{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The serotonin 5‐HT_1E receptor (HTR1E) is a G protein–coupled receptor that appears to serve multifaceted roles in both the central nervous system (CNS) and peripheral tissues. In the brain, several genetic studies have implicated HTR1E as a candidate in neuropsychiatric conditions – including attention deficit hyperactivity disorder and autism spectrum disorder – suggesting it may contribute to the modulation of impulsivity, cognition, and behavioral control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In addition, dynamic changes in HTR1E expression in the prefrontal cortex during adolescence have been documented, pointing to a potential role in the maturation of higher‐order brain circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Functional studies further indicate that activation of HTR1E may protect neurons under oxidative stress via interactions with neurotrophic factors and promote antinociceptive effects in inflammatory pain models, as well as exert anticonvulsant activity in epilepsy‐related models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond the CNS, altered expression and methylation of HTR1E have been observed in peripheral tissues. For instance, a specific HTR1E polymorphism has been linked to increased chemosensitivity to paclitaxel in gastric cancer cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", while epigenetic modification of the HTR1E gene in peripheral blood is associated with variations in taste transduction that may influence body mass index and dietary intake."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Additionally, associations of HTR1E with reproductive traits and social genetic effects in livestock point to a broader physiological significance in regulating both developmental and behavioral processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings support a multifaceted function for HTR1E in modulating neurotransmission, neuroprotection, pain processing, and peripheral responses, making it a promising target for further investigations into neurodevelopmental, neuropsychiatric, and systemic disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jessica Lasky-Su, Benjamin M Neale, Barbara Franke, et al. 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