoded by the \"noncoding\" RNA TINCR promotes keratinocyte proliferation and wound healing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1009686"}], "href": "https://doi.org/10.1371/journal.pgen.1009686"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34351912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34351912"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hao Li, Hongtao Shi, Fan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA Tincr regulates PKCɛ expression in a miR-31-5p-dependent manner in cardiomyocyte hypertrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Naunyn Schmiedebergs Arch Pharmacol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00210-020-01847-9"}], "href": "https://doi.org/10.1007/s00210-020-01847-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32157348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32157348"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D O Bayramova, A M Azieva, A V Feoktistov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dokl Biochem Biophys (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S1607672923700643"}], "href": "https://doi.org/10.1134/S1607672923700643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38189889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38189889"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maha Al Dala Ali, Guy Longepied, Aurore Nicolet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spermatozoa in mice lacking the nucleoporin NUP210L show defects in head shape and motility but not in nuclear compaction or histone replacement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.14468"}], "href": "https://doi.org/10.1111/cge.14468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38129135"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38129135"}]}]}]}
Synonyms HLA-92, HLAL, HLA92
NCBI Gene ID 3139
API
Download Associations
Predicted Functions View HLA-L's ARCHS4 Predicted Functions.
Co-expressed Genes View HLA-L's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HLA-L's ARCHS4 Predicted Functions.

Functional Associations

HLA-L has 2,141 functional associations with biological entities spanning 6 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 26 datasets.

Click the + buttons to view associations for HLA-L from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of HLA-L gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of HLA-L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of HLA-L gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of HLA-L gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of HLA-L gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HLA-L gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of HLA-L gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of HLA-L gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HLA-L gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HLA-L gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of HLA-L gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GAD Gene-Disease Associations diseases associated with HLA-L gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing HLA-L from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of HLA-L gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of HLA-L gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HLA-L gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with HLA-L gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with HLA-L gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of HLA-L gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of HLA-L gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of HLA-L gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of HLA-L gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of HLA-L gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of HLA-L gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HLA-L gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of HLA-L gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.