IGHG3 Gene

HGNC Family	Immunoglobulins (IG)
Name	immunoglobulin heavy constant gamma 3 (G3m marker)
Description	Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Mar 2025]
Synonyms	IGG3
Proteins	IGHG3_HUMAN
NCBI Gene ID	3502
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

IGHG3 has 895 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 27 datasets.

Click the + buttons to view associations for IGHG3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

IGHG3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of IGHG3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with IGHG3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of IGHG3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of IGHG3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing IGHG3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with IGHG3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	GAD Gene-Disease Associations	diseases associated with IGHG3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with IGHG3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with IGHG3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing IGHG3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of IGHG3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of IGHG3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of IGHG3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GlyGen Glycosylated Proteins	ligands (chemical) binding IGHG3 protein from the GlyGen Glycosylated Proteins dataset.
	GO Biological Process Annotations 2023	biological processes involving IGHG3 gene from the curated GO Biological Process Annotations 2023 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of IGHG3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of IGHG3 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GTEx Tissue-Specific Aging Signatures	tissue samples with high or low expression of IGHG3 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
	Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles	cell lines with high or low expression of IGHG3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
	Hub Proteins Protein-Protein Interactions	interacting hub proteins for IGHG3 from the curated Hub Proteins Protein-Protein Interactions dataset.
	HuBMAP Azimuth Cell Type Annotations	cell types associated with IGHG3 gene from the HuBMAP Azimuth Cell Type Annotations dataset.
	HuGE Navigator Gene-Phenotype Associations	phenotypes associated with IGHG3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
	Pathway Commons Protein-Protein Interactions	interacting proteins for IGHG3 from the Pathway Commons Protein-Protein Interactions dataset.
	Reactome Pathways 2014	pathways involving IGHG3 protein from the Reactome Pathways dataset.
	Sanger Dependency Map Cancer Cell Line Proteomics	cell lines associated with IGHG3 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of IGHG3 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores	tissues co-occuring with IGHG3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.