HNRNPUL1 Gene

Name	heterogeneous nuclear ribonucleoprotein U-like 1
Description	This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HNRNPUL1 is a multifunctional RNA‐binding protein belonging to the heterogeneous nuclear ribonucleoprotein family that participates in diverse cellular processes. A number of studies indicate that HNRNPUL1 plays a key role in the DNA damage response. For example, it has been shown to interact with partners such as BRCA1 to promote DNA end resection and homologous recombination repair processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Post‐translational modifications, such as arginine methylation by PRMT1, are critical for its ability to associate with repair factors including NBS1 and PARP1 and to be recruited efficiently to double‐strand breaks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies have linked variants in HNRNPUL1 to an elevated risk of early‐onset myocardial infarction"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", suggesting that its activity may also influence cardiovascular pathology. Originally identified as E1B‐AP5, HNRNPUL1 has been implicated in RNA processing and nuclear export pathways, and its interaction with the tumor suppressor p53 suggests further regulatory roles in oncogenic transformation and viral infection contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, HNRNPUL1 has been reported to act as a negative regulator of NF‑κB–mediated inflammation by competing for binding at κB sites, thereby constraining the magnitude and duration of inflammatory responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Dysregulated expression of HNRNPUL1 has also been observed in certain cancers, as lower levels have been associated with advanced disease in renal cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight HNRNPUL1 as a critical mediator linking RNA metabolism with the maintenance of genomic stability. Its functions in DNA repair, RNA processing, and modulation of inflammatory and oncogenic pathways suggest that alterations in HNRNPUL1 activity may have broad implications for disease susceptibility and progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vivek Sharma, Simran Khurana, Nard Kubben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A BRCA1-interacting lncRNA regulates homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201540437"}], "href": "https://doi.org/10.15252/embr.201540437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26412854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26412854"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gayathri Gurunathan, Zhenbao Yu, Yan Coulombe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep10475"}], "href": "https://doi.org/10.1038/srep10475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26020839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26020839"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zehui Hong, Jie Jiang, Jiaolong Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of hnRPUL1 involved in DNA damage response is related to PARP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0060208"}], "href": "https://doi.org/10.1371/journal.pone.0060208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23577092"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23577092"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dov Shiffman, Charles M Rowland, Judy Z Louie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/01.ATV.0000226543.77214.e4"}], "href": "https://doi.org/10.1161/01.ATV.0000226543.77214.e4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16690874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16690874"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Julia Kzhyshkowska, Andre Rusch, Hans Wolf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20021281"}], "href": "https://doi.org/10.1042/BJ20021281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12489984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12489984"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Paola M Barral, André Rusch, Andrew S Turnell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The interaction of the hnRNP family member E1B-AP5 with p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.03.095"}], "href": "https://doi.org/10.1016/j.febslet.2005.03.095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15907477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15907477"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Zhongfei Ma, Yumei Zhou, Yuyang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RNA-binding protein hnRNP UL1 binds κB sites to attenuate NF-κB-mediated inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2022.102828"}], "href": "https://doi.org/10.1016/j.jaut.2022.102828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35429914"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35429914"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ting Xu, Qing Zou, Jing Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-140390"}], "href": "https://doi.org/10.3233/CBM-140390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24595077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24595077"}]}]}]}
Synonyms	HNRPUL1, E1BAP5, E1B-AP5
Proteins	HNRL1_HUMAN
NCBI Gene ID	11100
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HNRNPUL1 has 8,672 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for HNRNPUL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HNRNPUL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HNRNPUL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HNRNPUL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HNRNPUL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HNRNPUL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HNRNPUL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HNRNPUL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HNRNPUL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HNRNPUL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HNRNPUL1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HNRNPUL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HNRNPUL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HNRNPUL1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HNRNPUL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HNRNPUL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HNRNPUL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HNRNPUL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HNRNPUL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HNRNPUL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing HNRNPUL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing HNRNPUL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HNRNPUL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HNRNPUL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing HNRNPUL1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HNRNPUL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HNRNPUL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HNRNPUL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HNRNPUL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HNRNPUL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HNRNPUL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HNRNPUL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HNRNPUL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HNRNPUL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HNRNPUL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HNRNPUL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HNRNPUL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HNRNPUL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HNRNPUL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HNRNPUL1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HNRNPUL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HNRNPUL1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.