{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HNRNPCL2, also known as RALY, has been demonstrated to play a pivotal role in colorectal cancer by acting as an RNA‐binding protein and an essential component of the Drosha microprocessor complex. In this context, HNRNPCL2 facilitates the post‐transcriptional processing of a specific subset of microRNAs—miR‑483, miR‑676, and miR‑877—via an N6‑methyladenosine–mediated mechanism activated under reactive oxygen species stress. The mature miRNAs, in turn, downregulate key metabolism‐associated genes (ATP5I, ATP5G1, ATP5G3, and CYC1), thereby reprogramming mitochondrial metabolism, which contributes to enhanced tumor aggressiveness and correlates with poor prognosis in colorectal cancer patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, comprehensive whole‐exome sequencing studies in endometrial cancer have revealed a range of high‐frequency mutation sites across multiple genes, including members of the heterogeneous nuclear ribonucleoprotein family. Although the specific functional consequences of HNRNPCL2 alterations were not fully delineated in that analysis, the data underscore the broader clinical relevance of genetic aberrations in this family of RNA‐binding proteins in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight a metabolism‑centric oncogenic role for HNRNPCL2 in colorectal cancer and suggest that targeting its regulatory network may offer a promising therapeutic strategy.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lei Sun, Arabella Wan, Zhuolong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2020-320652"}], "href": "https://doi.org/10.1136/gutjnl-2020-320652"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33219048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33219048"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuan Gao, Xiuping Zhang, Tian Wang, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HNRNPCL1, PRAMEF1, CFAP74"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "DFFB"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ": Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S262421"}], "href": "https://doi.org/10.2147/CMAR.S262421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33177874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33177874"}]}]}]}