HOXA5 Gene

HGNC Family	Homeoboxes
Name	homeobox A5
Description	In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n HOXA5 is emerging as a multifunctional homeobox transcription factor with key roles in both normal development and cancer pathogenesis. In the vascular system, HOXA5 acts as an important anti‐angiogenic factor by downregulating pro‐angiogenic genes and upregulating inhibitors of angiogenesis, thereby helping to maintain endothelial quiescence ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In non‐small cell lung cancer, HOXA5 is targeted by non‐coding RNAs such as HOTAIR and miR-196a; its downregulation is associated with enhanced tumor cell invasion, metastasis, and poor clinical outcome ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "]. In hematologic malignancies, abnormal HOXA cluster expression—including altered HOXA5 levels—has been implicated in leukemogenesis, and re-expression of HOXA5 can promote differentiation; indeed, in chronic myeloid leukemia models, restoration of HOXA5 induces granulocytic differentiation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "]. In breast cancer cells, HOXA5 re-expression triggers apoptosis through p53-dependent and p53-independent mechanisms, with evidence linking its activity to the regulation of p53 transcription via HDAC8, as well as to caspase-mediated cell death ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. Beyond its tumor suppressor functions, HOXA5 is also critical during normal development; it represses intestinal stem cell fate by modulating Wnt signaling, thereby enforcing differentiation outside the intestinal crypt ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "]. Moreover, HOXA5 is essential for proper organ regionalization and patterning—as exemplified by its role in stomach development, where loss of HOXA5 disrupts mesenchymal–epithelial signaling that defines gastric identity, and in the formation of respiratory motor neuron connectivity, where it helps organize the phrenic motor column ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "]. Collectively, these studies indicate that appropriate HOXA5 expression is crucial for maintaining differentiation, restraining angiogenesis, and preventing malignant transformation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yun Chen, David H Gorski "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-104133"}], "href": "https://doi.org/10.1182/blood-2007-07-104133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957028"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kim Rhoads, Gemma Arderiu, Aubri Charboneau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for Hox A5 in regulating angiogenesis and vascular patterning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lymphat Res Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/lrb.2005.3.240"}], "href": "https://doi.org/10.1089/lrb.2005.3.240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16379594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16379594"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiang-hua Liu, Zhi-li Liu, Ming Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-464"}], "href": "https://doi.org/10.1186/1471-2407-13-464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24103700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24103700"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang-hua Liu, Kai-hua Lu, Ke-ming Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-12-348"}], "href": "https://doi.org/10.1186/1471-2407-12-348"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22876840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22876840"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gordon Strathdee, Tessa L Holyoake, Alyson Sim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-07-0919"}], "href": "https://doi.org/10.1158/1078-0432.CCR-07-0919"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17785556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17785556"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "W Yan, S Liu, E Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.81"}], "href": "https://doi.org/10.1038/onc.2012.81"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22391568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22391568"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hexin Chen, Seung Chung, Saraswati Sukumar "}, {"type": "b", "children": [{"type": "t", "text": "HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.24.2.924-935.2004"}], "href": "https://doi.org/10.1128/MCB.24.2.924-935.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14701762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14701762"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Paloma Ordóñez-Morán, Caroline Dafflon, Masamichi Imajo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2015.11.001"}], "href": "https://doi.org/10.1016/j.ccell.2015.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26678341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26678341"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Josée Aubin, Ugo Déry, Margot Lemieux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.129.17.4075"}], "href": "https://doi.org/10.1242/dev.129.17.4075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12163410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12163410"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Polyxeni Philippidou, Carolyn M Walsh, Josée Aubin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sustained Hox5 gene activity is required for respiratory motor neuron development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.3242"}], "href": "https://doi.org/10.1038/nn.3242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23103965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23103965"}]}]}]}
Synonyms	HOX1.3, HOX1C
Proteins	HXA5_HUMAN
NCBI Gene ID	3202
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HOXA5 has 8,921 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for HOXA5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HOXA5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HOXA5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HOXA5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HOXA5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HOXA5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HOXA5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HOXA5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HOXA5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HOXA5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HOXA5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HOXA5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HOXA5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HOXA5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HOXA5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HOXA5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HOXA5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HOXA5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HOXA5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HOXA5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HOXA5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HOXA5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HOXA5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with HOXA5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HOXA5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HOXA5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HOXA5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HOXA5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HOXA5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HOXA5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HOXA5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HOXA5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HOXA5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HOXA5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HOXA5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with HOXA5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing HOXA5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of HOXA5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of HOXA5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.