HPGD Gene

HGNC Family	Short chain dehydrogenase/reductase superfamily (SDR)
Name	hydroxyprostaglandin dehydrogenase 15-(NAD)
Description	This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH), encoded by the HPGD gene, is the key enzyme responsible for the inactivation of bioactive prostaglandins—most notably prostaglandin E₂ (PGE₂). By catalyzing the oxidation of the 15‐hydroxyl group on PGE₂, 15‐PGDH limits the accumulation of this proinflammatory and protumorigenic lipid mediator. Reduced expression or activity of HPGD has been implicated in several pathological conditions. In the colorectum and stomach, for example, down‐regulation of HPGD—whether through promoter methylation, histone deacetylation, or microRNA‐mediated targeting (e.g. by miR‐21)—leads to elevated local PGE₂ levels that foster neoplastic transformation and tumor progression (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": " In this context, HPGD functions as a tumor suppressor by curtailing COX-2–mediated PGE₂ signaling, and its low expression is associated with increased cancer risk and worse clinical outcomes. Conversely, restoration or up‐regulation of HPGD—by agents such as calcitriol that stimulate its expression or through pharmacological inhibition of HDACs—reduces PGE₂ levels and may improve responses to chemopreventive strategies including aspirin treatment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": " Outside the neoplastic context, loss-of-function mutations in HPGD have been shown to cause primary hypertrophic osteoarthropathy (PHO), a condition characterized by digital clubbing and periostosis due to persistently elevated PGE₂ levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, regulation of HPGD plays a role in normal physiological processes such as parturition, where TLR-4–mediated down-regulation of prostaglandin catabolism contributes to the onset of labor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Moreover, expression studies in prostate cancer suggest that high HPGD levels in advanced, androgen receptor–overexpressing tumors may have distinct implications."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Finally, experimental inhibition of HPGD can enhance tissue regeneration in several organs, underscoring its broader role in modulating prostaglandin bioavailability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael G Backlund, Jason R Mann, Vijaykumar R Holla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M411221200"}], "href": "https://doi.org/10.1074/jbc.M411221200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15542609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15542609"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Min Yan, Ronald M Rerko, Petra Platzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0406142101"}], "href": "https://doi.org/10.1073/pnas.0406142101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15574495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15574495"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seung-Jae Myung, Ronald M Rerko, Min Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0603235103"}], "href": "https://doi.org/10.1073/pnas.0603235103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16880406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16880406"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Vijaykumar R Holla, Michael G Backlund, Peying Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of prostaglandin transporters in colorectal neoplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Prev Res (Phila) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1940-6207.CAPR-07-0009"}], "href": "https://doi.org/10.1158/1940-6207.CAPR-07-0009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19138942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19138942"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexandra Thiel, Aparna Ganesan, Johanna Mrena, et al. "}, {"type": "b", "children": [{"type": "t", "text": "15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-2518"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-2518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19584167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19584167"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kosuke Mima, Reiko Nishihara, Juhong Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-15-2173"}], "href": "https://doi.org/10.1158/1078-0432.CCR-15-2173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26957558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26957558"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lu Lu, Kathleen Byrnes, Chang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-13-0419"}], "href": "https://doi.org/10.1158/1541-7786.MCR-13-0419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24699315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24699315"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Birgit Hoeft, Jakob Linseisen, Lars Beckmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgp325"}], "href": "https://doi.org/10.1093/carcin/bgp325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20042636"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20042636"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Aruna V Krishnan, Srilatha Swami, Lihong Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2009-0855"}], "href": "https://doi.org/10.1210/en.2009-0855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19906814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19906814"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michael G Backlund, Jason R Mann, Vijaykumar R Holla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-2893"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-2893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19010907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19010907"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Stephen P Fink, Mai Yamauchi, Reiko Nishihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Transl Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scitranslmed.3008481"}], "href": "https://doi.org/10.1126/scitranslmed.3008481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24760190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24760190"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sandeep Uppal, Christine P Diggle, Ian M Carr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.153"}], "href": "https://doi.org/10.1038/ng.153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18500342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18500342"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wenke Seifert, Jirko Kühnisch, Beyhan Tüysüz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22042"}], "href": "https://doi.org/10.1002/humu.22042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22331663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22331663"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hao Wang, Emmet Hirsch "}, {"type": "b", "children": [{"type": "t", "text": "Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Reprod (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1095/biolreprod.103.019620"}], "href": "https://doi.org/10.1095/biolreprod.103.019620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12904319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12904319"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Paula Vainio, Santosh Gupta, Kirsi Ketola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2010.10.002"}], "href": "https://doi.org/10.1016/j.ajpath.2010.10.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21281786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21281786"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yongyou Zhang, Amar Desai, Sung Yeun Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aaa2340"}], "href": "https://doi.org/10.1126/science.aaa2340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26068857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26068857"}]}]}]}
Synonyms	15-PGDH, PGDH1, PHOAR1, SDR36C1, PGDH
Proteins	PGDH_HUMAN
NCBI Gene ID	3248
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

HPGD has 12,865 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 116 datasets.

Click the + buttons to view associations for HPGD from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

HPGD Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPGD gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPGD gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of HPGD gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of HPGD gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of HPGD gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of HPGD gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of HPGD gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of HPGD gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of HPGD gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of HPGD gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of HPGD gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with HPGD protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with HPGD gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPGD gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of HPGD gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of HPGD gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with HPGD gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with HPGD gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of HPGD gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing HPGD protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing HPGD protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with HPGD protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with HPGD protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of HPGD gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with HPGD gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with HPGD gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with HPGD gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by HPGD gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with HPGD gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with HPGD gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with HPGD gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with HPGD gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for HPGD protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at HPGD gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of HPGD gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of HPGD gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing HPGD from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with HPGD gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with HPGD gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of HPGD gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.