| Name | histatin 1 |
| Description | This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Histatin‑1 is a highly abundant, histidine‐rich peptide found in human saliva that plays multifaceted roles in tissue repair and homeostasis. Multiple studies have shown that histatin‑1 actively promotes wound closure by stimulating the adhesion, spreading, and migration of epithelial and endothelial cells—processes that are mediated in part by its internalization via pathways such as ERK1/2 (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Post‐translational modifications, including a gland‐specific sulfation on key tyrosine residues, further modulate its bioactivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its cell‐activating properties, histatin‑1 participates in complex protein–protein interactions within saliva. It binds to specific cell‐surface receptors such as the sigma‑2 receptor (TMEM97), which likely underpins its ability to modulate downstream signaling events related to wound healing and angiogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Its presence is not limited to saliva; histatin‑1 has been detected in tears and lacrimal gland tissues, suggesting a potential diagnostic role for ocular surface disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Histatin‑1’s wound‐healing effects have been harnessed experimentally in several tissue types. When used alone or in combination with osteoinductive agents such as BMP‑2, histatin‑1 enhances bone regeneration"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and its topical application in hydrogels or acellular dermal matrices has been shown to accelerate healing of skin burns, corneal abrasions, and other epithelial wounds."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings identify histatin‑1 as a multifunctional salivary peptide that not only contributes to innate antifungal defense but also serves as a potent mediator of cell adhesion, migration, barrier function, and angiogenesis, thereby promoting rapid and effective wound healing across oral, ocular, dermal, and osseous tissues.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Menno J Oudhoff, Jan G M Bolscher, Kamran Nazmi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.08-112003"}], "href": "https://doi.org/10.1096/fj.08-112003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18650243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18650243"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Pedro Torres, Jorge Díaz, Maximiliano Arce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201700085R"}], "href": "https://doi.org/10.1096/fj.201700085R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28751526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28751526"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dandan Ma, Wei Sun, Kamran Nazmi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9040795"}], "href": "https://doi.org/10.3390/cells9040795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32225006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32225006"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Irene A van Dijk, Enno C I Veerman, Eric A J Reits, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2018-0246"}], "href": "https://doi.org/10.1515/hsz-2018-0246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30138105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30138105"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tiziana Cabras, Chiara Fanali, Joana A Monteiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr0700706"}], "href": "https://doi.org/10.1021/pr0700706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17503797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17503797"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Irene A van Dijk, Maria Laura Ferrando, Anne-Eva van der Wijk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201700180R"}], "href": "https://doi.org/10.1096/fj.201700180R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28522595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28522595"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kyung-No Son, Hyun Lee, Dhara Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histatin-1 is an endogenous ligand of the sigma-2 receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.16108"}], "href": "https://doi.org/10.1111/febs.16108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34233061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34233061"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sushma Kalmodia, Kyung-No Son, Dingcai Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-46623-9"}], "href": "https://doi.org/10.1038/s41598-019-46623-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31311993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31311993"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dhara Shah, Marwan Ali, Zeeshan Pasha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histatin-1 Expression in Human Lacrimal Epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0148018"}], "href": "https://doi.org/10.1371/journal.pone.0148018"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26824896"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26824896"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ping Sun, Andi Shi, Chenxi Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human salivary histatin-1 (Hst1) promotes bone morphogenetic protein 2 (BMP2)-induced osteogenesis and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12906"}], "href": "https://doi.org/10.1002/2211-5463.12906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32484586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32484586"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuanyuan Zheng, Weihao Yuan, Huiling Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Injectable supramolecular gelatin hydrogel loading of resveratrol and histatin-1 for burn wound therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomater Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/d0bm00391c"}], "href": "https://doi.org/10.1039/d0bm00391c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32744545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32744545"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Marko Oydanich, Seth P Epstein, Neha Gadaria-Rathod, et al. "}, {"type": "b", "children": [{"type": "t", "text": "In Vivo Efficacy of Histatin-1 in a Rabbit Animal Model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Eye Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/02713683.2018.1490772"}], "href": "https://doi.org/10.1080/02713683.2018.1490772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29945490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29945490"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xiaoxuan Lei, Liuhanghang Cheng, Haiyan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Bioeng Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fbioe.2020.00999"}], "href": "https://doi.org/10.3389/fbioe.2020.00999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32974320"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32974320"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Zhen Lin, Riwang Li, Yi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histatin1-modified thiolated chitosan hydrogels enhance wound healing by accelerating cell adhesion, migration and angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carbohydr Polym (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.carbpol.2019.115710"}], "href": "https://doi.org/10.1016/j.carbpol.2019.115710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31887922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31887922"}]}]}]}
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| Synonyms | HIS1 |
| Proteins | HIS1_HUMAN |
| NCBI Gene ID | 3346 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HTN1 has 1,951 functional associations with biological entities spanning 7 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 71 datasets.
Click the + buttons to view associations for HTN1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of HTN1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of HTN1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HTN1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HTN1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of HTN1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTN1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HTN1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with HTN1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTN1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HTN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HTN1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of HTN1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTN1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HTN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing HTN1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HTN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HTN1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with HTN1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with HTN1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by HTN1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HTN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HTN1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with HTN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with HTN1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTN1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of HTN1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HTN1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with HTN1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HTN1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HTN1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving HTN1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving HTN1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving HTN1 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing HTN1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by HTN1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HTN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HTN1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with HTN1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of HTN1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of HTN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HTN1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving HTN1 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTN1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HTN1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HTN1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of HTN1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing HTN1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain HTN1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of HTN1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of HTN1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for HTN1 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTN1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with HTN1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| Reactome Pathways 2024 | pathways involving HTN1 protein from the Reactome Pathways 2024 dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of HTN1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HTN1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HTN1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of HTN1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HTN1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HTN1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of HTN1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HTN1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of HTN1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HTN1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HTN1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HTN1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
