HSD11B2 Gene

HGNC Family Short chain dehydrogenase/reductase superfamily (SDR)
Name hydroxysteroid (11-beta) dehydrogenase 2
Description There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Summary
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Reduced placental expression or activity—whether through maternal stress, adverse socioeconomic conditions, environmental toxicants like cadmium, hypoxia, or epigenetic modifications—has been linked with altered fetal growth, impaired neurodevelopment, and long‐term programming of blood pressure and metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic and epigenetic variation in HSD11B2 has further been implicated in the regulation of salt sensitivity and blood pressure. Specific promoter polymorphisms and single‐nucleotide variations have been associated with reduced enzyme activity and a higher cortisol/cortisone ratio, mechanisms that contribute to conditions such as apparent mineralocorticoid excess and salt‐sensitive hypertension."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, HSD11B2 expression in the developing brain is pivotal for neuroprotection; by inactivating glucocorticoids, it safeguards neural progenitors from the potentially deleterious effects of excessive glucocorticoid exposure, thus contributing to normal cerebellar and central nervous system development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in nonrenal tissues such as the cardiovascular system, altered HSD11B2 activity contributes to adverse remodelling, inflammation, and ultimately atherosclerotic and fibrotic changes. Collectively, these multifaceted roles underscore HSD11B2’s function as a critical prereceptor regulator of glucocorticoid action, ensuring proper mineralocorticoid receptor activation, maintenance of electrolyte balance, and normal fetal programming. Alterations in its expression or activity—whether due to environmental influences, maternal stress, or genetic polymorphisms—can have profound consequences for postnatal cardiovascular, renal, and neurobehavioral health."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "24"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, HSD11B2 is indispensable for glucocorticoid metabolism and represents a key molecular node linking the intrauterine environment to long‐term health outcomes, including blood pressure regulation, neurodevelopment, and cardiovascular homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "35"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rasoul Alikhani-Koopaei, Fatemeh Fouladkou, Felix J Frey, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00356.2005"}], "href": "https://doi.org/10.1152/ajpendo.00356.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16144812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16144812"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "J Dy, H Guan, R Sampath-Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental 11beta-hydroxysteroid dehydrogenase type 2 is reduced in pregnancies complicated with idiopathic intrauterine growth Restriction: evidence that this is associated with an attenuated ratio of cortisone to cortisol in the umbilical artery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2007.10.010"}], "href": "https://doi.org/10.1016/j.placenta.2007.10.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18061258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18061258"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gai Liang, Man Chen, Xiao-liang Pan, et al. 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Evaluation of renin-angiotensin-aldosterone system gene polymorphisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/hy1101.099479"}], "href": "https://doi.org/10.1161/hy1101.099479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11711524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11711524"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Barbara Mariniello, Vanessa Ronconi, Cipriana Sardu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20486282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20486282"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rasoul Alikhani-Koupaei, Fatemeh Fouladkou, Pierre Fustier, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2005.09.037"}], "href": "https://doi.org/10.1016/j.neuroscience.2005.09.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16289840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16289840"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Daniel Lavall, Christian Selzer, Pia Schuster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mineralocorticoid receptor promotes fibrotic remodeling in atrial fibrillation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.519256"}], "href": "https://doi.org/10.1074/jbc.M113.519256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24469458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24469458"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Graeme A Deuchar, Danielle McLean, Patrick W F Hadoke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2010-0925"}], "href": "https://doi.org/10.1210/en.2010-0925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21106873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21106873"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Sunaina Seth, Andrew James Lewis, Richard Saffery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal Prenatal Mental Health and Placental 11β-HSD2 Gene Expression: Initial Findings from the Mercy Pregnancy and Emotional Wellbeing Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms161126034"}], "href": "https://doi.org/10.3390/ijms161126034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26593902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26593902"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Elisabeth Conradt, Katheleen Hawes, Dylan Guerin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Child Dev (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cdev.12483"}], "href": "https://doi.org/10.1111/cdev.12483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26822444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26822444"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "A B Makar, K E McMartin, M Palese, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Formate assay in body fluids: application in methanol poisoning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Med (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2944(75)90147-7"}], "href": "https://doi.org/10.1016/0006-2944(75"}, {"type": "t", "text": "90147-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "1"}], "href": "https://pubmed.ncbi.nlm.nih.gov/1"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "K S Bose, R H Sarma "}, {"type": "b", "children": [{"type": "t", "text": "Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90482-9"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90482-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "2"}], "href": "https://pubmed.ncbi.nlm.nih.gov/2"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "R J Smith, R G Bryant "}, {"type": "b", "children": [{"type": "t", "text": "Metal substitutions incarbonic anhydrase: a halide ion probe study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90498-2"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90498-2) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "3"}], "href": "https://pubmed.ncbi.nlm.nih.gov/3"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "U N Wiesmann, S DiDonato, N N Herschkowitz "}, {"type": "b", "children": [{"type": "t", "text": "Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-291x(75)90506-9"}], "href": "https://doi.org/10.1016/0006-291x(75"}, {"type": "t", "text": "90506-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "4"}], "href": "https://pubmed.ncbi.nlm.nih.gov/4"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "T R Anderson, T A Slotkin "}, {"type": "b", "children": [{"type": "t", "text": "Maturation of the adrenal medulla--IV. Effects of morphine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90020-9"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90020-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "R J Lefkowitz "}, {"type": "b", "children": [{"type": "t", "text": "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90001-5"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90001-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "V M Bhagwat, B V Ramachandran "}, {"type": "b", "children": [{"type": "t", "text": "Malathion A and B esterases of mouse liver-I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90011-8"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90011-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "N Akamatsu, H Nakajima, M Ono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increase in acetyl CoA synthetase activity after phenobarbital treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0006-2952(75)90013-1"}], "href": "https://doi.org/10.1016/0006-2952(75"}, {"type": "t", "text": "90013-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "O Isaac, K Thiemer "}, {"type": "b", "children": [{"type": "t", "text": "[Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arzneimittelforschung (1975)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "J Warth, J F Desforges "}, {"type": "b", "children": [{"type": "t", "text": "Determinants of intracellular pH in the erythrocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2141.1975.tb01833.x"}], "href": "https://doi.org/10.1111/j.1365-2141.1975.tb01833.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "N Worathumrong, A J Grimes "}, {"type": "b", "children": [{"type": "t", "text": "The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (1975)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2141.1975.tb00536.x"}], "href": "https://doi.org/10.1111/j.1365-2141.1975.tb00536.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35"}]}]}]}
Synonyms SDR9C3, AME1, AME, HSD11K, HSD2
Proteins DHI2_HUMAN
NCBI Gene ID 3291
API
Download Associations
Predicted Functions View HSD11B2's ARCHS4 Predicted Functions.
Co-expressed Genes View HSD11B2's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View HSD11B2's ARCHS4 Predicted Functions.

Functional Associations

HSD11B2 has 7,430 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for HSD11B2 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by HSD11B2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of HSD11B2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of HSD11B2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of HSD11B2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of HSD11B2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of HSD11B2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with HSD11B2 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with HSD11B2 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSD11B2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of HSD11B2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of HSD11B2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations phenotypes associated with HSD11B2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of HSD11B2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing HSD11B2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing HSD11B2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with HSD11B2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with HSD11B2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of HSD11B2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with HSD11B2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with HSD11B2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with HSD11B2 gene/protein from the curated CTD Gene-Disease Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of HSD11B2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by HSD11B2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with HSD11B2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with HSD11B2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with HSD11B2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with HSD11B2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
DrugBank Drug Targets interacting drugs for HSD11B2 protein from the curated DrugBank Drug Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HSD11B2 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of HSD11B2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of HSD11B2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing HSD11B2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with HSD11B2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with HSD11B2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with HSD11B2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing HSD11B2 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of HSD11B2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving HSD11B2 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving HSD11B2 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving HSD11B2 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing HSD11B2 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing HSD11B2 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing HSD11B2 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by HSD11B2 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by HSD11B2 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by HSD11B2 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of HSD11B2 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of HSD11B2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of HSD11B2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for HSD11B2 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of HSD11B2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of HSD11B2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPO Gene-Disease Associations phenotypes associated with HSD11B2 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for HSD11B2 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuBMAP ASCT+B Annotations cell types associated with HSD11B2 gene from the HuBMAP ASCT+B dataset.
HuBMAP ASCT+B Augmented with RNA-seq Coexpression cell types associated with HSD11B2 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.
HuBMAP Azimuth Cell Type Annotations cell types associated with HSD11B2 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with HSD11B2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for HSD11B2 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of HSD11B2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways pathways involving HSD11B2 protein from the KEGG Pathways dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of HSD11B2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of HSD11B2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with HSD11B2 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of HSD11B2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of HSD11B2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of HSD11B2 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of HSD11B2 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain HSD11B2 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by HSD11B2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of HSD11B2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by HSD11B2 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of HSD11B2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
MW Enzyme Metabolite Associations interacting metabolites for HSD11B2 protein from the MW Gene Metabolite Associations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of HSD11B2 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
OMIM Gene-Disease Associations phenotypes associated with HSD11B2 gene from the curated OMIM Gene-Disease Associations dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for HSD11B2 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of HSD11B2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of HSD11B2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving HSD11B2 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving HSD11B2 protein from the Wikipathways PFOCR 2024 dataset.
Reactome Pathways 2024 pathways involving HSD11B2 protein from the Reactome Pathways 2024 dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of HSD11B2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of HSD11B2 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at HSD11B2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of HSD11B2 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of HSD11B2 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with HSD11B2 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of HSD11B2 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of HSD11B2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of HSD11B2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of HSD11B2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of HSD11B2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of HSD11B2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of HSD11B2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of HSD11B2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with HSD11B2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with HSD11B2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving HSD11B2 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving HSD11B2 protein from the WikiPathways Pathways 2024 dataset.