{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Serotonin receptor 7 (HTR7) is a versatile G protein–coupled receptor that signals predominantly via G_s‐mediated activation of adenylyl cyclase and exhibits intrinsic constitutive activity, which is modulated by post‐translational modifications such as palmitoylation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]. In peripheral tissues, HTR7 is widely expressed; for example, it is found in human skin cells where it contributes to the regulation of cell proliferation and viability, suggesting a role in maintaining cutaneous homeostasis ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "]. Moreover, HTR7 plays a key role in the regulation of immune responses: in macrophages, it mediates the inhibitory effects of serotonin on proinflammatory cytokine release and promotes anti‐inflammatory (M2) polarization, making it a promising target in inflammatory conditions ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Within the central nervous system, HTR7 interacts with other serotonin receptors—for instance, by forming heterodimers with 5‑HT_1A receptors—to fine‐tune neuronal signaling, affecting potassium channel activation and mitogen‐activated protein kinase cascades; such interactions have been implicated in mood regulation and schizophrenia ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "]. Activation of HTR7 in the hippocampus is essential for proper spatial memory consolidation and synaptic plasticity, as HTR7‐deficient mice exhibit impaired allocentric memory ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, HTR7 is critical for motor function; in the spinal cord it contributes to the generation and coordination of locomotor rhythm, with receptor knockout models displaying disrupted and uncoordinated motor activity ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "]. HTR7 activation is also a key mediator of sensory responses, particularly in triggering both acute and chronic itch through downstream activation of TRPA1 ion channels ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "].\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Pharmacological studies further reveal that certain drugs, such as risperidone, can induce long‐lasting inactivation of HTR7—an effect potentially mediated by the receptor’s unique structural features—underscoring its attractiveness as a therapeutic target ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "]. Collectively, these observations highlight the multifaceted role of HTR7 in regulating immune function, neuronal signaling, sensory processing, and motor coordination, thereby offering promising avenues for intervention in a broad spectrum of pathophysiological conditions ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "].\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kurt A Krobert, Finn Olav Levy "}, {"type": "b", "children": [{"type": "t", "text": "The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.bjp.0704588"}], "href": "https://doi.org/10.1038/sj.bjp.0704588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11906971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11906971"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elena Kvachnina, Aline Dumuis, Jakub Wlodarczyk, et al. 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