IFI30 Gene

Name	interferon, gamma-inducible protein 30
Description	The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n IFI30, also known as gamma‐interferon–inducible lysosomal thiol reductase (GILT), is a multifunctional enzyme that plays a central role in antigen processing and immune regulation. By catalyzing the reduction of disulfide bonds in endocytosed proteins within acidic lysosomal compartments, IFI30 promotes antigen unfolding and proteolytic degradation—a critical step for optimal peptide loading onto major histocompatibility complex (MHC) class II molecules (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " This activity is essential not only for the presentation of conventional disulfide‐rich antigens such as hen egg lysozyme and melanocyte differentiation proteins but also for the efficient cross‐presentation of viral antigens to CD8+ T cells (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " In addition, IFI30 influences broader immune outcomes by modulating the redox environment within endolysosomal compartments, which can impact phagosomal proteolytic efficiency and tune T‐cell receptor sensitivity as well as central tolerance (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, by reducing disulfide bonds on microbial toxins such as listeriolysin O, IFI30 facilitates pathogen escape from the phagosome, thereby contributing to Listeria monocytogenes infection (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " Altogether, IFI30 functions as a critical integrator at the crossroads of antigen processing, adaptive immunity, and redox regulation—with implications for tumor immunogenicity, autoimmunity, and host–pathogen interactions (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M Maric, B Arunachalam, U T Phan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective antigen processing in GILT-free mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1065500"}], "href": "https://doi.org/10.1126/science.1065500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11701933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11701933"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "K Taraszka Hastings, Rebecca L Lackman, Peter Cresswell "}, {"type": "b", "children": [{"type": "t", "text": "Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.177.12.8569"}], "href": "https://doi.org/10.4049/jimmunol.177.12.8569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17142755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17142755"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Uyen T Phan, Rebecca L Lackman, Peter Cresswell "}, {"type": "b", "children": [{"type": "t", "text": "Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.182430499"}], "href": "https://doi.org/10.1073/pnas.182430499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12198183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12198183"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Reshma Singh, Peter Cresswell "}, {"type": "b", "children": [{"type": "t", "text": "Defective cross-presentation of viral antigens in GILT-free mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1189176"}], "href": "https://doi.org/10.1126/science.1189176"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20538950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20538950"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "M Azizul Haque, Ping Li, Sheila K Jackson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20011853"}], "href": "https://doi.org/10.1084/jem.20011853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12021307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12021307"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Oliver G Goldstein, Laela M Hajiaghamohseni, Shereen Amria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immunol Immunother (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00262-008-0483-8"}], "href": "https://doi.org/10.1007/s00262-008-0483-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18343923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18343923"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laura Ciaccia West, Peter Cresswell "}, {"type": "b", "children": [{"type": "t", "text": "Expanding roles for GILT in immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Opin Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.coi.2012.11.006"}], "href": "https://doi.org/10.1016/j.coi.2012.11.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23246037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23246037"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Maja Maric, Igor Barjaktarevic, Branka Bogunovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: developmental up-regulation of IFN-gamma-inducible lysosomal thiol reductase expression leads to reduced T cell sensitivity and less severe autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.182.2.746"}], "href": "https://doi.org/10.4049/jimmunol.182.2.746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19124716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19124716"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hao-Sen Chiang, Maja Maric "}, {"type": "b", "children": [{"type": "t", "text": "Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2011.05.015"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2011.05.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21640818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21640818"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Reshma Singh, Amanda Jamieson, Peter Cresswell "}, {"type": "b", "children": [{"type": "t", "text": "GILT is a critical host factor for Listeria monocytogenes infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07344"}], "href": "https://doi.org/10.1038/nature07344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18815593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18815593"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Matthew P Rausch, Karen Taraszka Hastings "}, {"type": "b", "children": [{"type": "t", "text": "Diverse cellular and organismal functions of the lysosomal thiol reductase GILT."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2015.06.008"}], "href": "https://doi.org/10.1016/j.molimm.2015.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26116226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26116226"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Matthew P Rausch, K Taraszka Hastings "}, {"type": "b", "children": [{"type": "t", "text": "GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2011.236"}], "href": "https://doi.org/10.1038/jid.2011.236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21833020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21833020"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yan Su, Gregory Carey, Maja Maric, et al. "}, {"type": "b", "children": [{"type": "t", "text": "B cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-gamma-inducible lysosomal thiol reductase-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.2.1153"}], "href": "https://doi.org/10.4049/jimmunol.181.2.1153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18606668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18606668"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dale R Balce, Euan R O Allan, Neil McKenna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.584391"}], "href": "https://doi.org/10.1074/jbc.M114.584391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25253686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25253686"}]}]}]}
Synonyms	IFI-30, IP-30, IP30, GILT
Proteins	GILT_HUMAN
NCBI Gene ID	10437
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IFI30 has 7,061 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 113 datasets.

Click the + buttons to view associations for IFI30 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IFI30 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by IFI30 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IFI30 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IFI30 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IFI30 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IFI30 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IFI30 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IFI30 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IFI30 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IFI30 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IFI30 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IFI30 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IFI30 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IFI30 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IFI30 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IFI30 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IFI30 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IFI30 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IFI30 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IFI30 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IFI30 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IFI30 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing IFI30 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IFI30 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IFI30 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IFI30 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IFI30 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IFI30 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IFI30 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IFI30 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IFI30 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IFI30 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IFI30 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IFI30 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IFI30 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IFI30 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IFI30 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IFI30 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of IFI30 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing IFI30 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IFI30 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.