IGF2BP2 Gene

HGNC Family	RNA binding motif containing (RBM)
Name	insulin-like growth factor 2 mRNA binding protein 2
Description	This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2), also known as IMP2, functions as an RNA‐binding regulator that modulates the stability and translation of its target mRNAs. Large‐scale genome‐wide association studies have repeatedly identified intronic variants in IGF2BP2 as being associated with an increased risk for type 2 diabetes, although the precise mechanisms—beyond subtle effects on beta‐cell function—remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its established link to type 2 diabetes, IGF2BP2 plays a critical role in cellular metabolism and cancer biology. In glioblastoma stem‐like cells, for example, IGF2BP2 binds to a suite of mRNAs encoding mitochondrial respiratory chain subunits and directly interacts with protein components of complex I, thereby sustaining oxidative phosphorylation and promoting clonogenic growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic cancer, IGF2BP2 acts as a reader of N6‐methyladenosine modifications by binding to and stabilizing the long noncoding RNA DANCR. This stabilization enhances cell proliferation and stemness‐like properties, pointing to a mechanistic role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In metabolic regulation, studies in mice have shown that loss of IGF2BP2 (IMP2) leads to increased translational efficiency of key mRNAs—such as that encoding UCP1—resulting in higher energy expenditure, resistance to diet‐induced obesity, and improved insulin sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additionally, in colorectal cancer, the long noncoding RNA LINRIS promotes tumor progression by stabilizing IGF2BP2 protein levels; knockdown of LINRIS decreases IGF2BP2 and impairs cancer cell growth, further underscoring the importance of IGF2BP2 in oncogenic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, IGF2BP2 serves as a multifaceted regulator that contributes to type 2 diabetes susceptibility and influences cancer cell bioenergetics and stemness by controlling the fate of mRNAs involved in mitochondrial function, cellular growth, and metabolism.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Richa Saxena, Benjamin F Voight, Valeriya Lyssenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1142358"}], "href": "https://doi.org/10.1126/science.1142358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17463246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17463246"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laura J Scott, Karen L Mohlke, Lori L Bonnycastle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1142382"}], "href": "https://doi.org/10.1126/science.1142382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17463248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17463248"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eleftheria Zeggini, Michael N Weedon, Cecilia M Lindgren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1142364"}], "href": "https://doi.org/10.1126/science.1142364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17463249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17463249"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Valeriya Lyssenko, Anna Jonsson, Peter Almgren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical risk factors, DNA variants, and the development of type 2 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa0801869"}], "href": "https://doi.org/10.1056/NEJMoa0801869"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19020324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19020324"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michalina Janiszewska, Mario L Suvà, Nicolo Riggi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.188292.112"}], "href": "https://doi.org/10.1101/gad.188292.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22899010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22899010"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoge Hu, Wan-Xin Peng, Huaixiang Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41418-019-0461-z"}], "href": "https://doi.org/10.1038/s41418-019-0461-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31804607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31804607"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ning Dai, Liping Zhao, Diedra Wrighting, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2015.03.006"}], "href": "https://doi.org/10.1016/j.cmet.2015.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25863250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25863250"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yun Wang, Jia-Huan Lu, Qi-Nian Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1105-0"}], "href": "https://doi.org/10.1186/s12943-019-1105-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31791342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31791342"}]}]}]}
Synonyms	IMP-2, IMP2, VICKZ2
Proteins	IF2B2_HUMAN
NCBI Gene ID	10644
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGF2BP2 has 13,742 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 132 datasets.

Click the + buttons to view associations for IGF2BP2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGF2BP2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGF2BP2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGF2BP2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of IGF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of IGF2BP2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of IGF2BP2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of IGF2BP2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGF2BP2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGF2BP2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of IGF2BP2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of IGF2BP2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of IGF2BP2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with IGF2BP2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IGF2BP2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGF2BP2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IGF2BP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of IGF2BP2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGF2BP2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGF2BP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing IGF2BP2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing IGF2BP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing IGF2BP2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with IGF2BP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with IGF2BP2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of IGF2BP2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with IGF2BP2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with IGF2BP2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with IGF2BP2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with IGF2BP2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of IGF2BP2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by IGF2BP2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving IGF2BP2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with IGF2BP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with IGF2BP2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGF2BP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with IGF2BP2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with IGF2BP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with IGF2BP2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at IGF2BP2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGF2BP2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.