HOXA10 Gene

HGNC Family	Homeoboxes
Name	homeobox A10
Description	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOXA10 is a highly conserved homeobox transcription factor that plays multifaceted roles in embryonic development and adult tissue function. In hematopoietic cells, aberrant up‐regulation of HOXA10 driven by disruptions in epigenetic regulators—including loss of Polycomb repressive complex 2 function due to ASXL1 mutations, NUP98 fusion oncoproteins, and MLL rearrangements—promotes leukemic transformation, sustains leukemic cell survival, and contributes to differentiation arrest. Moreover, microRNAs (for example, miR‑204) contribute to these oncogenic processes by post‐transcriptionally targeting HOXA10, thus further modulating the leukemic gene expression program."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the reproductive tract, HOXA10 is essential for proper uterine development and endometrial receptivity. It directly regulates key downstream targets—for instance, the β3‐integrin subunit—to mediate embryo implantation, and its tightly controlled expression is fundamental for establishing the receptive state of the endometrium. Aberrant promoter methylation and consequent reduced HOXA10 expression have been implicated in endometriosis and infertility, while changes in HOXA10 levels are also linked with altered patterning of the female reproductive tract."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, HOXA10 contributes directly to skeletal development by promoting osteoblast differentiation; it activates critical osteogenic factors such as Runx2 and supports the expression of phenotypic genes essential for bone formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Collectively, these studies underscore the diverse functions of HOXA10 in normal development and disease, demonstrating that its precise regulation is vital for hematopoietic lineage commitment, uterine receptivity, and skeletal morphogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Omar Abdel-Wahab, Mazhar Adli, Lindsay M LaFave, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2012.06.032"}], "href": "https://doi.org/10.1016/j.ccr.2012.06.032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22897849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22897849"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang G Wang, Ling Cai, Martina P Pasillas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1608"}], "href": "https://doi.org/10.1038/ncb1608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17589499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17589499"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joerg Faber, Andrei V Krivtsov, Matthew C Stubbs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA9 is required for survival in human MLL-rearranged acute leukemias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-09-113597"}], "href": "https://doi.org/10.1182/blood-2007-09-113597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19056693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19056693"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Adolfo A Ferrando, Scott A Armstrong, Donna S Neuberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-10-3221"}], "href": "https://doi.org/10.1182/blood-2002-10-3221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12637319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12637319"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sheryl M Gough, Christopher I Slape, Peter D Aplan "}, {"type": "b", "children": [{"type": "t", "text": "NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-07-328880"}], "href": "https://doi.org/10.1182/blood-2011-07-328880"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21948299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21948299"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gregory D Gregory, Christopher R Vakoc, Tanya Rozovskaia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00993-07"}], "href": "https://doi.org/10.1128/MCB.00993-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17923682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17923682"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ramiro Garzon, Michela Garofalo, Maria Paola Martelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0800135105"}], "href": "https://doi.org/10.1073/pnas.0800135105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18308931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18308931"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yan Wu, Gloria Halverson, Zainab Basir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Obstet Gynecol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajog.2005.01.034"}], "href": "https://doi.org/10.1016/j.ajog.2005.01.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16098858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16098858"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dilek Cermik, Belgin Selam, Hugh S Taylor "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2002-021072"}], "href": "https://doi.org/10.1210/jc.2002-021072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12519859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12519859"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Gaurang S Daftary, Patrick J Troy, Catherine N Bagot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/mend.16.3.0792"}], "href": "https://doi.org/10.1210/mend.16.3.0792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11875117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11875117"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alysson Zanatta, André M Rocha, Filomena M Carvalho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-010-9471-y"}], "href": "https://doi.org/10.1007/s10815-010-9471-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20821045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20821045"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hongling Du, Hugh S Taylor "}, {"type": "b", "children": [{"type": "t", "text": "The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cold Spring Harb Perspect Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/cshperspect.a023002"}], "href": "https://doi.org/10.1101/cshperspect.a023002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26552702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26552702"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Matthew T Dyson, Damian Roqueiro, Diana Monsivais, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1004158"}], "href": "https://doi.org/10.1371/journal.pgen.1004158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24603652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24603652"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Mathias Mericskay, Jan Kitajewski, David Sassoon "}, {"type": "b", "children": [{"type": "t", "text": "Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01090"}], "href": "https://doi.org/10.1242/dev.01090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15073149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15073149"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mohammad Q Hassan, Rahul Tare, Suk Hee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01544-06"}], "href": "https://doi.org/10.1128/MCB.01544-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17325044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17325044"}]}]}]}
Synonyms	HOX1H, HOX1.8
Proteins	HXA10_HUMAN
NCBI Gene ID	3206
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HOXA10 has 10,274 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for HOXA10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HOXA10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by HOXA10 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HOXA10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HOXA10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HOXA10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HOXA10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HOXA10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HOXA10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HOXA10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HOXA10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HOXA10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HOXA10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of HOXA10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HOXA10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HOXA10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HOXA10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HOXA10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HOXA10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HOXA10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HOXA10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HOXA10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HOXA10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of HOXA10 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HOXA10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate HOXA10 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HOXA10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HOXA10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HOXA10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HOXA10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HOXA10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HOXA10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HOXA10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HOXA10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HOXA10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HOXA10 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HOXA10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.