| HGNC Family | 5-hydroxytryptamine (serotonin) receptors (HTR), G protein-coupled receptors |
| Name | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled |
| Description | This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The serotonin 2C receptor (HTR2C) is a multifunctional G‐protein–coupled receptor whose activity is finely tuned at several levels. At the RNA level, its pre–messenger RNA undergoes extensive editing and alternative splicing, processes that are modulated by small nucleolar RNAs and are altered in conditions such as Prader–Willi syndrome and major depression. Such post–transcriptional modifications change the receptor’s pharmacological properties and are thought to contribute to stress responsiveness and mood regulation ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the central nervous system, HTR2C plays a key role in regulating energy balance, appetite, and glucose homeostasis. In particular, its expression in hypothalamic neurons—including pro‐opiomelanocortin (POMC) neurons and neurons of the ventromedial hypothalamus—has been implicated in the regulation of food intake, body weight, and even bone mass accrual via a Ca<sup>2+</sup>/calmodulin kinase cascade that converges on CREB phosphorylation, thereby modulating autonomic output ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic polymorphisms in HTR2C have been associated with psychiatric phenotypes and with the adverse effects of psychotropic medications. In particular, certain promoter and coding variants have been linked to altered risks for major affective disorders as well as to weight gain and movement disorders (eg, tardive dyskinesia) in patients treated with antipsychotic drugs ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the molecular level, HTR2C functions as a homodimer; its structural configuration—including a canonical PDZ ligand motif at the C‐terminus—facilitates specific interactions with intracellular scaffolding proteins and is essential for proper receptor signaling. This dimerization is critical for ligand binding and downstream G–protein activation, and it may also contribute to the receptor’s role in modulating dopaminergic and GABAergic neurotransmission in brain regions such as the ventral tegmental area ["}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": "]. Furthermore, evidence from peripheral tissues suggests that HTR2C may also influence adipocyte differentiation, thereby linking central and peripheral mechanisms in energy homeostasis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight HTR2C as a pivotal regulator of neuroendocrine and metabolic processes whose diverse functions—from RNA editing and receptor dimerization to the modulation of appetite, mood, and dopaminergic transmission—underscore its importance in both normal physiology and in disease states.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shivendra Kishore, Stefan Stamm "}, {"type": "b", "children": [{"type": "t", "text": "The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1118265"}], "href": "https://doi.org/10.1126/science.1118265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16357227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16357227"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ilona Gurevich, Hadassah Tamir, Victoria Arango, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(02)00660-8"}], "href": "https://doi.org/10.1016/s0896-6273(02"}, {"type": "t", "text": "00660-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11988167"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11988167"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ilona Gurevich, Michael T Englander, Mella Adlersberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of serotonin 2C receptor editing by sustained changes in serotonergic neurotransmission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12486144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12486144"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael T Englander, Stephanie C Dulawa, Punita Bhansali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3895-04.2005"}], "href": "https://doi.org/10.1523/JNEUROSCI.3895-04.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15659601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15659601"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Christine M Doe, Dinko Relkovic, Alastair S Garfield, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp137"}], "href": "https://doi.org/10.1093/hmg/ddp137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19304781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19304781"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vijay K Yadav, Franck Oury, Nina Suda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2009.06.051"}], "href": "https://doi.org/10.1016/j.cell.2009.06.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19737523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19737523"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Gavin P Reynolds, Zhi-Jun Zhang, Xiao-Bin Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lancet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/S0140-6736(02)08913-4"}], "href": "https://doi.org/10.1016/S0140-6736(02"}, {"type": "t", "text": "08913-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12086765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12086765"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lucy A Templeman, Gavin P Reynolds, Belen Arranz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/01213011-200504000-00002"}], "href": "https://doi.org/10.1097/01213011-200504000-00002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15864111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15864111"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Eric D Berglund, Chen Liu, Jong-Woo Sohn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI70338"}], "href": "https://doi.org/10.1172/JCI70338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24177424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24177424"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Caleb C Lord, Steven C Wyler, Rong Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI93362"}], "href": "https://doi.org/10.1172/JCI93362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28805659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28805659"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Franck Oury, Vijay K Yadav, Ying Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1977210"}], "href": "https://doi.org/10.1101/gad.1977210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20952540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20952540"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "B Lerer, F Macciardi, R H Segman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.mp.4000883"}], "href": "https://doi.org/10.1038/sj.mp.4000883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11526472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11526472"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "R H Segman, U Heresco-Levy, B Finkel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the serotonin 2C receptor gene and tardive dyskinesia in chronic schizophrenia: additive contribution of 5-HT2Cser and DRD3gly alleles to susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychopharmacology (Berl) (2000)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s002130000521"}], "href": "https://doi.org/10.1007/s002130000521"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11140333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11140333"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Gavin P Reynolds, Lucy A Templeman, Zhi Jun Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prog Neuropsychopharmacol Biol Psychiatry (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pnpbp.2005.03.019"}], "href": "https://doi.org/10.1016/j.pnpbp.2005.03.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15953671"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15953671"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gavin P Reynolds, Zhijian Yao, XiaoBin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Neuropsychopharmacol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.euroneuro.2004.07.001"}], "href": "https://doi.org/10.1016/j.euroneuro.2004.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15695058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15695058"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Carine Bécamel, Sophie Gavarini, Benjamin Chanrion, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312106200"}], "href": "https://doi.org/10.1074/jbc.M312106200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14988405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14988405"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Katharine Herrick-Davis, Ellinor Grinde, Timothy J Harrigan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M507396200"}], "href": "https://doi.org/10.1074/jbc.M507396200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195233"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "M J Bubar, K A Cunningham "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of serotonin 5-HT2C receptors in the ventral tegmental area."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2006.12.071"}], "href": "https://doi.org/10.1016/j.neuroscience.2006.12.071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17367945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17367945"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Minako Kinoshita, Koh Ono, Takahiro Horie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of adipocyte differentiation by activation of serotonin (5-HT) receptors 5-HT2AR and 5-HT2CR and involvement of microRNA-448-mediated repression of KLF5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2010-0054"}], "href": "https://doi.org/10.1210/me.2010-0054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20719859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20719859"}]}]}]}
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| Synonyms | 5-HTR2C, 5HTR2C, 5-HT1C, HTR1C, 5-HT2C |
| Proteins | 5HT2C_HUMAN |
| NCBI Gene ID | 3358 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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HTR2C has 5,567 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.
Click the + buttons to view associations for HTR2C from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by HTR2C gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR2C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR2C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of HTR2C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of HTR2C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of HTR2C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| Biocarta Pathways | pathways involving HTR2C protein from the Biocarta Pathways dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR2C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HTR2C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of HTR2C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR2C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR2C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with HTR2C gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTR2C gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of HTR2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of HTR2C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTR2C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing HTR2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing HTR2C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with HTR2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with HTR2C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR2C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with HTR2C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with HTR2C gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with HTR2C gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with HTR2C gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by HTR2C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with HTR2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with HTR2C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with HTR2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with HTR2C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| DrugBank Drug Targets | interacting drugs for HTR2C protein from the curated DrugBank Drug Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HTR2C gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of HTR2C gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of HTR2C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing HTR2C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with HTR2C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with HTR2C gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR2C gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with HTR2C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing HTR2C from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of HTR2C gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving HTR2C gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving HTR2C gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving HTR2C gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing HTR2C protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing HTR2C protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing HTR2C protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by HTR2C gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by HTR2C gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by HTR2C gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of HTR2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of HTR2C gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding HTR2C receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with HTR2C gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with HTR2C gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of HTR2C gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for HTR2C protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of HTR2C protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for HTR2C from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuBMAP ASCT+B Annotations | cell types associated with HTR2C gene from the HuBMAP ASCT+B dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with HTR2C gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with HTR2C gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with HTR2C gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for HTR2C protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of HTR2C gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEA Substrates of Kinases | kinases that phosphorylate HTR2C protein from the curated KEA Substrates of Kinases dataset. | |
| KEGG Pathways | pathways involving HTR2C protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of HTR2C gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with HTR2C gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of HTR2C gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of HTR2C gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain HTR2C protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by HTR2C gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting HTR2C gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of HTR2C gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by HTR2C gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for HTR2C from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of HTR2C gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of HTR2C gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PANTHER Pathways | pathways involving HTR2C protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for HTR2C from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of HTR2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of HTR2C gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving HTR2C protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving HTR2C protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with HTR2C protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| Reactome Pathways 2014 | pathways involving HTR2C protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving HTR2C protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at HTR2C gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of HTR2C gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of HTR2C gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of HTR2C gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of HTR2C gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of HTR2C gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of HTR2C gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of HTR2C protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of HTR2C protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with HTR2C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with HTR2C protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving HTR2C protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving HTR2C protein from the WikiPathways Pathways 2024 dataset. | |
